14 completed, 2 withdrawn, 1 not yet recruiting, 1 unknown. 7 Phase 1, 5 Phase 2, 3 Not applicable, 3 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 7 |
| Phase 2 | 5 | Completed 4, Withdrawn 1 |
| Not applicable | 3 | Completed 2, Unknown 1 |
| Phase 3 | 3 | Withdrawn 2, Not yet recruiting 1 |
| Early Phase 1 | 1 | Completed 1 |
Follow tricaprylin: new trials by email Literature Review of tricaprylin trials Research Report on tricaprylin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tricaprilin Phase 3 ALTER-AD (Alternative-Alzheimer Disease) Study Tricaprilin, Placebo - Alzheimer Disease | Phase 3 | Not yet recruiting | Cerecin | 535 | 2026-12-01 | 2026-07-01 |
| A Phase III Multi Regional Clinical Trial (MRCT) of Tricaprilin in Mild to Moderately Severe Probable Alzheimer's Disease With Optional Open Label Extension Tricaprilin, Placebo - Alzheimer's Disease | Phase 3 | Withdrawn | Cerecin | 2022-06-30 | 2023-04-14 | |
| Tricaprilin Infantile Spasms Pilot Study Tricaprilin - Infantile Spasm | Phase 1 | Completed | Cerecin | 8 | 2021-11-01 | 2024-09-19 |
| Tricaprilin Phase 2 Pilot Study in Migraine Tricaprilin, Placebo - Migraine | Phase 2 | Completed | Cerecin | 83 | 2020-12-17 | 2024-02-08 |
| Study to Compare the Pharmacokinetics of Daily Administration of Tricaprilin on Ketone Body Production Tricaprilin - Alzheimer Disease | Phase 1 | Completed | Cerecin | 12 | 2020-02-27 | 2020-07-08 |
| Study to Compare the Pharmacokinetics of Tricaprilin Formulations and a Placebo on Ketone Body Production Tricaprilin, Placebo - Alzheimer Disease | Phase 1 | Completed | Cerecin | 32 | 2019-08-30 | 2020-07-08 |
| Taste-masking Study for Tricaprilin in Sensory Panelists Tricaprilin - Taste Profile Assessments | Phase 1 | Completed | Cerecin | 9 | 2018-09-10 | 2019-11-06 |
| The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses Triheptanoin, Placebo Oil - Tarui Disease, Debrancher Deficiency | Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 3 | 2018-08-15 | 2024-02-22 |
| Pharmacokinetics of Tricaprilin Including Food Effect on Ketone Body Production tricaprilin, standard meal, high-fat meal - Alzheimer Disease | Phase 1 | Completed | Cerecin | 20 | 2018-08-05 | 2019-05-29 |
| Fat Metabolites and Gut Hormones C-8 dietary oil, Tricaprylin, Olive oil - Overweight and Obesity, Type 2 Diabetes | Not applicable | Unknown | Hvidovre University Hospital | 20 | 2017-08-07 | 2017-07-26 |
| Evaluation of PK of Caprylic Triglyceride Oil, AC-1202, AC-1204, and Axona on Ketone Body Production Caprylic Triglyceride Oil, AC-1202, Axona - Healthy | Phase 1 | Completed | Cerecin | 20 | 2016-07-01 | 2017-04-11 |
| Evaluation of PK of AC1204 v Caprylic Triglyceride Oil Incl Food Effect on Ketone Body Production AC-1204, caprylic triglyceride oil (standard breakfast), caprylic triglyceride oil (high fat breakfast) - Healthy | Phase 1 | Completed | Cerecin | 16 | 2016-04-01 | 2016-10-28 |
| 13C Trioctanoate Breath Test as a Measurement of Gastric Fat Volume Emptying Octanoic acid (1-13C, 99%), TRIOCTANOIN (1,1,1-13C3, 99%) - Healthy | Early Phase 1 | Completed | University of Zurich | 32 | 2015-10-01 | 2016-07-22 |
| Comparing the Ketogenic Effect of Coconut Oil and Different MCTs Coconut oil, Coconut oil + MCT, MCT - Healthy Adults | Not applicable | Completed | Université de Sherbrooke | 10 | 2015-06-01 | 2020-04-06 |
| Caprylic Triglyceride for Treatment of Cognitive Impairments in Multiple Sclerosis Caprylic Triglyceride, Placebo - Relapsing Remitting MS, Secondary Progressive MS | Not applicable | Completed | University of Miami | 124 | 2013-02-01 | 2018-01-25 |
| Tricaprilin In Age-Associated Memory Impairment Tricaprilin, Placebo - Age-Associated Memory Impairment | Phase 2 | Completed | Cerecin | 156 | 2006-07-01 | 2020-09-18 |
| Tricaprilin in Mild to Moderate Alzheimer's Disease Tricaprilin, Placebo - Alzheimer's Disease | Phase 2 | Completed | Cerecin | 152 | 2004-11-04 | 2020-09-21 |
| AC-1204 Long-term Efficacy Response Trial (ALERT Protocol) caprylic triglyceride, long-chain triglyceride - Alzheimer's Disease | Phase 2 / Phase 3 | Withdrawn | Cerecin | 2012-12-04 |
Alzheimer Disease (7) · Ketosis (3) · Cognition Disorders (1) · Cognitive Dysfunction (1) · Diabetes Mellitus, Type 2 (1) · Glycogen Storage Disease Type III (1) · Glycogen Storage Disease Type VII (1) · Migraine Disorders (1) · Multiple Sclerosis (1) · Obesity (1) · Overweight (1) · Spasms, Infantile (1)
Cerecin (13) · Copenhagen University Hospital, Rigshospitalet (1) · Hvidovre University Hospital (1) · University of Miami (1) · University of Zurich (1) · Université de Sherbrooke (1)
United States (8) · Australia (4) · Denmark (2) · Canada (1) · Singapore (1) · Switzerland (1)
Carol McKenna (1) · Colleen Hunsaker, D.O. (1) · Geri Poss, MD (1) · Leticia Tornes, M.D. (1) · Mildred Farmer, MD (1) · Samuel Henderson, PhD (1) · Stephen Cunnane, PhD (1) · Thomas Hochadel, Pharm.D. (1)
PMID 12122118, PMID 12210323, PMID 1281472, PMID 15293280, PMID 15781190, PMID 1580445, PMID 16602102, PMID 16763895, PMID 16763896, PMID 17584774, PMID 1824792, PMID 18401027, PMID 18541798, PMID 18645163, PMID 18929906, PMID 19237700, PMID 19664276, PMID 20357282, PMID 20393176, PMID 20631546, PMID 20655781, PMID 21992747, PMID 2199596, PMID 2295969, PMID 23031366, PMID 23507172, PMID 24453079, PMID 25272951, PMID 25832663, PMID 26255073, PMID 26652229, PMID 27605407, PMID 28566523, PMID 28932990, PMID 31742316, PMID 3447177, PMID 39094432, PMID 5235982, PMID 7634753, PMID 8755644
2017 (1)