Foot Ulcer: Clinical Trials

533 completed, 203 unknown, 121 recruiting, 94 terminated. 564 Not applicable, 139 Phase 2, 87 Phase 1, 76 Phase 3, 63 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	564	Completed 271, Unknown 97, Recruiting 72, Terminated 47, Not yet recruiting 34, Active not recruiting 19, Withdrawn 18, Enrolling by invitation 4, Suspended 2
Phase 2	139	Completed 77, Unknown 27, Terminated 13, Recruiting 11, Not yet recruiting 5, Active not recruiting 3, Withdrawn 3
Phase 1	87	Completed 37, Unknown 26, Terminated 7, Active not recruiting 5, Recruiting 5, Not yet recruiting 4, Withdrawn 2, Suspended 1
Phase 3	76	Completed 38, Terminated 18, Unknown 10, Recruiting 5, Active not recruiting 2, Not yet recruiting 2, Withdrawn 1
Phase 4	63	Completed 31, Unknown 11, Terminated 8, Recruiting 7, Withdrawn 4, Active not recruiting 1, Not yet recruiting 1
Early Phase 1	12	Unknown 6, Completed 3, Not yet recruiting 1, Recruiting 1, Withdrawn 1

Follow Foot Ulcer: new trials by email Literature Review of Foot Ulcer trials Research Report on Foot Ulcer

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
On the Move: Center and Home-Based Exercise to Enhance Mobility in Diabetic Foot Ulcer Recovery 12-week exercise regimen, 12-week standard of care - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	University of Maryland, Baltimore	60	2027-06-01	2026-10-07
Placental Cells for Diabetic Foot Ulcers Placenta Stem Cells - Diabetic Foot Ulcer	Phase 1	Not yet recruiting	Wake Forest University Health Sciences	12	2027-03-01	2026-10-23
Clinical Performance of ComBatic™ Antimicrobial Wound Care Products in Hard-to-Heal Wounds Irrigation Solution for wounds, Hydrogel for wound care - Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer), Chronic Wound Care	Phase 2	Not yet recruiting	University of Calgary	96	2027-01-01	2026-10-14
Subcutaneous Dexpanthenol Administration and Wound Epithelialization Dexpanthenol, Standard Wound Care - Chronic Wounds, Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Dilara CANBAY OZDEMIR	40	2026-12-02	2026-10-22
Clinical Efficacy of Modified Simiao Yongan Decoction and Endovascular Therapy for Diabetic Foot Ulcers Modified Simiao Yongan Decoction, Endovascular Therapy and Standard Care - Diabetic Foot Ulcer, Damp-Heat Toxins Accumulation Syndrome	Not applicable	Not yet recruiting	Chengdu University of Traditional Chinese Medicine	120	2026-12-01	2026-09-08
18F-FDG PET/CT for Diagnosis of Diabetic Foot Osteomyelitis 18F-FDG PET/CT - Diabetic Foot Infections		Not yet recruiting	Jewish General Hospital	150	2026-11-01	2026-09-18
Comparison of Negative Pressure Wound Therapy Versus Moist Wound Dressing in Diabetic Foot Ulcer Patients Negative Pressure Wound Therapy, Moist Wound Dressing - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Abbas Institute of Medical Sciences	60	2026-11-01	2026-10-28
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery Diabetic Foot Ulcer, Wound Healing		Recruiting	Universidade Sao Francisco	40	2026-10-21	2026-10-22
Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer	Phase 4	Not yet recruiting	First Affiliated Hospital of Wenzhou Medical University	180	2026-10-20	2026-09-18
a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers Standard of Care, BIOxHEAL (human amniotic membrane allograft) - Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft	Phase 3	Recruiting	Applied Biologics, LLC	253	2026-10-08	2026-10-16
Activity Reduction vs Advice for Plantar Hotspots in Diabetes Individualized Objectively Monitored Activity Reduction, Standard Activity-Reduction Advice - Diabetic Foot, Diabetic Peripheral Neuropathy	Not applicable	Not yet recruiting	Shifa International Hospital	100	2026-10-01	2026-09-25
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System in the Healing of Diabetic Foot Ulcers Syntrfuge Microfragmented Fat, Standard of Care - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	62	2026-09-30	2026-08-21
Nutritional Status in Adults With Diabetic Foot Ulcers Protein supplementation and nutrition education - Diabetic Foot Ulcers (DFU), Nutrition Assessment		Not yet recruiting	Hvidovre University Hospital	30	2026-09-21	2026-09-18
Effect of Digital-Supported Foot Care Education in Individuals With Type 2 Diabetes Digital-Supported Foot Care Education - Type 2 Diabetes Mellitus (T2DM)	Not applicable	Not yet recruiting	Siirt University	90	2026-09-20	2026-09-10
Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds Biodynamik XT3 - Diabetic Foot Ulcer, Chronic Ulcers of the Lower Limb	Not applicable	Recruiting	Biodynamik, Inc	100	2026-09-15	2026-09-14
DiaFootCare to Promote Self-Care of Diabetic Foot Ulcers in Oman DiaFootCare Mobile Application, Usual Diabetic Foot Care - Diabetic Foot Ulcer (DFU), Diabetes Mellitus	Not applicable	Not yet recruiting	Oman Ministry of Health	139	2026-09-13	2026-09-29
The ProActive Study- Integrating a Proactive and Palliative Care Approach to Diabetic Ulcer Care Diabetic Foot Ulcer (DFU), Palliative Care		Not yet recruiting	Ulla Riis Madsen	484	2026-09-01	2026-08-24
Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Diabetic Foot Ulcers PRFM, Standard of Care (SoC) - Diabetic Foot Ulcer (DFU), Ulcer	Phase 1 / Phase 2	Not yet recruiting	Tiger Biosciences, LLC.	55	2026-09-01	2026-09-25
Standard Treatment Associated With Phage Therapy Versus Placebo for Diabetic Foot Ulcers Infected by S. Aureus Topical anti-Staphylococcus bacteriophage therapy, Topical placebo corresponding to anti-Staphylococcus bacteriophage therapy - Diabetic Foot, Staphylococcal Infections	Phase 1 / Phase 2	Not yet recruiting	Centre Hospitalier Universitaire de Nīmes	60	2026-09-01	2026-03-20
Evaluation of a Paraclinical Test for the Diagnosis of Arterial Insufficiency in Diabetic Patients With Foot Ulcers Handheld Doppler - Arterial Insufficiency	Not applicable	Not yet recruiting	Groupe Hospitalier de la Rochelle Ré Aunis	84	2026-09-01	2026-07-28

Showing 20 of 1093. Sign in to see all of them.

Narrower conditions

Diabetic Foot (1031)  ·  Diabetes Mellitus (241)  ·  Varicose Ulcer (77)  ·  Ulcer (63)  ·  Wounds and Injuries (55)  ·  Pressure Ulcer (54)  ·  Diabetic Neuropathies (50)  ·  Diabetes Complications (49)  ·  Diabetes Mellitus, Type 2 (48)  ·  Leg Ulcer (48)  ·  Peripheral Arterial Disease (32)  ·  Chronic Limb-Threatening Ischemia (23)  ·  Infections (21)  ·  Osteomyelitis (19)

Broader conditions

Skin and Connective Tissue Diseases (1093)  ·  Skin Diseases (1088)  ·  Skin Ulcer (1074)  ·  Endocrine System Diseases (1058)  ·  Leg Ulcer (1045)  ·  Cardiovascular Diseases (1038)  ·  Vascular Diseases (1035)  ·  Diabetic Angiopathies (1020)  ·  Diabetes Complications (983)  ·  Diabetic Neuropathies (982)  ·  Diabetes Mellitus (822)  ·  Nutritional and Metabolic Diseases (286)  ·  Metabolic Diseases (277)  ·  Glucose Metabolism Disorders (276)

Interventions

Standard of Care (90)  ·  Bandages (15)  ·  Negative-Pressure Wound Therapy (12)  ·  Sodium Chloride (10)  ·  Control Groups (9)  ·  Debridement (8)  ·  Educational Status (8)  ·  Collagenases (7)  ·  Becaplermin (6)  ·  Extracorporeal Shockwave Therapy (6)  ·  Hyperbaric Oxygenation (6)  ·  Low-Level Light Therapy (6)  ·  Saline Solution (6)  ·  Exercise (5)  ·  Hydrogels (5)

Sponsors

University of Texas Southwestern Medical Center (17)  ·  Integra LifeSciences Corporation (15)  ·  Universidad Complutense de Madrid (14)  ·  Anterogen Co., Ltd. (10)  ·  Smith & Nephew, Inc. (10)  ·  ConvaTec Inc. (9)  ·  Healthpoint (9)  ·  MiMedx Group, Inc. (9)  ·  Molnlycke Health Care AB (9)  ·  University of Michigan (9)  ·  Assiut University (8)  ·  Cairo University (8)  ·  Centre Hospitalier Universitaire de Nīmes (8)  ·  Oneness Biotech Co., Ltd. (8)  ·  Organogenesis (7)

Countries

United States (382)  ·  United Kingdom (63)  ·  France (51)  ·  China (48)  ·  Turkey (Türkiye) (46)  ·  Germany (40)  ·  Spain (40)  ·  Canada (38)  ·  Italy (33)  ·  Egypt (31)  ·  Denmark (29)  ·  Sweden (27)  ·  Taiwan (24)  ·  Israel (21)  ·  Poland (19)

Top investigators

Herbert B Slade, MD (7)  ·  David Armstrong, DPM, MD, PhD (6)  ·  Lawrence Lavery, DPM MPH (5)  ·  Chandan K Sen, PhD (4)  ·  Lawrence Lavery, DPM (4)  ·  Windy Cole, DPM (4)  ·  Brian Schmidt, DPM (3)  ·  Charles M Zelen, DPM (3)  ·  Charles Zelen, DPM (3)  ·  David G Armstrong, DPM, MD, PhD (3)  ·  David Prior (3)  ·  Isabel CN Sacco, PhD (3)  ·  Jie Shen (3)

Results publications

PMID 28614678, PMID 16291066, PMID 23958264, PMID 24767584, PMID 26738255, PMID 27269974, PMID 34187716, PMID 35534614, PMID 10693087, PMID 10720604, PMID 11319655, PMID 11926784, PMID 12589096, PMID 15353531, PMID 15793206, PMID 16291063, PMID 16389125, PMID 16758177, PMID 17277315, PMID 18612117, PMID 18990064, PMID 19383872, PMID 20032779, PMID 20332511, PMID 20336198, PMID 20655123, PMID 20818193, PMID 20876709, PMID 21540423, PMID 21636159, PMID 22417277, PMID 22883509, PMID 23159553, PMID 23222938, PMID 23613782, PMID 24657294, PMID 24822048, PMID 24843743, PMID 25329391, PMID 25493265, PMID 25538310, PMID 25580754, PMID 25705296, PMID 25765355, PMID 25860638, PMID 25897193, PMID 26340966, PMID 26578192, PMID 27076876, PMID 27926890

NIH funding

2015 (3), U24DK122927 (3), 2018 (2), 2019 (2), 2023 (2), K23DK131261 (2), 2008 (1), 2016 (1), K23DK081021 (1), K23HL143178 (1), P30DK017047 (1), P30DK020572 (1), P30DK111022 (1), R01DK125835 (1), R01DK132569 (1)