4 terminated, 2 completed. 4 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 2, Terminated 2 |
| Phase 2 | 2 | Terminated 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES BIIB092, Placebo - Primary Tauopathies, Corticobasal Degeneration Syndrome | Phase 1 | Terminated | University of California, San Francisco | 22 | 2018-09-12 | 2019-12-19 |
| Phase 2 Study of BIIB092 in Participants With Early Alzheimer's Disease BIIB092, Placebo - Alzheimer's Disease | Phase 2 | Terminated | Biogen | 654 | 2018-05-03 | 2022-11-08 |
| Study of BIIB092 in Participants With Progressive Supranuclear Palsy BIIB092, Placebo - Supranuclear Palsy, Progressive | Phase 2 | Terminated | Biogen | 490 | 2017-06-01 | 2020-12-21 |
| Extension Study of BIIB092 in Participants With Progressive Supranuclear Palsy (PSP) Who Participated in CN002003 BIIB092 - Supranuclear Palsy, Progressive | Phase 1 | Terminated | Biogen | 47 | 2016-02-22 | 2020-05-18 |
| Multiple Ascending Dose Study of Intravenously Administered BMS-986168 (BIIB092) in Patients With Progressive Supranuclear Palsy BIIB092, Placebo - Progressive Supranuclear Palsy | Phase 1 | Completed | Biogen | 48 | 2015-10-02 | 2018-09-04 |
| A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study of Intravenously Administered BMS-986168 in Healthy Subjects BMS-986168, BMS-986168 Placebo - Tauopathies | Phase 1 | Completed | Biogen | 65 | 2014-12-31 | 2017-11-06 |
Supranuclear Palsy, Progressive (3) · Alzheimer Disease (1) · Cognitive Dysfunction (1) · Color Vision Defects (1) · Pick Disease of the Brain (1) · Primary Progressive Nonfluent Aphasia (1) · Tauopathies (1)
Biogen (5) · University of California, San Francisco (1)
United States (6) · Australia (2) · France (2) · Germany (2) · Italy (2) · Japan (2) · Spain (2) · Austria (1) · Canada (1) · Greece (1) · Poland (1) · Russia (1) · South Korea (1) · Sweden (1) · United Kingdom (1)
PMID 31122495, PMID 34385707, PMID 34736158, PMID 38012285, PMID 38825840
2016 (1), 2017 (1)