14 completed, 4 unknown, 2 suspended, 2 terminated. 10 Not applicable, 4 Phase 2, 1 Early Phase 1, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 4, Suspended 2, Terminated 2, Unknown 1, Withdrawn 1 |
| Phase 2 | 4 | Completed 4 |
| Early Phase 1 | 1 | Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Hypersomnia: new trials by email Literature Review of Hypersomnia trials Research Report on Hypersomnia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia) Modafinil, Modafinil Placebo, Solriamfetol - Long COVID, Long COVID-19 | Phase 2 | Completed | Duke University | 361 | 2024-08-12 | 2026-06-03 |
| RECOVER-SLEEP: Platform Protocol Modafinil, Modafinil Placebo, Solriamfetol - Long COVID, Long COVID-19 | Phase 2 | Completed | Duke University | 830 | 2024-07-31 | 2026-01-22 |
| Efficacy of the Dreem 3S Ambulatory Sleep Monitoring Device for the Evaluation of Narcolepsy Dreem 3S recording - Narcolepsy Type 1, Hypersomnia | Completed | Beacon Biosignals | 78 | 2024-07-01 | 2026-03-17 | |
| A Pilot Observational Study to Assess the Ability of Continuous 'Home' EEG to Accurately Diagnose Narcolepsy and Demonstrate Response to Treatment Narcolepsy Type 1, Hypersomnia | Unknown | Guy's and St Thomas' NHS Foundation Trust | 60 | 2023-09-01 | 2023-08-09 | |
| Disentangling the Role of Depression in Hypersomnia Sleep study - Hypersomnia | Completed | University of Pennsylvania | 54 | 2023-08-01 | 2026-08-06 | |
| Patient Outcomes in Unattended and In- Lab Polysomnography Attended Polysomnography in the Lab, Unattended Polysomnography in the Home - Sleep Apnea, Hypersomnia | Not applicable | Suspended | Cerebra Medical | 194 | 2023-08-01 | 2023-02-08 |
| Feasibility Study of At-Home EEG Monitoring for Hypersomnia Dreem 3 System At-Home Monitoring - Hypersomnia, Narcolepsy | Not applicable | Withdrawn | Kaiser Permanente | 2023-02-01 | 2024-05-14 | |
| Analysis of New Salivary Biomarkers to Evaluate Excessive Diurnal Sleepiness in Children With Hypersomnia saliva samples, Stanford sleepiness scale, Karolinska Sleepiness Scale - Hypersomnia, Sleepiness, Excessive Daytime | Completed | Hospices Civils de Lyon | 116 | 2022-04-11 | 2025-02-24 | |
| Evaluation of the Efficacy of Sodium Oxybate (Xyrem®) in Treatment of Post-traumatic Narcolepsy and Post-traumatic Hypersomnia Sodium Oxybate Oral Solution [Xyrem] - Hypersomnia, Narcolepsy | Early Phase 1 | Withdrawn | Brigham and Women's Hospital | 2020-09-01 | 2021-03-04 | |
| A Multi-Signal Based Monitoring System for CNS Hypersomnias Hypersomnia | Unknown | Chang Gung Memorial Hospital | 600 | 2020-06-04 | 2022-07-05 | |
| Telemedicine and Humidification for Cpap IN Osas Key Treatment (THINK Study) Telemedicine & Humidification - Sleep Apnea, Obstructive, OSA | Not applicable | Unknown | Andrea Romigi | 100 | 2020-06-01 | 2020-03-09 |
| The Music, Sleep and Dementia Study Tailored music listening intervention - Dementia, Alzheimer Disease | Not applicable | Completed | University of Pennsylvania | 32 | 2019-03-12 | 2021-01-13 |
| Sleep in Psychiatric Inpatients Sleep Disturbance, Sleep Disorder | Unknown | University of Zurich | 120 | 2018-08-31 | 2019-12-17 | |
| Importance of Sleep Deprivation in Differential Diagnosis of Primary Hypersomnia (Actisom dépistage) Hypersomnia | Completed | Centre d'Investigation Clinique et Technologique 805 | 100 | 2018-02-01 | 2021-01-26 | |
| Transcranial Direct Current Stimulation Therapy for Central Hypersomnia Without Cataplexy Transcranial Direct Current Stimulation, Sham stimulation - Hypersomnia | Not applicable | Terminated | Ohio State University | 39 | 2017-09-01 | 2021-10-25 |
| The Healthy Patterns Sleep Study Attention-Control Condition, Timed Activity Intervention - Dementia, Alzheimer Disease | Phase 3 | Completed | University of Pennsylvania | 421 | 2016-05-01 | 2024-07-26 |
| Sleep Disorders and Their Cardiovascular Correlates in Atahualpa. diagnostic test, Diagnostic test - Insomnia, Hypersomnia | Not applicable | Completed | Hospital Clínica Kennedy | 650 | 2013-06-01 | 2013-11-26 |
| Mindfulness Therapy on Disrupted Sleep in Bipolar Disorder Body Scan (BS) Meditation Intervention, Brief Supportive Psychotherapy (SP) - Bipolar Disorder, Insomnia | Not applicable | Completed | Massachusetts General Hospital | 48 | 2013-02-01 | 2016-06-24 |
| Structured Physical Activity for Sleep Quality and Daytime Sleepiness in Patients With Parkinson's Disease Structured Physical Activity, Sleep hygiene education - Parkinson's Disease, Poor Quality Sleep | Not applicable | Terminated | Northwestern University | 1 | 2011-08-01 | 2014-03-21 |
| Flumazenil for the Treatment of Primary Hypersomnia Flumazenil - Hypersomnia, Primary Hypersomnia | Phase 1 / Phase 2 | Completed | Lynn Marie Trotti | 10 | 2010-09-01 | 2017-12-12 |
Showing 20 of 24. Sign in to see all of them.
Disorders of Excessive Somnolence (24) · Sleep Initiation and Maintenance Disorders (7) · Sleep Wake Disorders (7) · Narcolepsy (5) · Parasomnias (3) · Sleep Disorders, Circadian Rhythm (3) · Alzheimer Disease (2) · Chronobiology Disorders (2) · Cognitive Dysfunction (2) · Dementia (2) · Dementia, Vascular (2) · Frontotemporal Dementia (2) · Idiopathic Hypersomnia (2) · Memory Disorders (2) · Neurocognitive Disorders (2)
Dyssomnias (24) · Sleep Disorders, Intrinsic (24) · Mental Disorders (23) · Nervous System Diseases (23) · Sleep Wake Disorders (17) · Pathological Conditions, Signs and Symptoms (9) · Neurologic Manifestations (7) · Signs and Symptoms (7) · Brain Diseases (5) · Central Nervous System Diseases (5) · Respiratory Tract Diseases (5) · Apnea (3) · Cardiovascular Diseases (3) · Cerebrovascular Disorders (3) · Neurodegenerative Diseases (3)
Modafinil (3) · solriamfetol (2) · Clarithromycin (1) · Flumazenil (1) · Melatonin (1) · Polysomnography (1) · Sodium Oxybate (1) · Transcranial Direct Current Stimulation (1)
University of Pennsylvania (3) · Duke University (2) · Lynn Marie Trotti (2) · Andrea Romigi (1) · Beacon Biosignals (1) · Brigham and Women's Hospital (1) · Centre d'Investigation Clinique et Technologique 805 (1) · Cerebra Medical (1) · Chang Gung Memorial Hospital (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Hospices Civils de Lyon (1) · Hospital Clínica Kennedy (1) · Kaiser Permanente (1) · Massachusetts General Hospital (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1)
United States (14) · France (3) · Canada (1) · Ecuador (1) · Switzerland (1) · Taiwan (1)
Christina Barkauskas, MD (2) · Lynn Marie Trotti, MD (2) · Susan Redline, MD MPH (2) · Dennis Hwang, MD (1) · Diego Centonze, PhD (1) · Jeanne F Duffy, PhD (1) · Nancy A. Hodgson (1) · Oscar H Del Brutto, MD (1) · Philip Gehrman, PhD (1) · Phyllis C Zee, MD, PhD (1) · Thilo Deckersbach, Ph.D. (1) · Ulysses Magalang, MD (1) · Yu-Shu Huang, PhD (1)
PMID 14023898, PMID 17552380, PMID 17969461, PMID 19238805, PMID 19423426, PMID 19742411, PMID 20123089, PMID 20181520, PMID 20465024, PMID 22178068, PMID 22995695, PMID 24587570, PMID 25009530, PMID 26094838, PMID 28465612, PMID 33608714, PMID 33853394, PMID 34031871, PMID 34344312, PMID 35878737, PMID 36000763, PMID 37470678, PMID 7979534, PMID 843779, PMID 9278632, PMID 9402885
2009 (1), 2017 (1), R01AG006072 (1), R01NR015226 (1)