14 completed, 5 unknown, 4 terminated, 2 active not recruiting. 11 Phase 4, 8 Phase 3, 3 Phase 1, 3 Phase 2, 1 Not applicable.
Follow colistinmethanesulfonic acid: new trials by email Literature Review of colistinmethanesulfonic acid trials Research Report on colistinmethanesulfonic acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia colistimethate sodium, 0.9% Saline - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Not yet recruiting | University Hospital Fattouma Bourguiba | 400 | 2027-01-01 | 2026-10-08 |
| Study on the Safety and Efficacy of Polymyxin E2 Methanesulfonate for Injection in the Treatment of Hospital-Acquired Bacterial Pneumonia/Ventilator-Associated Bacterial Pneumonia Caused by Carbapenem-Resistant Gram-Negative Bacteria TQD3524, Meropenem for injection, Colistimethate Sodium for Injection - Hospital-acquired Bacterial Pneumonia/Ventilator-associated Bacterial Pneumonia | Phase 2 | Recruiting | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 48 | 2026-07-21 | 2026-09-04 |
| Colistin and Meropenem Versus Amikacin and Meropenem for MDR Gram Negative Bacteria Regarding Efficacy and Safety. Colistimethate sodium for injection, meropenem, Amikacin Injection and meropenem - MDR Bacteria | Phase 4 | Active not recruiting | Beni-Suef University | 100 | 2025-12-30 | 2026-07-14 |
| Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial Colistimethate sodium (CMS) - Ventilator-Associated Pneumonia (VAP) | Not applicable | Recruiting | Qilu Hospital of Shandong University | 508 | 2025-07-15 | 2026-05-19 |
| Comparative Study of Clinical Outcomes and Safety Between Colistin and Tigecycline Colistimethate Sodium, Tigecycline - Infection in ICU | Phase 4 | Active not recruiting | Beni-Suef University | 132 | 2024-12-01 | 2025-03-25 |
| Comparing Tigecycline Vs. Colistimethate in CNS Infections Tigecycline (Tygacil), Colistimethate sodium (CMS) - Central Nervous System Infections | Not yet recruiting | Ain Shams University | 70 | 2024-12-01 | 2024-11-25 | |
| A Clinical Trial for the Treatment of Carbapenem Resistant Gram-negative Bacterial Infection With Colistimethate Sodium for Injection Colistimethate sodium for injection, Meropenem for Injection, Coly Mycin M Injectable Product - Mental Health Issue | Phase 3 | Unknown | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 80 | 2023-07-06 | 2024-01-10 |
| Colistin Monotherapy vs Colsitin-fosfomycine in CRAB Infection Colistin Sodium Methanesulfonate, Colistin Sodium Methanesulfonate plus Fosfomycin - Infection Due to Carbapenem Resistant Acinetobacter | Phase 4 | Unknown | Chiang Mai University | 188 | 2023-04-01 | 2024-08-26 |
| Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infection Colistin, Minocycline, Placebo - Acinetobacter Infections | Phase 4 | Unknown | Mahidol University | 94 | 2023-01-10 | 2023-01-18 |
| Pharmacokinetics of Colistin in Critically Ill Patients With Extracorporeal Membrane Oxygenation Colistin - Colistin | Phase 4 | Terminated | St. Anne's University Hospital Brno, Czech Republic | 8 | 2022-09-01 | 2024-01-31 |
| Pharmacokinetics of Colistin in Critically-ill Patients With AKI Who Receive SLED Colistin Sulfomethate - Bacterial Infections | Phase 4 | Completed | Mahidol University | 13 | 2021-10-18 | 2022-11-28 |
| Efficacy and Safety of Inhaled CMS in Bronchiectasis Subjects With Chronic P. Aeruginosa Infection. (PROMIS-I) CMS, Placebo - Non Cystic Fibrosis Bronchiectasis | Phase 3 | Completed | Zambon SpA | 377 | 2017-06-06 | 2023-11-15 |
| Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infections Colistimethate Sodium - Gram-Negative Bacterial Infections, Pediatric Cancer | Phase 4 | Completed | National Cancer Institute, Egypt | 70 | 2017-01-01 | 2020-09-16 |
| A Study of DEcolonization in Patients With HAematological Malignancies (DEHAM) Colistimethate Sodium - Hematological Infection | Phase 4 | Completed | Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology | 62 | 2017-01-01 | 2017-12-28 |
| Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonates Aerosolized plus intravenous colistin, Intravenous colistin - Pneumonia, Ventilator-Associated, Colistin Adverse Reaction | Phase 3 | Terminated | Hat Yai Medical Education Center | 204 | 2016-09-01 | 2018-08-02 |
| Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) Versus Colistimethate Sodium+Imipenem+Cilastatin in Imipenem-Resistant Bacterial Infection (MK-7655A-013) Imipenem+Cilastatin/Relebactam, Colistimethate sodium (CMS), Imipenem+Cilastatin - Bacterial Infections | Phase 3 | Completed | Merck Sharp & Dohme LLC | 50 | 2015-08-21 | 2018-10-19 |
| Impact of Plasma Levels of Colistin in Patients With Carbapenem Resistant Acinetobacter Baumannii Infection colistimethate sodium - Acinetobacter Infections | Completed | DongGuk University | 30 | 2015-05-01 | 2018-06-26 | |
| A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) plazomicin, colistin, meropenem - Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE | Phase 3 | Completed | Achaogen, Inc. | 69 | 2014-09-16 | 2018-10-16 |
| Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients colistin - Gram Negative Bacterial Infections | Phase 4 | Unknown | Hospital Barros Luco Trudeau | 200 | 2014-04-01 | 2018-03-13 |
| Evaluation of Inhaled Antibiotics on Bacterial Diversity and Richness in the Cystic Fibrosis Lung TOBI™ Podhaler™ 112 mg inhaled twice daily, Colistimethate 75 mg inhaled two times daily - Cystic Fibrosis | Terminated | Dartmouth-Hitchcock Medical Center | 1 | 2014-04-01 | 2018-03-12 |
Showing 20 of 29. Sign in to see all of them.
Pneumonia (5) · Pneumonia, Ventilator-Associated (4) · Bacterial Infections (3) · Critical Illness (3) · Cystic Fibrosis (3) · Gram-Negative Bacterial Infections (3) · Healthcare-Associated Pneumonia (3) · Acinetobacter Infections (2) · Pseudomonas Infections (2) · Sepsis (2) · Cellulitis (1) · Central Nervous System Infections (1) · Cross Infection (1) · Infections (1) · Intraabdominal Infections (1)
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (3) · Beni-Suef University (2) · Mahidol University (2) · Achaogen, Inc. (1) · Ain Shams University (1) · Chiang Mai University (1) · Dartmouth-Hitchcock Medical Center (1) · DongGuk University (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · GlaxoSmithKline (1) · Hat Yai Medical Education Center (1) · Hospital Barros Luco Trudeau (1) · Merck Sharp & Dohme LLC (1) · Mical Paul (1) · Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology (1)
Thailand (5) · China (4) · United States (4) · Egypt (3) · Greece (3) · Israel (3) · Italy (3) · Spain (3) · Australia (2) · Germany (2) · Switzerland (2) · United Kingdom (2) · Belarus (1) · Belgium (1) · Bulgaria (1)
Adhiratha Boonyasiri, MD (2) · Athitaya Luangnara (1) · Hao Wang, Professor (1) · Ihar Iskrou, Ph.D. (1) · Johan Mouton, MD PhD (1) · Keith S Kaye, MD, MPH (1) · Loreto Rojas, MD, PhD (1) · Lynn E Connolly, MD, PhD (1) · Mical Paul, MD (1) · Narongsak Nakwan, MD (1)
PMID 21995648, PMID 23616495, PMID 27098822, PMID 28614995, PMID 29456043, PMID 29755707, PMID 30462182, PMID 31254273, PMID 31400759, PMID 32094127, PMID 32154325, PMID 33789574, PMID 34775134, PMID 37518089, PMID 37538951, PMID 41194117
2015 (2)