131 completed, 52 recruiting, 38 unknown, 26 terminated. 79 Phase 2, 68 Phase 1, 58 Not applicable, 25 Phase 3, 2 Phase 4.
Follow Anus Neoplasms: new trials by email Literature Review of Anus Neoplasms trials Research Report on Anus Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Clinic Delivery of HIV-related Anal Health Services PEACHES 2.0 Implementation Strategies - HIV, Gonorrhea | Not applicable | Not yet recruiting | Albert Einstein College of Medicine | 8 | 2028-02-01 | 2026-10-13 |
| COQ10 and Vitamin E for Off-Target Radiation Toxicity Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab - Prostate Cancer, Uterine Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 200 | 2026-12-01 | 2026-10-08 |
| Swabs in Screening for HPV (SWISH) Self-collected anal swab - Anal Cancer, Human Papilloma Virus (HPV) | Not applicable | Not yet recruiting | Kirby Institute | 700 | 2026-11-01 | 2026-08-27 |
| Epidemiology of Anal Human Papillomavirus Carriage in Female Solid Organ Transplant Recipients With More Than 10 Years of Immunosuppression Anal Self-Sampling for High-Risk HPV Detection - Human Papillomavirus Infection, Anal HPV Infection | Not applicable | Not yet recruiting | University Hospital, Montpellier | 190 | 2026-10-01 | 2026-10-05 |
| Mind-Body Sexual Well-Being Program for Female GI Cancer Survivors Mind-Body Group Intervention, Enhanced Usual Care Control (EUCC) - Colorectal Cancer (Diagnosis), Anal Cancer | Not applicable | Not yet recruiting | Massachusetts General Hospital | 100 | 2026-10-01 | 2026-09-08 |
| Phase 2 Study of Pembrolizumab and Lenvatinib in Anal Squamous Cell Cancer Lenvatinib, Pembrolizumab - Anal Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 17 | 2026-09-30 | 2026-07-02 |
| Blood Biomarkers Based Screening for HPV-driven OPC HPV16-E6 serology and HPV ctDNA - Head and Neck Squamous Cell Carcinoma, Anal Cancer | Not applicable | Not yet recruiting | UNICANCER | 10000 | 2026-09-01 | 2026-05-26 |
| Shortening Radiation Course Duration Using Simultaneous Integrated Boost With Lower Intensity Elective Nodal Dosing and Concurrent Chemotherapy for High-Risk Anal Squamous Cell Carcinoma Hypofractionated Radiation Therapy - Anal Cancer | Phase 2 | Enrolling by invitation | University of Vermont Medical Center | 24 | 2026-08-26 | 2026-09-15 |
| A Study of IDP-001 in Advanced or Metastatic Solid Tumors IDP-001 - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 / Phase 2 | Recruiting | InduPro, Inc. | 132 | 2026-07-08 | 2026-09-03 |
| Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers HIV (Human Immunodeficiency Virus), AIDS | Not yet recruiting | Shenzhen Third People's Hospital | 1000 | 2026-07-01 | 2026-07-10 | |
| ctHPVDNA Response-Adapted Chemoradiation +/- Retifanlimab Treatment in Locally-Advanced Anal Cancer HPV ctDNA Response based radiation, Chemotherapy, Retifanlimab - Anal Cancer, HPV-Related Carcinoma | Phase 2 | Recruiting | Jennifer Dorth | 33 | 2026-06-19 | 2026-08-14 |
| CASCADE: Testing for Safety and Immune Effects of PDS0101, an Anti-HPV Therapy, Among People Living With HIV PDS0101 - HPV Associated Cancers, HIV (Human Immunodeficiency Virus) | Phase 2 | Withdrawn | University of California, San Diego | 2026-04-30 | 2026-08-19 | |
| Assessment of Sexual Quality of Life Following Local Treatment (Radiotherapy With or Without Surgery) in Patients With HPV-positive Pelvic Cancer: a Descriptive Longitudinal Study Assessment of sexual quality of life - Pelvic Cancer, Anal Cancer | Not applicable | Not yet recruiting | Institut du Cancer de Montpellier - Val d'Aurelle | 42 | 2026-04-02 | 2026-04-13 |
| Sintilimab Versus Mitomycin in Combination With Capecitabine and IMRT for Limited-stage Anal Squamous Cell Carcinoma Intensity-Modulated Radiotherapy (IMRT), Capecitabine, Sintilimab - Anal Squamous Cell Carcinoma, Limited-stage | Phase 3 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 350 | 2026-03-17 | 2026-07-09 |
| Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer Biospecimen Collection, Prasterone, Survey Administration - Anal Carcinoma, Cervical Carcinoma | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 25 | 2026-03-12 | 2026-04-21 |
| Distance-Based Exercise to Preserve Function and Prevent Disability Exercise intervention, Telemedicine, Aerobic Exercise Intervention - Localized Malignant Solid Neoplasm, Anal Cancer | Not applicable | Recruiting | Alliance for Clinical Trials in Oncology | 104 | 2026-02-11 | 2026-10-02 |
| Self-sampling to Optimize Anal Lesion Outcomes Self-sampling, Nylon-flocked Swab - Anal Cancer | Not applicable | Recruiting | Medical College of Wisconsin | 572 | 2025-11-18 | 2026-05-12 |
| Beyond Survival: Addressing Gynecological and Sexual Health in Women After Radiotherapy for Anal Cancer Anal Cancer | Recruiting | Aarhus University Hospital | 80 | 2025-11-13 | 2025-12-22 | |
| A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas EVOLVE104 - Bladder Cancer, Squamous Cell Carcinoma of the Lung | Phase 1 | Recruiting | EvolveImmune United, Inc | 160 | 2025-11-13 | 2026-09-15 |
| Ganglion Impar Neurolysis for the Improvement of Radiation-Induced Pain During Localized Anal or Perianal Skin Cancer Treatment Electronic Health Record Review, Fluoroscopy, Ganglion Impar Neurolysis - Localized Anal Carcinoma, Localized Anal Margin Carcinoma | Not applicable | Recruiting | Emory University | 5 | 2025-11-10 | 2026-01-30 |
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Uterine Cervical Neoplasms (86) · Rectal Neoplasms (57) · Stomach Neoplasms (52) · Pancreatic Neoplasms (47) · Esophageal Neoplasms (46) · Vulvar Neoplasms (46) · Colonic Neoplasms (45) · Penile Neoplasms (40) · Breast Neoplasms (36) · Neoplasms (36) · Squamous Cell Carcinoma of Head and Neck (34) · Vaginal Neoplasms (33) · Prostatic Neoplasms (32) · Urinary Bladder Neoplasms (32)
Digestive System Diseases (294) · Digestive System Neoplasms (294) · Gastrointestinal Diseases (294) · Intestinal Diseases (294) · Neoplasms by Site (294) · Rectal Diseases (294) · Anus Diseases (293) · Intestinal Neoplasms (293) · Gastrointestinal Neoplasms (287) · Colorectal Neoplasms (264) · Neoplasms (258) · Rectal Neoplasms (237) · Urogenital Diseases (147) · Genital Diseases (141) · Urogenital Neoplasms (109)
Fluorouracil (26) · Mitomycin (18) · Radiotherapy (18) · Capecitabine (13) · Cisplatin (12) · pembrolizumab (11) · Cyclophosphamide (9) · Magnetic Resonance Spectroscopy (9) · Biopsy (8) · Paclitaxel (8) · Radiation (8) · Carboplatin (7) · Drug Therapy (7) · Nivolumab (7) · Specimen Handling (7)
National Cancer Institute (NCI) (22) · AIDS Malignancy Consortium (11) · M.D. Anderson Cancer Center (8) · Stanford University (6) · University Health Network, Toronto (5) · Aarhus University Hospital (4) · Medical College of Wisconsin (4) · Memorial Sloan Kettering Cancer Center (4) · Sahlgrenska University Hospital (4) · UNICANCER (4) · Alliance for Clinical Trials in Oncology (3) · Beijing Health Guard Biotechnology, Inc (3) · ECOG-ACRIN Cancer Research Group (3) · Incyte Corporation (3) · Jonsson Comprehensive Cancer Center (3)
United States (160) · France (26) · China (17) · Canada (15) · United Kingdom (14) · Australia (12) · Denmark (12) · Sweden (11) · Germany (10) · Spain (10) · Italy (9) · Belgium (7) · Brazil (6) · Norway (6) · Puerto Rico (6)
Joel Palefsky, MD (4) · Alan Nyitray, PhD (3) · Cathy Eng (3) · Mark Lane Welton (3) · Yongjiang Liu, Bachelor (3) · Charalampos Floudas, M.D. (2) · Christian S Hinrichs, MD (2) · Elizabeth Stier, MD (2) · Irving Salit, MD (2) · Jaffer A. Ajani, MD (2) · Jervoise Andreyev, MD (2) · Jian Zhang, Doctor (2) · Joseph A. Sparano, MD (2) · Lakshmi Rajdev (2)
PMID 23578724, PMID 28223062, PMID 18430910, PMID 20354531, PMID 20956625, PMID 28453692, PMID 31534737, PMID 32530769, PMID 8874455, PMID 12196376, PMID 12393999, PMID 15629599, PMID 17103253, PMID 18191265, PMID 18470481, PMID 19139424, PMID 19643599, PMID 19690306, PMID 19801930, PMID 20068553, PMID 20339140, PMID 20436836, PMID 20564111, PMID 20852198, PMID 21240983, PMID 21514072, PMID 22480131, PMID 23032420, PMID 23150707, PMID 23238584, PMID 23484057, PMID 23595039, PMID 24035327, PMID 24067488, PMID 25207403, PMID 25823737, PMID 26597443, PMID 27020837, PMID 27044938, PMID 27048903, PMID 27319286, PMID 27422279, PMID 27937092, PMID 28055103, PMID 28463160, PMID 28833949, PMID 28835533, PMID 29048177, PMID 29149611, PMID 29381586
U01CA121947 (8), UM1CA121947 (5), 2018 (4), U10CA180820 (4), 2015 (2), 2019 (2), P30CA015083 (2), P30CA016672 (2), P30CA068485 (2), K01AT008219 (1), N01CM00032 (1), N01CM00038 (1), N01CM00039 (1), N01CM00071 (1), N01CM00099 (1)