4 completed, 2 terminated, 2 unknown, 1 active not recruiting. 10 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 4, Terminated 2, Unknown 2, Active not recruiting 1, Not yet recruiting 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Intraventricular Hemorrhage: new trials by email Literature Review of Intraventricular Hemorrhage trials Research Report on Intraventricular Hemorrhage
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Single-dose Prophylactic INdomethacin in Extremely Preterm Infants Indomethacin, Placebo - Extreme Prematurity, Intraventricular Hemorrhage | Phase 2 | Not yet recruiting | University of British Columbia | 500 | 2025-11-01 | 2025-09-03 |
| A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature Infants OHB-607 - Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity | Phase 2 | Active not recruiting | OHB Neonatology Ltd. | 295 | 2019-05-09 | 2026-08-03 |
| Antibiotic "Dysbiosis" in Preterm Infants Antibiotic, Gastric fluid, Breast milk - Enterocolitis, Necrotizing, Bacteremia | Phase 2 | Completed | University of Florida | 98 | 2017-01-16 | 2024-06-05 |
| Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Indomethacin, delay in umbilical cord clamp at birth, placebo infusion - Intraventricular Hemorrhage, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Hong Huang | 256 | 2014-08-01 | 2021-11-23 |
| Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage Tissue Plasminogen Activator, Placebo - Aneurysmal Subarachnoid Hemorrhage, Intraventricular Hemorrhage | Phase 2 | Unknown | University of Calgary | 12 | 2009-10-01 | 2010-11-11 |
| Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants recombinant human erythropoietin (rhEpo), Normal saline - Infant, Premature, Leukomalacia, Periventricular | Phase 1 / Phase 2 | Unknown | China Medical University Hospital | 100 | 2009-08-01 | 2009-05-29 |
| Inhaled Nitric Oxide and Neuroprotection in Premature Infants inhaled nitric oxide, oxygen - Prematurity, Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Terminated | University of Chicago | 273 | 2008-05-01 | 2024-10-17 |
| Protective Effects of Delayed Cord Clamping in Very Low Birth Weight (VLBW) Infants delayed umbilical cord clamping, Immediate cord clamping - Intraventricular Hemorrhage, Sepsis | Phase 2 | Completed | University of Rhode Island | 211 | 2008-02-01 | 2015-05-27 |
| High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Erythropoietin, Saline placebo - Infant, Premature, Erythropoietin | Phase 2 | Terminated | Atlantic Health System | 22 | 2007-07-01 | 2013-07-30 |
| Clinical Trial on Treatment of Intraventricular Hemorrhage tissue plasminogen activator, rt-PA (thrombolytic) (Cathflo) - Intraventricular Hemorrhage | Phase 2 | Completed | Johns Hopkins University | 52 | 2004-02-01 | 2017-12-11 |
Leukomalacia, Periventricular (5) · Bronchopulmonary Dysplasia (3) · Premature Birth (3) · Brain Injuries (2) · Retinopathy of Prematurity (2) · Bacteremia (1) · Enterocolitis, Necrotizing (1) · Sepsis (1) · Subarachnoid Hemorrhage (1)
Brain Diseases (6) · Cardiovascular Diseases (6) · Central Nervous System Diseases (6) · Cerebrovascular Disorders (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Infant, Newborn, Diseases (6) · Infant, Premature, Diseases (6) · Nervous System Diseases (6) · Vascular Diseases (6) · Encephalomalacia (5) · Female Urogenital Diseases and Pregnancy Complications (3) · Lung Diseases (3) · Lung Injury (3) · Obstetric Labor Complications (3) · Obstetric Labor, Premature (3)
Indomethacin (2) · Saline Solution (2) · Tissue Plasminogen Activator (2) · Ampicillin (1) · Anti-Bacterial Agents (1) · Cefotaxime (1) · Erythropoietin (1) · Fibrinolytic Agents (1) · Gentamicins (1) · Insulin-Like Growth Factor I (1) · Milk, Human (1) · Oxygen (1) · Umbilical Cord Clamping (1)
Atlantic Health System (1) · China Medical University Hospital (1) · Hong Huang (1) · Johns Hopkins University (1) · OHB Neonatology Ltd. (1) · University of British Columbia (1) · University of Calgary (1) · University of Chicago (1) · University of Florida (1) · University of Rhode Island (1)
United States (8) · Canada (4) · Australia (2) · Germany (2) · United Kingdom (2) · Finland (1) · Ireland (1) · Italy (1) · Japan (1) · Netherlands (1) · Portugal (1) · Spain (1) · Sweden (1) · Taiwan (1)
Andreas Kramer, MD (1) · Bai-Horng Su, MD, PhD (1) · Daniel F Hanley, MD (1) · Hong Huang, MD-PhD (1) · John Bauer, PhD (1) · Josef Neu, MD (1) · Judith S Mercer, PhD, CNM (1) · Michael D. Schreiber, M.D. (1) · Souvik Mitra, MD, PhD (1) · Vicki Whitehead, RN (1)
PMID 21940973, PMID 22331336, PMID 22382155, PMID 22474059, PMID 23370203, PMID 23463422, PMID 26228884, PMID 26547399, PMID 29954605, PMID 33479274, PMID 35681088, PMID 37308133, PMID 39373498, PMID 41786363
2018 (1), R01HD070792 (1), R01NR010015 (1), R21HD088005 (1)