199 completed, 17 withdrawn, 13 terminated, 9 unknown. 70 Phase 1, 61 Phase 4, 54 Phase 3, 32 Phase 2, 30 Not applicable.
Follow Insulin Lispro: new trials by email Literature Review of Insulin Lispro trials Research Report on Insulin Lispro
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Do Antipsychotics Block Insulin Action in the Brain: is it a Class Effect? Haloperidol, Placebo, Insulin Lispro - Brain Insulin Sensitivity, Healthy Controls | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 35 | 2025-12-11 | 2026-04-02 |
| Single vs Multi-Dose Insulin for Glycemic Control (SUGAR) Insulin glargine alone, Insulin glargine + insulin lispro - Diabetes in Pregnancy, Gestational Diabetes | Not applicable | Recruiting | Rutgers, The State University of New Jersey | 176 | 2025-11-26 | 2026-04-16 |
| Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes (START 2) Insulin - Gestational Diabetes, Pregnancy Related | Not applicable | Recruiting | Thomas Jefferson University | 430 | 2024-09-01 | 2024-11-22 |
| Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes Insulin - Gestational Diabetes, Pregnancy Related | Not applicable | Recruiting | Thomas Jefferson University | 430 | 2024-09-01 | 2024-11-21 |
| A Trial of Three- and Seven-days Insulin Infusions Set Mio Advanced infusions set, Novorapid, Extended wear insulin infusion (EWIS) - Type 1 Diabetes | Not applicable | Recruiting | Steno Diabetes Center Copenhagen | 80 | 2024-07-20 | 2024-08-06 |
| A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM) LY3938577, Placebo, Insulin Degludec - Healthy, Type 1 Diabetes Mellitus | Phase 1 | Completed | Eli Lilly and Company | 121 | 2024-05-15 | 2026-10-06 |
| Perioperative Glucose Monitoring and Treatment to Reduce Risk of Surgical Site Infections and Complications Insulin Lispro Injection, glucose testing - Surgical Site Infections, Stress Hyperglycemia | Not applicable | Unknown | St. Peter's Hospital, Albany, NY | 266 | 2024-04-09 | 2025-01-09 |
| Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec HDV-Lispro, Lispro - Diabetes Mellitus, Type 1 | Phase 2 | Completed | Diasome Pharmaceuticals | 227 | 2023-12-28 | 2026-07-31 |
| A Study of LY8888AX in Participants Using a Connected Insulin Management Platform Insulin Lispro, Tempo Smart Button, Dexcom G6 CGM - Type 1 Diabetes, Type 2 Diabetes | Not applicable | Completed | Eli Lilly and Company | 36 | 2023-10-05 | 2025-11-10 |
| Automated Fully Closed-Loop Insulin Delivery in Type 1 Diabetes With Ultra-Rapid Lispro (ACOLYTE Study) Lispro - Diabetes Mellitus, Type 1 | Not applicable | Unknown | Manchester University NHS Foundation Trust | 26 | 2023-07-21 | 2023-10-31 |
| Does Abnormal Insulin Action in the Brain Underlie Cognitive and Metabolic Dysfunction in Schizophrenia Intranasal insulin, Placebo - Schizophrenia, Healthy | Not applicable | Active not recruiting | Centre for Addiction and Mental Health | 20 | 2023-04-01 | 2026-09-25 |
| Ultrarapid Insulin Administered by a Bihormonal Closed Loop System in Patients With Type 1 Diabetes Insulin Lispro Cartridge [Lyumjev], Insulin Lispro Cartridge - Type 1 Diabetes | Not applicable | Completed | Inreda Diabetic B.V. | 12 | 2022-10-19 | 2026-02-17 |
| A Study of Insulin Efsitora Alfa (LY3209590) as a Weekly Basal Insulin Compared to Insulin Glargine in Adult Participants With Type 2 Diabetes on Multiple Daily Injections Insulin Efsitora Alfa, Insulin Lispro (U100), Insulin Glargine (U100) - Type 2 Diabetes, Type 2 Diabetes Treated With Insulin | Phase 3 | Completed | Eli Lilly and Company | 730 | 2022-08-11 | 2025-04-27 |
| Efficacy and Safety of Dapagliflozin for the Hospital Management of Patients With Type 2 Diabetes Dapagliflozin, Glargine - Type2diabetes, Coronary Artery Disease | Phase 4 | Completed | Medanta, The Medicity, India | 250 | 2022-07-29 | 2023-10-19 |
| SITAgliptin Plus GLARgine to Glycemic Control in the Hospital Setting (SITAGLAR-H) Sitagliptin 100mg, Glargine, Lispro - Type 2 Diabetes | Phase 4 | Completed | Hospital de Especialidades, Centro Medico Nacional "La Raza", Instituto Mexicano del Seguro Social | 76 | 2022-07-06 | 2023-09-26 |
| A Trial Investigating the Pharmacodynamics of BC Combo THDB0207 Compared With Humalog® Mix25 and Simultaneous Injections of Humalog® and Lantus® in Healthy Chinese Volunteers Euglycemic clamp with BC Combo THDB0207, Euglycemic clamp with Humalog® Mix25, Euglycemic clamp with Humalog® and Lantus® - Healthy | Phase 1 | Completed | Adocia | 27 | 2022-05-12 | 2023-10-12 |
| A Trial Comparing the Pharmacodynamics and Pharmacokinetics of BC Combo THDB0207 and Lantus® and Humalog® in Subjects With Type 1 Diabetes Euglycemic clamp with BC Combo THDB0207, Euglycemic clamp with Lantus®, Euglycemic clamp with Humalog® - Type 1 Diabetes | Phase 1 | Completed | Adocia | 30 | 2022-05-12 | 2023-09-15 |
| Efficacy and Safety of THDB0206 Compared to Insulin Lispro Injection in Participants With Type 2 Diabetes THDB0206 Injection, Insulin Lispro Injection - Type 2 Diabetes | Phase 3 | Completed | Tonghua Dongbao Pharmaceutical Co.,Ltd | 1040 | 2022-05-06 | 2025-12-22 |
| Efficacy and Safety of THDB0206 Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes THDB0206, Insulin Lispro, Insulin Glargine - Type 1 Diabetes | Phase 3 | Completed | Tonghua Dongbao Pharmaceutical Co.,Ltd | 550 | 2022-04-13 | 2025-12-15 |
| A Study of LY900014 (Lyumjev) Versus Insulin Lispro (Humalog) in Participants With Type 1 Diabetes Lyumjev with 50% basal rate reduction, Humalog with 50% basal rate reduction, Humalog with 100% basal rate reduction - Diabetes Mellitus, Type 1 | Phase 1 | Completed | Eli Lilly and Company | 25 | 2022-02-14 | 2024-09-03 |
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Diabetes Mellitus, Type 1 (115) · Diabetes Mellitus, Type 2 (70) · Diabetes Mellitus (56) · Insulin Resistance (33) · Hyperglycemia (12) · Diabetes, Gestational (8) · Hypoglycemia (4) · Metabolic Diseases (3) · Motor Activity (3) · Cognitive Dysfunction (2) · Coronary Artery Disease (2) · Metabolic Syndrome (2) · Alzheimer Disease (1) · Asthma (1) · Dementia, Vascular (1)
Eli Lilly and Company (79) · Adocia (18) · Halozyme Therapeutics (12) · Sanofi (11) · Emory University (9) · Biodel (8) · Diasome Pharmaceuticals (4) · Mannkind Corporation (4) · Medical University of Warsaw (4) · Wockhardt (4) · Centre for Addiction and Mental Health (3) · Tonghua Dongbao Pharmaceutical Co.,Ltd (3) · Albert Einstein College of Medicine (2) · AstraZeneca (2) · Dance Biopharm Inc. (2)
United States (118) · Germany (61) · Spain (27) · Mexico (24) · Canada (23) · Poland (21) · Hungary (18) · Brazil (16) · China (16) · Italy (16) · Russia (16) · Romania (15) · Argentina (14) · France (14) · Puerto Rico (14)
Grit Andersen, MD (9) · Guillermo Umpierrez, MD (4) · Douglas Muchmore, M.D. (3) · Agnieszka Szypowska (2) · Douglas Muchmore, MD (2) · Eugen Baumgaertner, MD (2) · Kristin Castorino, DO (2) · Linda A Morrow, M.D. (2) · Linda Morrow, MD (2) · Marcus Hompesch, M.D. (2) · Maya Fayfman, MD (2)
PMID 34041713, PMID 36542287, PMID 23101951, PMID 28417532, PMID 28587667, PMID 29167192, PMID 32940537, PMID 38035641, PMID 39963952, PMID 15745837, PMID 15951574, PMID 17909083, PMID 17989308, PMID 18227478, PMID 18795211, PMID 19017777, PMID 19246588, PMID 19276235, PMID 19336625, PMID 19459762, PMID 19797280, PMID 19885269, PMID 19929994, PMID 20150302, PMID 20199136, PMID 20204386, PMID 20536953, PMID 20546262, PMID 20685497, PMID 20920045, PMID 21078733, PMID 21270182, PMID 21273493, PMID 21288502, PMID 21355716, PMID 21454236, PMID 21457066, PMID 21593301, PMID 21714645, PMID 22136324, PMID 22374642, PMID 22672081, PMID 23040716, PMID 23043164, PMID 23489710, PMID 23514728, PMID 23601190, PMID 23712381, PMID 23757434, PMID 23877988
2015 (10), 2017 (7), 2014 (3), 2019 (2), R01DK077166 (2), 1UC4DK108612-01 (1), 2009 (1), 2016 (1), 2018 (1), 2023 (1), K23DK124647 (1), K23HD103875 (1)