6 completed, 2 recruiting, 1 enrolling by invitation, 1 withdrawn. 10 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 6, Recruiting 2, Enrolling by invitation 1, Withdrawn 1 |
Follow Frontotemporal Lobar Degeneration: new trials by email Literature Review of Frontotemporal Lobar Degeneration trials Research Report on Frontotemporal Lobar Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial Lemborexant 5 MG - Insomnia, Dementia | Phase 4 | Recruiting | Nova Scotia Health Authority | 1 | 2023-12-11 | 2025-02-21 |
| Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech AV-1451 - PPA, Non-fluent Aphasia | Phase 4 | Recruiting | Mayo Clinic | 50 | 2018-07-01 | 2025-11-12 |
| Lithium As a Treatment to Prevent Impairment of Cognition in Elders Lithium Carbonate, Placebo oral capsule - Mild Cognitive Impairment | Phase 4 | Completed | Ariel Gildengers, MD | 83 | 2018-02-02 | 2025-09-11 |
| Efficacy of Pain Treatment on Depression in Patients With Dementia Paracetamol, Buprenorphine, Paracetamol placebo - Depression, Pain | Phase 4 | Completed | University of Bergen | 163 | 2014-08-01 | 2017-04-04 |
| Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease Memantine - Alzheimer's Disease | Phase 4 | Completed | Shanghai Mental Health Center | 26 | 2008-07-01 | 2010-12-03 |
| Imaging of Brain Amyloid Plaques in the Aging Population Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451) - Alzheimer's Disease, Dementia With Lewy Bodies | Phase 4 | Enrolling by invitation | Mayo Clinic | 8000 | 2008-04-01 | 2026-06-23 |
| Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia memantine, Placebo pill - Frontal Lobe Dementia, Frontotemporal Lobe Dementia | Phase 4 | Completed | University of California, San Francisco | 81 | 2007-10-01 | 2020-11-17 |
| Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia Citalopram - Frontotemporal Dementia | Phase 4 | Completed | Sunnybrook Health Sciences Centre | 22 | 2006-09-01 | 2017-05-05 |
| Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD) Amantadine, Placebo - Dementia | Phase 4 | Withdrawn | Johns Hopkins University | 2005-09-01 | 2017-08-14 | |
| A 52 Week Open Label Trial of Memantine for Frontotemporal Lobar Degeneration Memantine - Frontotemporal Lobar Degeneration | Phase 4 | Completed | University of California, San Francisco | 2004-05-01 | 2012-11-12 |
Dementia (7) · Frontotemporal Dementia (6) · Alzheimer Disease (4) · Cognitive Dysfunction (2) · Dementia, Vascular (2) · Lewy Body Disease (2) · Mental Disorders (2) · Agnosia (1) · Aphasia (1) · Aphasia, Broca (1) · Aphasia, Primary Progressive (1) · Apraxias (1) · Dementia, Multi-Infarct (1) · Depression (1)
Brain Diseases (10) · Central Nervous System Diseases (10) · Nervous System Diseases (10) · Neurocognitive Disorders (10) · Neurodegenerative Diseases (10) · Metabolic Diseases (9) · Nutritional and Metabolic Diseases (9) · Proteostasis Deficiencies (9) · TDP-43 Proteinopathies (9) · Mental Disorders (8) · Tauopathies (4) · Dementia (3) · Pathological Conditions, Signs and Symptoms (3) · Arterial Occlusive Diseases (2)
Memantine (3) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Acetaminophen (1) · Amantadine (1) · Buprenorphine (1) · Citalopram (1) · Lithium Carbonate (1) · lemborexant (1) · tau Proteins (1)
Mayo Clinic (2) · University of California, San Francisco (2) · Ariel Gildengers, MD (1) · Johns Hopkins University (1) · Nova Scotia Health Authority (1) · Shanghai Mental Health Center (1) · Sunnybrook Health Sciences Centre (1) · University of Bergen (1)
United States (5) · Canada (2) · China (1) · Norway (1)
Adam L. Boxer, M.D., Ph.D. (1) · Ane Erdal, PhD candidate (1) · Ariel Gildengers, MD (1) · Bruce Miller, M.D. (1) · David M Blass, M.D. (1) · Elisabeth Flo, PhD (1) · Jennifer Whitwell, PhD (1) · Krista Lanctot, PhD (1) · Nathan Herrmann, MD (1) · Shifu Xiao, MD. PhD. (1) · Val Lowe, M.D. (1)
PMID 19812461, PMID 21878805, PMID 23290598, PMID 29487556, PMID 29725986, PMID 33189083, PMID 40501510, PMID 41770546
R01AG011378 (1), R01AG055389 (1), R01DC012519 (1), U01AG006786 (1)