24 completed, 9 unknown, 2 recruiting, 2 terminated. 15 Phase 4, 10 Phase 3, 5 Not applicable, 4 Phase 2, 3 Phase 1.
Follow Imipenem: new trials by email Literature Review of Imipenem trials Research Report on Imipenem
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Efficacy and Safety of (Meropenem + Colistin) Versus (Imipenem/Cilastatin + Tigecycline) on Eradication of Multi-Drug Resistance Bacteria "Imipenem/cilastatin" and "Tigecycline", "colistin" and "meropenem" - MDR Bacteria | Phase 2 | Not yet recruiting | Ain Shams University | 60 | 2026-04-01 | 2026-04-13 |
| A Trial of HRS-8427 in the Treatment of Adults With Complicated Urinary Tract Infection, Including Acute Pyelonephritis HRS-8427, Imipenem and Cilastatin Sodium, HRS-8427 placebo - Complicated Urinary Tract Infection(cUTI), Including Acute Pyelonephritis(AP) | Phase 3 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 579 | 2024-09-25 | 2026-09-30 |
| Preventive Effect of Prophylactic Oral Antibiotics Against Cholangitis After Kasai Portoenterostomy Basic treatment: sulperazone + ursodeoxycholic acid + compound glycyrrhizin + methylprednisolone + vitamin AD , D , E , K + imipenem or meropenem, Prophylactic oral antibiotics: compound sulfamethoxazole tablet (SMZ/TMP) + cefaclor - Biliary Atresia, Cholangitis | Not applicable | Recruiting | Children's Hospital of Fudan University | 356 | 2023-07-01 | 2026-05-15 |
| Impact of Obesity on the Pharmacokinetics of Imipenem-Relebactam in ICU Patients Imipenem/Cilastatin/Relebactam 1.25g - Obesity, Critical Illness | Phase 4 | Withdrawn | University of Illinois at Chicago | 2023-01-01 | 2024-11-27 | |
| Intrapulmonary Pharmacokinetics of XNW4107, Imipenem and Cilastatin in Healthy Subjects XNW4107, Imipenem/Cilastatin - Bacterial Infections | Phase 1 | Completed | Evopoint Biosciences Inc. | 21 | 2021-03-25 | 2023-02-16 |
| Pharmacokinetics of XNW4107 in Subjects With Various Degrees of Renal Function XNW4107, Imipenem/Cilastatin - Bacterial Infections | Phase 1 | Completed | Evopoint Biosciences Inc. | 39 | 2021-02-25 | 2023-02-16 |
| Finding the Optimal Regimen for Mycobacterium Abscessus Treatment Amikacin, Tigecycline, Imipenem - Pulmonary Disease Due to Mycobacteria (Diagnosis) | Phase 2 / Phase 3 | Recruiting | The University of Queensland | 300 | 2020-03-02 | 2026-05-11 |
| A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonitis Presenting With Septic Shock. Imipenem, Tigecycline, GMCSF - Spontaneous Bacterial Peritonitis | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 90 | 2019-12-20 | 2021-02-16 |
| Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex Sulbactam, Durlobactam, Colistin - Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia | Phase 3 | Completed | Entasis Therapeutics | 207 | 2019-09-05 | 2023-02-01 |
| Temocillin Versus a Carbapenem as Initial Intravenous Treatment for ESBL Related Urinary Tract Infections Temocillin, meropenem or imipenem - Urinary Tract Infections | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 29 | 2019-01-04 | 2025-11-20 |
| Antibacterial Prophylaxis vs no Prophylaxis for Hematological Malignancies Patients Before Allo-HSCT Imipenem - Antibacterial Prophylaxis, Hematological Malignancies | Phase 2 / Phase 3 | Unknown | Nanfang Hospital, Southern Medical University | 250 | 2018-12-01 | 2018-11-07 |
| PK/PD and Clinial Outcomes of Beta-lactams in ICU Patients Meropenem, Imipenem - Critical Illness, Bacterial Infections | Unknown | Prince of Songkla University | 102 | 2018-09-01 | 2020-05-01 | |
| The Analysis of Factors Influencing the Vd of Imipenem in Septic Shock Patients Imipenem - Septic Shock | Completed | Southeast University, China | 25 | 2018-03-18 | 2021-01-05 | |
| Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis ceftriaxone, ciprofloxacin, imipenem - Mechanical Ventilation Complication, Critical Illness | Phase 4 | Terminated | University Hospital, Lille | 103 | 2018-02-08 | 2025-12-11 |
| Population Pharmacokinetics of Anti-infective Drugs in Children With Infectious Diseases cephalosporins,penicillins,macrolides,carbapenems and antiviral drugs - Children; Infection | Unknown | Beijing Children's Hospital | 800 | 2017-06-21 | 2017-12-19 | |
| Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens Polymyxin B - Trauma, Resistant Infection | Phase 3 | Unknown | University of Puerto Rico | 40 | 2017-05-25 | 2019-02-08 |
| Evidence Based Management of Acute Biliary Pancreatitis serum lipase or amylase, ultrasound, CT - Acute Pancreatitis | Completed | Zagazig University | 30 | 2017-05-15 | 2020-11-05 | |
| Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae Antipseudomonal beta-lactam antibiotic, De-escalation(short-spectrum antibiotic) - Enterobacteriaceae Infections | Phase 3 | Completed | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 344 | 2016-10-01 | 2020-07-17 |
| Evaluation of Innovative Tools in Development of Antibiotics Ciprofloxacin, Imipenem - Pneumonia | Phase 1 | Completed | Medical University of Vienna | 10 | 2016-05-29 | 2021-09-01 |
| Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Cefoxitin, imipenem - Urinary Tract Infections | Phase 4 | Terminated | Central Hospital, Nancy, France | 6 | 2016-03-01 | 2017-08-11 |
Showing 20 of 39. Sign in to see all of them.
Infections (5) · Critical Illness (4) · Pneumonia (4) · Pneumonia, Ventilator-Associated (4) · Bacterial Infections (3) · Urinary Tract Infections (3) · Bacteremia (2) · Lung Diseases (2) · Pancreatitis (2) · Pneumonia, Bacterial (2) · Sepsis (2) · Biliary Atresia (1) · Cholangitis (1) · Communicable Diseases (1) · Disease (1)
Prince of Songkla University (4) · Merck Sharp & Dohme LLC (3) · Assistance Publique - Hôpitaux de Paris (2) · Evopoint Biosciences Inc. (2) · Institute of Liver and Biliary Sciences, India (2) · Southeast University, China (2) · Ain Shams University (1) · Beijing Children's Hospital (1) · Central Hospital, Nancy, France (1) · Children's Hospital of Fudan University (1) · Chinese PLA General Hospital (1) · Entasis Therapeutics (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Jiangsu HengRui Medicine Co., Ltd. (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1)
China (8) · Thailand (7) · United States (6) · France (4) · India (3) · Egypt (2) · Israel (2) · Puerto Rico (2) · Spain (2) · Taiwan (2) · Australia (1) · Austria (1) · Belarus (1) · Brazil (1) · Croatia (1)
Sutep Jaruratanasirikul, M.D. (2) · A-Dong Shen, Master (1) · Ahlem Trifi (1) · Anthony J Schaeffer, MD (1) · Claudio Puoti, Prof (1) · Davor Stimac, MD, PhD (1) · Dr Ankur Jindal, MD (1) · Jason Le (1) · Juan M Maldonado Lozada, PharmD (1) · Liu Qifa (1)
PMID 12749509, PMID 15269195, PMID 17121631, PMID 18199038, PMID 18436554, PMID 18444865, PMID 18625681, PMID 19374579, PMID 20175247, PMID 21793988, PMID 22252816, PMID 22752516, PMID 23254142, PMID 23394211, PMID 23616495, PMID 23697744, PMID 23896955, PMID 24054878, PMID 24191943, PMID 24514083, PMID 24903189, PMID 25048851, PMID 25155587, PMID 25327505, PMID 25430979, PMID 25461655, PMID 25628457, PMID 25904407, PMID 26259799, PMID 26289222, PMID 26474358, PMID 26529126, PMID 26755499, PMID 27033711, PMID 27418577, PMID 28249572, PMID 28575389, PMID 28592230, PMID 28601833, PMID 29507070, PMID 30962334, PMID 31404018, PMID 32029130, PMID 32129861, PMID 32176787, PMID 32277344, PMID 32785589, PMID 32886347, PMID 33020163, PMID 33413809
2015 (1), 2016 (1), 2017 (1)