52 completed, 5 terminated, 5 unknown, 3 not yet recruiting. 40 Not applicable, 13 Phase 3, 8 Phase 4, 6 Phase 2, 3 Phase 1.
Follow Diet, Sodium-Restricted: new trials by email Literature Review of Diet, Sodium-Restricted trials Research Report on Diet, Sodium-Restricted
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR). low sodium diet, high sodium diet, renal plasma flow - Genetics in Hypertension | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 110 | 2026-11-01 | 2026-09-22 |
| Low-Sodium Diet for Postpartum Blood Pressure Control Low Sodium Diet - Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe | Not applicable | Not yet recruiting | Women and Infants Hospital of Rhode Island | 110 | 2026-09-01 | 2026-08-12 |
| Genetic Architecture of Natriuretic Peptides and Blood Pressure Response Low Salt Diet, High Salt Diet, Saline Infusion - Hypertension (HTN), Cardiometabolic Diseases | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 200 | 2026-09-01 | 2026-03-10 |
| Salt Sensitivity Evaluation Via N-of-1 Trials (SENSE-Salt) High-Sodium Diet, Low-Sodium Diet - Salt-Sensitivity of Blood Pressure, Hypertension | Not applicable | Recruiting | Peking University | 72 | 2026-06-02 | 2026-08-31 |
| DiEtary Sodium Intake Effects on Ertugliflozin-induced Changes in GFR, reNal Oxygenation and Systemic Hemodynamics: the DESIGN Study, a Randomized, Placebo-controlled, Cross-over Study With Ertugliflozin in People With Type 2 Diabetes ertugliflozine, low salt diet, placebo - Type 2 Diabetes | Phase 4 | Recruiting | Amsterdam UMC, location VUmc | 34 | 2023-07-25 | 2025-05-21 |
| Effect of Low Salt and Ckd Progression Low salt diet - CKD Progression, Blood Pressure | Not applicable | Completed | Bangkok Metropolitan Administration Medical College and Vajira Hospital | 200 | 2023-02-28 | 2023-09-01 |
| Low-Salt Diet Effect on Th17-Mediated Inflammation and Vascular Reactivity in Psoriasis Low-Salt Diet - Psoriasis Vulgaris | Not applicable | Unknown | Josip Juraj Strossmayer University of Osijek | 50 | 2022-09-01 | 2023-06-09 |
| High Potassium Diet with Spices and Herbs As Salt Substitute for Lowering Blood Pressure in Older Adults: Study Protocol High Potassium, Low Sodium Diet, Standard Diet - Hypertension, Older Adults Institutionalized in Residential Homes | Not applicable | Completed | Universitas Airlangga | 62 | 2022-05-11 | 2024-11-12 |
| Surviving PEA in Roanoke (SPEAR) Study High Calcium, Low Sodium (HCLS) Crystalloid Therapy, High Calcium, High Sodium (HCHS) Crystalloid Therapy - Cardiac Arrest, Pulseless Electrical Activity | Phase 2 / Phase 3 | Recruiting | Carol Bernier | 342 | 2022-02-16 | 2022-03-17 |
| Renal Metabolism in Salt-sensitive Human Blood Pressure Low sodium diet, high sodium diet - Hypertension | Not applicable | Active not recruiting | Medical College of Wisconsin | 70 | 2021-11-01 | 2025-11-13 |
| CARDIA-Salt Sensitivity of Blood Pressure (SSBP) High Salt Diet, Low Salt Diet - Salt Sensitivity of Blood Pressure, Hypertension | Not applicable | Completed | Vanderbilt University Medical Center | 281 | 2021-05-17 | 2026-07-07 |
| Salt Intake, Microbiota, Immune Response and Endothelial Function in Hypertension Low salt diet plus sodium chloride supplements, Low salt diet plus placebo - Hypertension | Not applicable | Unknown | Hospital Clínico Universitario de Valladolid | 25 | 2020-12-01 | 2021-02-12 |
| Sodium Diet Effect on Aldosterone and Urinary RNA (SALTY) High-sodium diet 300 mmol sodium/day, Low-sodium diet 10 mmol sodium/day - Healthy | Not applicable | Completed | University of Michigan | 21 | 2020-02-12 | 2022-12-15 |
| Visualizing Vascular Mechanisms of Salt Sensitivity Low-salt diet, High-salt diet - Obesity, Cardiovascular Risk Factor | Not applicable | Completed | Vanderbilt University Medical Center | 19 | 2019-02-01 | 2026-04-23 |
| Low Sodium Diet in Oligohydramnios Assigned for Conservative Management low sodium diet - Oligohydramnios | Not applicable | Unknown | Wolfson Medical Center | 80 | 2019-02-01 | 2019-01-25 |
| Prospective Phenotyping of Autonomous Aldosterone Secretion Sodium loaded diet, Restricted sodium diet - Aldosterone Disorder, Adrenal Gland Disease | Active not recruiting | Brigham and Women's Hospital | 100 | 2018-06-15 | 2026-08-13 | |
| Gender Differences in Renal Functioning and Disease high-salt diet (V1) and low salt diet (V2), Contrast-enhanced ultrasound (CEUS), functional MRI - Chronic Renal Failure, Healthy Controls | Completed | Centre Hospitalier Universitaire Vaudois | 98 | 2017-05-30 | 2023-09-13 | |
| First in Human Single Ascending Dose Study of MOR107 MOR107, Placebo, Low sodium diet - Safety | Phase 1 | Terminated | Alan Richardson | 24 | 2017-02-16 | 2018-02-07 |
| Low Sodium vs. Regular Diet in Patients Admitted for Heart Failure Sodium Restricted Diet, Regular Diet - Heart Failure | Not applicable | Terminated | Maya Guglin | 13 | 2016-11-01 | 2021-04-22 |
| Sodium Lowering and Urinary Protein Reduction Trial Low Sodium Diet - Chronic Kidney Disease, Albuminuria | Phase 3 | Completed | Tulane University School of Public Health and Tropical Medicine | 151 | 2016-11-01 | 2022-12-21 |
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Hypertension (32) · Cardiovascular Diseases (11) · Heart Diseases (11) · Vascular Diseases (10) · Heart Failure (6) · Obesity (4) · Albuminuria (3) · Prehypertension (3) · Renal Insufficiency, Chronic (3) · Heart Failure, Diastolic (2) · Insulin Resistance (2) · Metabolic Syndrome (2) · Pre-Eclampsia (2) · Adrenal Gland Diseases (1) · Ascites (1)
National Heart, Lung, and Blood Institute (NHLBI) (7) · Brigham and Women's Hospital (4) · University of Michigan (4) · University of Minnesota (4) · Vanderbilt University (3) · Vanderbilt University Medical Center (3) · Regional Hospital Holstebro (2) · University of Alberta (2) · University of Parma (2) · Alan Richardson (1) · Amsterdam UMC, location VUmc (1) · Assistance Publique - Hôpitaux de Paris (1) · Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari (1) · Bangkok Metropolitan Administration Medical College and Vajira Hospital (1) · Burke Rehabilitation Hospital (1)
United States (29) · Denmark (4) · China (3) · Italy (3) · Netherlands (3) · Brazil (2) · Canada (2) · South Korea (2) · Switzerland (2) · Angola (1) · Australia (1) · Chile (1) · Croatia (1) · France (1) · Ireland (1)
Carolina C. Graffe, MD (3) · Erling B. Pedersen, Professor (3) · Albert Oberman (2) · Herbert Langford (2) · James M Luther, MD (2) · Richard Grimm (2) · Scott L Hummel, MD MS (2) · Adam Lewkowitz, MD (1) · Anand Vaidya, MD, MMSc (1) · Armando Coca, MD, MSc, phD (1) · Axel Mescheder, MD (1) · Berdine R Martin, PhD (1) · Bum Soon Choi, PhD (1) · Carol Bernier, DO (1)
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R01HL034767 (2), 2016 (1), 2023 (1), K23HL128909 (1), P01HL074940 (1), P20GM109036 (1), R01HL021823 (1), R01HL024999 (1), R01HL026585 (1), R01HL030171 (1), R01HL034659 (1), R01HL048641 (1), R01HL048642 (1), R01HL077525 (1), R01HL183814 (1)