77 completed, 27 unknown, 13 terminated, 11 recruiting. 139 Phase 2, 43 Phase 1, 14 Phase 3.
Follow Foot Ulcer: new trials by email Literature Review of Foot Ulcer trials Research Report on Foot Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Performance of ComBatic™ Antimicrobial Wound Care Products in Hard-to-Heal Wounds Irrigation Solution for wounds, Hydrogel for wound care - Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer), Chronic Wound Care | Phase 2 | Not yet recruiting | University of Calgary | 96 | 2027-01-01 | 2026-10-14 |
| Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Diabetic Foot Ulcers PRFM, Standard of Care (SoC) - Diabetic Foot Ulcer (DFU), Ulcer | Phase 1 / Phase 2 | Not yet recruiting | Tiger Biosciences, LLC. | 55 | 2026-09-01 | 2026-09-25 |
| Standard Treatment Associated With Phage Therapy Versus Placebo for Diabetic Foot Ulcers Infected by S. Aureus Topical anti-Staphylococcus bacteriophage therapy, Topical placebo corresponding to anti-Staphylococcus bacteriophage therapy - Diabetic Foot, Staphylococcal Infections | Phase 1 / Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire de Nīmes | 60 | 2026-09-01 | 2026-03-20 |
| The Effect of L-Carnitine on Wound Healing in Patients With Diabetic Foot Ulcer. L- carnitine - Diabetic Foot Ulcer, Diabetic Foot Ulcer (DFU) | Phase 2 | Recruiting | Ain Shams University | 50 | 2026-09-01 | 2026-08-17 |
| Phase 2a Dose Finding Study of Nu-3 Gel in Subjects With Mild iDFU Antimicrobial agent - Diabetic Foot Ulcers (DFUs) | Phase 2 | Recruiting | Lakewood-Amedex Inc | 24 | 2026-08-14 | 2026-09-02 |
| Controlled Trial to Evaluate the Safety and Efficacy of CYWC628 (Human Dermal Fibroblast Spheroids) for the Treatment of Refractory Diabetic Foot Ulcers Compared With Standard of Care Standard of Care (SOC), SoC + Low dose CYWC628, SoC + High dose CYWC628 - Diabetic Foot Ulcer (DFU) | Phase 1 / Phase 2 | Recruiting | FibroBiologics | 120 | 2026-06-01 | 2026-08-26 |
| Effects of Transcutaneous Photobiomodulation on Diabetic Foot Ulcers. PBM - Photobiomodulation, Placebo PBM, Standard Treatment - Diabetes Mellitus, Foot Ulcer | Phase 2 | Recruiting | University of Nove de Julho | 20 | 2026-05-12 | 2026-09-04 |
| Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers ELU42 Topical Spray - Diabetic Foot Ulcer, Wagner Grade 1 - 2 | Phase 1 / Phase 2 | Recruiting | Eluciderm Inc | 15 | 2025-11-10 | 2026-02-12 |
| Safety and Preliminary Efficacy of TrophiPatch, an Adipose-Derived Stromal Cell Patch for Chronic Leg Ulcers TrophiPatch: allogeneic adipose-derived stromal cell patch - Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU) | Phase 1 / Phase 2 | Recruiting | Nicolò Brembilla | 18 | 2025-07-01 | 2025-07-02 |
| Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care. Platelet Rich Plasma - Diabetic Foot Ulcer, Type 1 Diabetes Mellitus | Phase 2 | Recruiting | Estar Medical dba Medical Technologies, LTD | 30 | 2025-04-15 | 2025-06-12 |
| A Phase 2a Proof of Concept Open-Label, Randomized, Controlled Study to Evaluate the Safety and Efficacy of MDI-1228-mesylate Gel Compared With Standard of Care Alone in Patients With Diabetic Foot Ulcers 0.75% MDI-1228_mesylate gel plus Standard of Care, Standard of Care Alone - Diabetic Foot Ulcer | Phase 2 | Recruiting | Zhuhai Rui-Inno Pharmaceutical Technology Co., Ltd. | 60 | 2025-03-12 | 2025-03-07 |
| Evaluation of the Safety and Efficacy of Live ASCs in the Treatment of Diabetic Foot Syndrome. Allogeneic ADSC/ASC (alloADSC-DFU-RL), Placebo (PL-DFU-RL) - Diabetic Foot Ulcer | Phase 2 | Recruiting | Medical University of Warsaw | 105 | 2025-03-05 | 2026-10-26 |
| Evaluate the Efficacy and Safety of Xianglei Tangzu Gao for the Treatment of Wagner Grade II Diabetic Foot Ulcers Xianglei Tangzu Gao, Vehicle Cream - Diabetic Foot Ulcer | Phase 2 / Phase 3 | Active not recruiting | Oneness Biotech Co., Ltd. | 120 | 2024-08-16 | 2026-06-12 |
| Stem Cell Derived Exome for Treatment of Diabetic Foot Skin drug prepared with exome originated from stem cell - Diabetic Foot, Stem Cell | Phase 1 / Phase 2 | Not yet recruiting | Second Affiliated Hospital of Guangzhou Medical University | 50 | 2024-08-01 | 2024-06-28 |
| Safety and Efficacy of Stem Cells for Diabetic Foot Ulcer Allogeneic mesenchymal stem cells (MSCs), Normal Saline - Diabetic Foot Ulcer | Phase 1 / Phase 2 | Unknown | Supergenics Life Science Sdn. Bhd. | 22 | 2024-05-01 | 2024-03-06 |
| BB-101 for the Treatment of Diabetic Lower Leg and Foot Ulcers BB-101 - Diabetic Foot Ulcer | Phase 2 | Recruiting | Blue Blood Biotech Corp. | 96 | 2024-05-01 | 2026-10-02 |
| Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU) PEP (Purified Exosome Product) / TISSEEL - Diabetic Foot Ulcer | Phase 2 | Completed | Rion Inc. | 59 | 2024-02-27 | 2026-07-20 |
| Phase II Study to Evaluate Efficacy and Safety of AMP Peptide PL-5 in Mild Infections of Diabetic Foot Ulcers Antimicrobial Peptide PL-5 Topical Spray and Placebo - Diabetic Foot Ulcers | Phase 2 | Active not recruiting | Jiangsu ProteLight Pharmaceutical & Biotechnology Co., Ltd. | 90 | 2024-01-30 | 2025-05-25 |
| Evaluation of AUP12602-C as New Topical Treatment for DFUs (DIAMEND STUDY) AUP1602-C, Placebo - Diabetic Foot Ulcer | Phase 2 | Completed | Aurealis Oy | 64 | 2023-07-21 | 2026-02-12 |
| Painless Sharp Wound Debridement With Lidocaine-23%-Tetra-caine-7% Gel Versus EMLA 5% Cream IMP2 (lidocaine-23%-tetracaine-7% gel), IMP1 (EMLA 5% cream) - Ulcus Cruris, Ecthyma | Phase 2 | Unknown | Juerg Hafner | 40 | 2023-06-01 | 2023-06-06 |
Showing 20 of 139. Sign in to see all of them.
Diabetic Foot (131) · Diabetes Mellitus (35) · Ulcer (13) · Wounds and Injuries (11) · Leg Ulcer (9) · Infections (7) · Chronic Limb-Threatening Ischemia (5) · Diabetes Complications (5) · Peripheral Vascular Diseases (5) · Pressure Ulcer (5) · Varicose Ulcer (5) · Diabetic Neuropathies (4) · Bronchiolitis Obliterans Syndrome (3) · Diabetes Mellitus, Type 2 (3)
Skin and Connective Tissue Diseases (139) · Skin Diseases (138) · Skin Ulcer (136) · Endocrine System Diseases (134) · Cardiovascular Diseases (131) · Vascular Diseases (131) · Leg Ulcer (130) · Diabetic Angiopathies (129) · Diabetic Neuropathies (127) · Diabetes Complications (126) · Diabetes Mellitus (100) · Nutritional and Metabolic Diseases (37) · Glucose Metabolism Disorders (36) · Metabolic Diseases (36)
Standard of Care (16) · Levofloxacin (3) · Saline Solution (3) · Sodium Chloride (3) · 2-(2-(4-chlorophenyl)ethoxy)adenosine (2) · Becaplermin (2) · Dalteparin (2) · Doxycycline (2) · Metformin (2) · Anti-Infective Agents (1) · Arginine (1) · Ascorbic Acid (1) · Atorvastatin (1) · Bandages (1) · Carnitine (1)
Pfizer (4) · Anterogen Co., Ltd. (3) · Baylor College of Medicine (3) · GlaxoSmithKline (3) · Innocoll (3) · Aurealis Oy (2) · Celularity Incorporated (2) · Chinese University of Hong Kong (2) · Hadassah Medical Organization (2) · Hanan Jafar (2) · Lakewood-Amedex Inc (2) · Medical University of Warsaw (2) · OcuNexus Therapeutics, Inc. (2) · Oneness Biotech Co., Ltd. (2) · PluroGen Therapeutics, Inc (2)
United States (51) · Germany (10) · China (7) · Poland (7) · United Kingdom (7) · Taiwan (6) · Israel (5) · Russia (5) · Czechia (4) · France (4) · India (4) · Italy (4) · Spain (4) · Sweden (4) · Austria (3)
David Prior (3) · Robert S Kirsner, MD, PhD (2) · Abdallah Awidi, MD (1) · Adrianne P Smith, MD (1) · Albert Sotto, MD, PhD (1) · Alexander M. Reyzelman, DPM (1) · Alireza Goodarzi, MSc (1) · Amira Motawea (1) · Andreas Kerstan, Dr. (1) · Andres Gutierrez, M.D., Ph.D. (1) · Andrew J Boulton, Professor (1) · Antonio Chacon, MD, PhD (1) · Antonio de la Cuesta, MD (1)
PMID 15504999, PMID 20923537, PMID 22284892, PMID 22289660, PMID 22463944, PMID 22659765, PMID 22672145, PMID 23216959, PMID 24330156, PMID 24760263, PMID 25411598, PMID 26116717, PMID 26696670, PMID 27638453, PMID 29564750, PMID 30679183, PMID 30943782, PMID 33011075, PMID 33407796, PMID 33504262, PMID 33646060, PMID 33735146, PMID 34052927, PMID 34398099, PMID 34488845, PMID 35507774, PMID 35844773, PMID 36064604, PMID 37480520, PMID 37740111, PMID 38216296, PMID 39313976, PMID 39740667, PMID 39838970, PMID 39964684, PMID 41077558
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