4 completed, 3 active not recruiting, 3 terminated, 2 unknown. 6 Phase 2, 5 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Active not recruiting 2, Terminated 2, Completed 1, Withdrawn 1 |
| Phase 1 | 5 | Active not recruiting 2, Completed 2, Withdrawn 1 |
| Phase 3 | 2 | Terminated 1, Unknown 1 |
Follow Fibromatosis, Gingival, 2: new trials by email Literature Review of Fibromatosis, Gingival, 2 trials Research Report on Fibromatosis, Gingival, 2
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension JK07 - HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction | Phase 2 | Withdrawn | Salubris Biotherapeutics Inc | 2025-12-15 | 2026-05-15 | |
| Study of JK07 in Patients With Chronic Heart Failure JK07, Placebo - Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction | Phase 2 | Active not recruiting | Salubris Biotherapeutics Inc | 282 | 2024-03-28 | 2026-05-22 |
| Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation HMBD-001, Docetaxel, Nab-paclitaxel - Non-Small Cell Lung Cancer, Pancreatic Cancer | Phase 1 | Active not recruiting | Hummingbird Bioscience | 68 | 2023-09-06 | 2025-04-18 |
| Single-Ascending Dose Study of JK07 in Subjects With HFpEF JK07, Matching Placebo - Heart Failure With Preserved Ejection Fraction | Phase 1 | Withdrawn | Salubris Biotherapeutics Inc | 2022-10-21 | 2023-05-31 | |
| A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours HMBD-001, HMBD-001 and enzalutamide - Bladder Cancer, Triple Negative Breast Cancer | Phase 1 / Phase 2 | Active not recruiting | Cancer Research UK | 81 | 2021-11-10 | 2025-08-11 |
| Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors Seribantumab - Locally Advanced Solid Tumor, Metastatic Solid Tumor | Phase 2 | Terminated | Elevation Oncology | 54 | 2020-09-29 | 2025-04-03 |
| Study of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) JK07, Matching Placebo - Heart Failure With Reduced Ejection Fraction | Phase 1 | Completed | Salubris Biotherapeutics Inc | 14 | 2020-09-21 | 2025-07-09 |
| Neuregulin-1 in Patient With Different Forms of Cardiovascular Diseases: a Pilot Study Neuregulin-1β level in plasma - Heart Failure With Preserved Ejection Fraction, Microvascular Angina | Completed | I.M. Sechenov First Moscow State Medical University | 100 | 2019-03-01 | 2023-05-03 | |
| Survival Study of the Recombinant Human Neuregulin-1β in Subjects With Chronic Heart Failure. rhNRG-1, Placebo - Chronic Heart Failure | Phase 3 | Unknown | Zensun Sci. & Tech. Co., Ltd. | 1600 | 2018-07-23 | 2024-02-01 |
| Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS) Cardiac Arrest, Inflammation | Recruiting | MaineHealth | 400 | 2016-01-01 | 2025-07-18 | |
| A Phase 2 Study of MM-141 Plus Nab-paclitaxel and Gemcitabine in Front-line Metastatic Pancreatic Cancer MM-141, Placebo, Gemcitabine - Pancreatic Cancer | Phase 2 | Completed | Merrimack Pharmaceuticals | 88 | 2015-05-01 | 2018-09-18 |
| A Study of MM-121 in Combination With Chemotherapy Versus Chemotherapy Alone in Heregulin Positive NSCLC MM-121, Docetaxel - Non-Small Cell Lung Cancer, NSCLC | Phase 2 | Terminated | Elevation Oncology | 153 | 2015-02-01 | 2021-10-12 |
| Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients rhNRG-1, Placebo - Chronic Heart Failure | Phase 3 | Terminated | Zensun Sci. & Tech. Co., Ltd. | 679 | 2012-02-01 | 2017-12-21 |
| A Neurobiological Study on Heterogeneity of Schizophrenia: Genetic Variations and Neurobiological Differentiations Schizophrenia | Unknown | National Taiwan University Hospital | 360 | 2009-03-01 | 2010-03-08 | |
| Phase I Study of U3P1287/01, Including Patients With Advanced Solid Tumors U3-1287 (AMG888) - Advanced Solid Tumors | Phase 1 | Completed | U3 Pharma GmbH | 60 | 2008-08-01 | 2010-07-29 |
Heart Failure (4) · Pancreatic Neoplasms (4) · Carcinoma, Non-Small-Cell Lung (3) · Esophageal Neoplasms (2) · Heart Failure, Diastolic (2) · Heart Failure, Systolic (2) · Hypertension, Pulmonary (2) · Lethal Congenital Contracture Syndrome 2 (2) · Neoplasm Metastasis (2) · Ovarian Neoplasms (2) · Urinary Bladder Neoplasms (2) · Adenocarcinoma (1) · Atrial Fibrillation (1) · Atrial Flutter (1)
Cardiovascular Diseases (6) · Heart Diseases (6) · Lung Diseases (6) · Respiratory Tract Diseases (6) · Neoplasms (5) · Neoplasms by Site (5) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Endocrine Gland Neoplasms (4) · Endocrine System Diseases (4) · Pancreatic Diseases (4) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Respiratory Tract Neoplasms (4) · Thoracic Neoplasms (4)
130-nm albumin-bound paclitaxel (2) · Docetaxel (2) · Gemcitabine (2) · seribantumab (2) · Albumin-Bound Paclitaxel (1) · Istiratumab (1) · enzalutamide (1) · patritumab (1)
Salubris Biotherapeutics Inc (4) · Elevation Oncology (2) · Zensun Sci. & Tech. Co., Ltd. (2) · Cancer Research UK (1) · Hummingbird Bioscience (1) · I.M. Sechenov First Moscow State Medical University (1) · MaineHealth (1) · Merrimack Pharmaceuticals (1) · National Taiwan University Hospital (1) · U3 Pharma GmbH (1)
United States (9) · Canada (4) · China (3) · Australia (2) · Germany (2) · Spain (2) · United Kingdom (2) · France (1) · Hungary (1) · Poland (1) · Puerto Rico (1) · Russia (1) · South Korea (1) · Taiwan (1)
Wilson Tang, MD (2) · Anastasia Shchendrygina (1) · David B Seder, MD (1) · Hai-Gwo Hwu, Professor (1) · Johann de Bono, Prof (1) · Runlin Gao, MD, Ph.D (1) · Runlin Gao, Ph.D,MD (1) · Sergey Ryzhov, MD, PhD (1)
PMID 23591447, PMID 30975923, PMID 31237169, PMID 31912800, PMID 38325139, PMID 40737710, PMID 41428976
P20GM139745 (1)