15 completed, 4 terminated, 3 withdrawn, 1 active not recruiting. 26 Phase 2, 4 Phase 1, 4 Phase 3.
Follow Heart Failure, Diastolic: new trials by email Literature Review of Heart Failure, Diastolic trials Research Report on Heart Failure, Diastolic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF Henggliflozin Combined with Probiotics, Henggliflozin, double placebo - Heart Failure, Preserved Ejection Fraction | Phase 1 / Phase 2 | Not yet recruiting | The First Affiliated Hospital of Air Force Medicial University | 162 | 2026-07-01 | 2026-07-07 |
| Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension JK07 - HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction | Phase 2 | Withdrawn | Salubris Biotherapeutics Inc | 2025-12-15 | 2026-05-15 | |
| Chronic Exogenous Ketosis in HFpEF Exogenous Ketone Drink, Placebo - Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction | Phase 2 | Enrolling by invitation | Duke University | 20 | 2025-07-28 | 2026-10-14 |
| Allopurinol Improves Heart Function in African Americans With Resistant Hypertension Allopurinol - Heart Failure Preserved Ejection Fraction, Resistant Hypertension | Phase 2 | Completed | VA Office of Research and Development | 40 | 2024-09-30 | 2026-09-04 |
| Study of JK07 in Patients With Chronic Heart Failure JK07, Placebo - Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction | Phase 2 | Active not recruiting | Salubris Biotherapeutics Inc | 282 | 2024-03-28 | 2026-05-22 |
| Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF) Tovinontrine (CRD-750), Placebo - Heart Failure, Heart Failure Preserved Ejection Fraction | Phase 2 | Completed | Cardurion Pharmaceuticals, Inc. | 303 | 2024-02-13 | 2026-09-01 |
| A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction Low calorie meal replacement plan, Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography - Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic | Phase 2 / Phase 3 | Completed | University of Leicester | 66 | 2023-12-05 | 2026-07-22 |
| Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES Sulforaphane - Diastolic Dysfunction, Systolic Dysfunction | Phase 1 / Phase 2 | Withdrawn | Texas Tech University Health Sciences Center | 2022-07-01 | 2026-06-29 | |
| Stratified Treatment to Ameliorate Diastolic Left Ventricular Stiffness in Heart Failure With Preserved Ejection Fraction Dapagliflozin, Placebo - Heart Failure, Diastolic | Phase 2 | Unknown | Mariëlle Scheffer | 26 | 2020-07-01 | 2020-09-22 |
| CoQ10 and D-ribose in Patients With Diastolic Heart Failure CoQ10, D-Ribose Oral Powder, Placebo pills - Heart Failure, Diastolic | Phase 2 | Completed | University of Kansas Medical Center | 216 | 2018-02-05 | 2022-03-18 |
| Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs Allogeneic Derived Cells, Placebo/Control Arm - Congestive Heart Failure, Heart Failure, Diastolic | Phase 2 | Completed | Cedars-Sinai Medical Center | 27 | 2017-07-12 | 2024-07-25 |
| Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF KNO3, KCl - Heart Failure, Diastolic Heart Failure | Phase 2 | Completed | University of Pennsylvania | 12 | 2015-01-01 | 2017-10-03 |
| Interleukin-1 Blockade in HF With Preserved EF Anakinra, Placebo - Heart Failure With Normal Ejection Fraction | Phase 2 | Completed | Virginia Commonwealth University | 31 | 2014-09-01 | 2018-06-19 |
| Study of the Effect of Eplerenone on Heart Function in Women Receiving Anthracycline Chemotherapy for Breast Cancer Eplerenone, Placebo - Breast Cancer | Phase 2 / Phase 3 | Terminated | University of British Columbia | 44 | 2014-05-01 | 2017-01-05 |
| If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Ivabradine, Placebo - Diastolic Heart Failure | Phase 2 | Withdrawn | St Vincent's University Hospital, Ireland | 2012-12-01 | 2014-11-25 | |
| Inhaled Nitrite in Subjects With Pulmonary Hypertension Inhaled Nitrite - Pulmonary Hypertension, Heart Failure, Diastolic | Phase 2 | Completed | Schmidhofer, Mark, MD | 48 | 2012-06-01 | 2019-03-28 |
| Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction renal denervation - Diastolic Heart Failure, Hypertension | Phase 2 / Phase 3 | Terminated | UMC Utrecht | 60 | 2012-04-01 | 2021-05-03 |
| Radiofrequency-based Speckle Tracking Echocardiography to Evaluate Diastolic Function Echocardiography system Ultra DCI Model 5000, Echocardiography machine GE Vivid E9, Diastolic function assessment - Heart Failure, Diastolic | Phase 1 / Phase 2 | Completed | University of Michigan | 50 | 2010-08-01 | 2023-10-16 |
| Ranolazine in Diastolic Heart Failure Ranolazine, Saline 0.9% and placebo tablet - Diastolic Heart Failure | Phase 2 | Completed | Gilead Sciences | 20 | 2010-04-01 | 2012-07-12 |
| Metoprolol XR in Heart Failure With Normal Ejection Fraction Metoprolol XR - Diastolic Heart Failure | Phase 2 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 102 | 2010-01-01 | 2019-03-21 |
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Heart Failure (11) · Hypertension, Pulmonary (3) · Fibromatosis, Gingival, 2 (2) · Heart Failure, Systolic (2) · Hypertension (2) · Atrial Fibrillation (1) · Atrial Flutter (1) · Breast Neoplasms (1) · Bronchiolitis Obliterans Syndrome (1) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Diabetes Mellitus, Type 2 (1) · Heart Diseases (1) · Heart Murmurs (1)
Cardiovascular Diseases (25) · Heart Diseases (25) · Heart Failure (15) · Vascular Diseases (6) · Lung Diseases (4) · Respiratory Tract Diseases (4) · Hypertension (3) · Pathological Conditions, Signs and Symptoms (3) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2) · Pathologic Processes (2) · Signs and Symptoms (2) · Acid-Base Imbalance (1) · Acidosis (1) · Arrhythmias, Cardiac (1)
alagebrium (2) · Allopurinol (1) · Diagnostic Imaging (1) · Diet (1) · Echocardiography (1) · Electrocardiography (1) · Eplerenone (1) · Hematologic Tests (1) · Interleukin 1 Receptor Antagonist Protein (1) · Ivabradine (1) · Ketones (1) · Perhexiline (1) · Positron-Emission Tomography (1) · Potassium Chloride (1) · Probiotics (1)
Salubris Biotherapeutics Inc (2) · Cardiovascular Clinical Sciences Inc (1) · Cardurion Pharmaceuticals, Inc. (1) · Cedars-Sinai Medical Center (1) · Duke University (1) · Gilead Sciences (1) · Mariëlle Scheffer (1) · Massachusetts General Hospital (1) · Pfizer (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Schmidhofer, Mark, MD (1) · St Vincent's University Hospital, Ireland (1) · Synvista Therapeutics, Inc (1) · Texas Tech University Health Sciences Center (1) · The First Affiliated Hospital of Air Force Medicial University (1)
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Antonio Abbate, MD, PhD (1) · Benjamin Van Tassell, PharmD (1) · Bertram Pitt, MD (1) · Brandon Atkins (1) · Dermot J McCaffrey, MB MRCPI FRACP (1) · Gerry P McCann, MD (1) · Janet Pierce, PhD (1) · Julio A Chirinos, MD (1) · Lars S. Maier, MD (1) · Louis J Dell'Italia, MD (1) · Marc A. Simon, MD (1) · Marc J S, MD (1) · Margot Davis, MD (1) · Michael P Frenneaux, MBBS MD (1) · Michael Zile, MD (1)
PMID 21538388, PMID 21709061, PMID 23883653, PMID 24621836, PMID 24720918, PMID 25495811, PMID 27812547, PMID 27927683, PMID 28475816, PMID 29606104, PMID 30354558, PMID 35644694, PMID 39880434
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