336 completed, 40 unknown, 30 recruiting, 30 terminated. 481 Phase 2, 73 Phase 3, 72 Phase 1.
Follow Hyperinsulinism: new trials by email Literature Review of Hyperinsulinism trials Research Report on Hyperinsulinism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhibiting GABA Transaminase to Relieve Obesity Induced Hyperinsulinemia and Insulin Resistance Vigabatrin Pill, Placebo oral tablet - Hyperinsulinism, Insulin Resistance | Phase 2 | Withdrawn | University of Arizona | 2030-04-15 | 2025-07-30 | |
| The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction Caloric Restriction, Hyperglycemic clamp - Type2diabetes | Phase 2 | Not yet recruiting | Adrian Vella | 20 | 2027-12-15 | 2026-10-28 |
| Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus Semaglutide (Wegovy) weekly injection - Gestational Diabetes Mellitus (GDM), Metabolic Syndrome | Phase 2 / Phase 3 | Not yet recruiting | University of Massachusetts, Worcester | 226 | 2027-09-01 | 2026-09-28 |
| cfMSC Therapy for Diabetes cfMSC therapy for diabetes - Type II Diabetes Mellitus | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-11-02 |
| VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway Vericiguat 10 MG, Placebo, Insulin Sensitivity Test - Cardiovascular Diseases, Insulin Sensitivity/Resistance | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 200 | 2026-12-01 | 2026-01-23 |
| IGOB131 As A GLP-1 Modulator For Metabolic Disorders In Adults With Obesity IGOB131, Dextrin - Obesity & Overweight | Phase 2 | Not yet recruiting | University of Yaounde 1 | 80 | 2026-12-01 | 2026-10-20 |
| Relacorilant in Patients With Poorly Controlled Type 2 Diabetes and Autonomous Cortisol Secretion Relacorilant - Type 2 Diabetes, Hypercortisolism | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 34 | 2026-12-01 | 2026-11-09 |
| Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity Alpha-lipoic acid, Mirabegron, Placebo - Insulin Resistance, Obesity | Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 60 | 2026-11-17 | 2026-11-12 |
| Effects of Meal Macronutrients on Postprandial Lipids High carb then high fat breakfast, High fat then high carb breakfast - Nephrotic Syndrome, Lipodystrophy | Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 100 | 2026-11-17 | 2026-11-12 |
| Restoring Vascular and Insulin Function To Augment Anti-Amyloid Therapy in Alzheimer's Disease Empagliflozin, Insulin, Insulin Placebo - Alzheimer Disease | Phase 2 | Not yet recruiting | Wake Forest University Health Sciences | 30 | 2026-11-01 | 2026-09-30 |
| Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI) Galantamine Hydrobromide Extended Release - Spinal Cord Injury, Traumatic Spinal Cord Injury | Phase 2 / Phase 3 | Recruiting | Northwell Health | 60 | 2026-10-15 | 2026-11-04 |
| Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults Fish Oil, Corn oil control - Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) | Phase 2 | Recruiting | May Faraj, PDt, PhD | 84 | 2026-10-05 | 2026-10-08 |
| Studies of Insulin and Glucagon Action in the Liver Glucagon, Saline (placebo) - Diabetes (DM) | Phase 1 / Phase 2 | Not yet recruiting | Duke University | 40 | 2026-10-01 | 2026-08-05 |
| Tirzepatide for Treatment of CCCA Tirzepatide - Central Centrifugal Cicatricial Alopecia (CCCA) | Phase 2 | Recruiting | Johns Hopkins University | 20 | 2026-09-15 | 2026-11-03 |
| Exercise and Intranasal Insulin in Type 2 Diabetes Intranasal Insulin, Intranasal Placebo, High Intensity Exercise - Type 2 Diabetes, Insulin Sensitivity/Resistance | Phase 2 / Phase 3 | Recruiting | Rutgers, The State University of New Jersey | 60 | 2026-08-03 | 2026-06-30 |
| Effects of Curcumin-Piperine Supplementation in Fibromyalgia Curcumin - Piperine, Placebo - Fibromyalgia (FM) | Phase 2 | Not yet recruiting | Ain Shams University | 80 | 2026-08-01 | 2026-08-11 |
| Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes Tirzepatide 2.5mg weekly, Placebo injection (normal saline) - Type 1 Diabetes Mellitus | Phase 2 | Recruiting | Victor Chang Cardiac Research Institute | 44 | 2026-07-07 | 2026-09-16 |
| No Guts No Glory Probiotics Probiotic Formula, Placebo - Patients Using Olanzapine, Quetiapine, Risperidone or Clozapine | Phase 2 / Phase 3 | Recruiting | University Medical Center Groningen | 112 | 2026-06-01 | 2026-05-26 |
| Efficacy and Safety of Oral Controlled-release Nicotinic Acid (CIR-NA) for the Remission of Prediabetes. (CONCEPT) controlled-ileal-release nicotinic acid as multiple dose 100 mg/day, controlled-ileal-release nicotinic acid as multiple dose 200 mg/day, controlled-ileal-release nicotinic acid as multiple dose placebo - Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) | Phase 2 | Recruiting | University Hospital Schleswig-Holstein | 390 | 2026-03-03 | 2026-09-16 |
| Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes CIR-0602K, Placebo - Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus | Phase 2 | Recruiting | University of Virginia | 40 | 2026-02-22 | 2026-02-25 |
Showing 20 of 481. Sign in to see all of them.
Insulin Resistance (336) · Metabolic Syndrome (166) · Diabetes Mellitus, Type 2 (86) · Obesity (85) · Diabetes Mellitus (78) · Diabetes Mellitus, Type 1 (50) · Hypoglycemia (31) · Inflammation (31) · Glucose Intolerance (29) · Overweight (26) · Hypertension (25) · Non-alcoholic Fatty Liver Disease (19) · Cardiovascular Diseases (17) · Dyslipidemias (17)
Nutritional and Metabolic Diseases (480) · Glucose Metabolism Disorders (468) · Metabolic Diseases (468) · Endocrine System Diseases (203) · Pathological Conditions, Signs and Symptoms (163) · Signs and Symptoms (124) · Insulin Resistance (120) · Diabetes Mellitus (116) · Nutrition Disorders (111) · Body Weight (108) · Overnutrition (105) · Overweight (79) · Pathologic Processes (60) · Immune System Diseases (58)
Metformin (42) · Insulin (36) · Pioglitazone (17) · Exercise (14) · Cholecalciferol (12) · Glucagon (11) · Methods (9) · Rosiglitazone (9) · Insulin Lispro (8) · salicylsalicylic acid (8) · Atorvastatin (7) · Insulin Aspart (7) · Saline Solution (7) · Sodium Chloride (7) · Vitamin D (7)
Institut de Recherches Cliniques de Montreal (17) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (16) · University of Guadalajara (13) · Massachusetts General Hospital (9) · Children's Hospital of Philadelphia (6) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (6) · Albert Einstein College of Medicine (5) · Emory University (5) · Joslin Diabetes Center (5) · The University of Texas Health Science Center at San Antonio (5) · University of Aarhus (5) · University of Campinas, Brazil (5) · University of Pennsylvania (5) · Vanderbilt University Medical Center (5) · Radboud University Medical Center (4)
United States (226) · Canada (54) · Mexico (21) · Germany (19) · Denmark (18) · Italy (15) · Netherlands (14) · China (10) · France (9) · United Kingdom (9) · Spain (8) · Sweden (8) · Iran (7) · Norway (7) · Egypt (6)
Jack A Yanovski, M.D. (5) · Allison B. Goldfine, MD (4) · Raika Jamali, M.D. (4) · Rebecca J Brown, M.D. (4) · Steven J Russell, MD, PhD (4) · Bruno Geloneze, MD, PhD (3) · Remi Rabasa-Lhoret (3) · Valerio Nobili, MD (3) · Xu Lin, MD, PhD (3) · Adrian Vella (2)
PMID 17245174, PMID 19475464, PMID 19889232, PMID 20826632, PMID 21070531, PMID 25091629, PMID 36066991, PMID 37595266, PMID 10480510, PMID 10523015, PMID 10801260, PMID 10868854, PMID 10963727, PMID 11007769, PMID 11411567, PMID 11443202, PMID 11556815, PMID 11756340, PMID 11960602, PMID 12086935, PMID 12145010, PMID 12523673, PMID 12622244, PMID 12681026, PMID 12815141, PMID 1400291, PMID 14685229, PMID 15070752, PMID 15168555, PMID 15220351, PMID 15333514, PMID 15713712, PMID 15949871, PMID 16054141, PMID 16155076, PMID 16157765, PMID 16218959, PMID 16308421, PMID 16452557, PMID 16614616, PMID 16626303, PMID 16636217, PMID 16818482, PMID 16940989, PMID 16953201, PMID 1695875, PMID 17026483, PMID 17069794, PMID 17086191, PMID 17112576
2009 (2), 2017 (2), U01DK074556 (2), UL1RR024150 (2), 1UH3TR001372-01 (1), 2005 (1), 2008 (1), 2015 (1), 2016 (1), 2018 (1), 2019 (1), 2023 (1), 2025 (1), F32DK068902 (1), I01CX000982 (1)