Leg Ulcer: Clinical Trials

709 completed, 260 unknown, 147 recruiting, 135 terminated. 765 Not applicable, 185 Phase 2, 116 Phase 1, 99 Phase 3, 82 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	765	Completed 366, Unknown 137, Recruiting 89, Terminated 70, Not yet recruiting 44, Active not recruiting 25, Withdrawn 25, Enrolling by invitation 6, Suspended 3
Phase 2	185	Completed 101, Unknown 34, Terminated 21, Recruiting 11, Not yet recruiting 9, Active not recruiting 4, Withdrawn 4, Suspended 1
Phase 1	116	Completed 57, Unknown 27, Terminated 11, Not yet recruiting 7, Active not recruiting 5, Recruiting 5, Withdrawn 3, Suspended 1
Phase 3	99	Completed 49, Terminated 21, Unknown 12, Recruiting 8, Active not recruiting 3, Not yet recruiting 3, Withdrawn 3
Phase 4	82	Completed 39, Unknown 12, Recruiting 11, Terminated 11, Withdrawn 6, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1
Early Phase 1	14	Unknown 6, Completed 5, Not yet recruiting 1, Recruiting 1, Withdrawn 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
On the Move: Center and Home-Based Exercise to Enhance Mobility in Diabetic Foot Ulcer Recovery 12-week exercise regimen, 12-week standard of care - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	University of Maryland, Baltimore	60	2027-06-01	2026-10-07
Clinical Performance of ComBatic™ Antimicrobial Wound Care Products in Hard-to-Heal Wounds Irrigation Solution for wounds, Hydrogel for wound care - Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer), Chronic Wound Care	Phase 2	Not yet recruiting	University of Calgary	96	2027-01-01	2026-10-14
Subcutaneous Dexpanthenol Administration and Wound Epithelialization Dexpanthenol, Standard Wound Care - Chronic Wounds, Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Dilara CANBAY OZDEMIR	40	2026-12-02	2026-10-22
Clinical Efficacy of Modified Simiao Yongan Decoction and Endovascular Therapy for Diabetic Foot Ulcers Modified Simiao Yongan Decoction, Endovascular Therapy and Standard Care - Diabetic Foot Ulcer, Damp-Heat Toxins Accumulation Syndrome	Not applicable	Not yet recruiting	Chengdu University of Traditional Chinese Medicine	120	2026-12-01	2026-09-08
18F-FDG PET/CT for Diagnosis of Diabetic Foot Osteomyelitis 18F-FDG PET/CT - Diabetic Foot Infections		Not yet recruiting	Jewish General Hospital	150	2026-11-01	2026-09-18
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery Diabetic Foot Ulcer, Wound Healing		Recruiting	Universidade Sao Francisco	40	2026-10-21	2026-10-22
Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer	Phase 4	Not yet recruiting	First Affiliated Hospital of Wenzhou Medical University	180	2026-10-20	2026-09-18
a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers Standard of Care, BIOxHEAL (human amniotic membrane allograft) - Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft	Phase 3	Recruiting	Applied Biologics, LLC	253	2026-10-08	2026-10-16
The GORE® VIABAHN® FORTEGRA Venous Stent Post-Approval Study GORE® VIABAHN® FORTEGRA Venous Stent - Venous Thromboses, Venous Disease	Not applicable	Not yet recruiting	W.L.Gore & Associates	150	2026-10-07	2026-08-12
LUT017 Gel for Venous Leg Ulcers and Chronic Non-Healing Skin Wounds in Adults LUT017 gel - Venous Leg Ulcer, Chronic Non-Healing Cutaneous Wounds	Phase 1	Not yet recruiting	Antoni Ribas	18	2026-10-02	2026-05-29
Activity Reduction vs Advice for Plantar Hotspots in Diabetes Individualized Objectively Monitored Activity Reduction, Standard Activity-Reduction Advice - Diabetic Foot, Diabetic Peripheral Neuropathy	Not applicable	Not yet recruiting	Shifa International Hospital	100	2026-10-01	2026-09-25
Placental Cells for Diabetic Foot Ulcers Placenta Stem Cells - Diabetic Foot Ulcer	Phase 1	Not yet recruiting	Wake Forest University Health Sciences	12	2026-10-01	2026-07-07
Dose-Response Structured Calf Muscle Pump Activation Strategies Versus Unsupervised Home Walks Dose-Response Structured CMP Activation, Active Control - Venous Ulcer of Leg	Not applicable	Not yet recruiting	MTI University	80	2026-10-01	2026-08-13
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System in the Healing of Diabetic Foot Ulcers Syntrfuge Microfragmented Fat, Standard of Care - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	62	2026-09-30	2026-08-21
Nutritional Status in Adults With Diabetic Foot Ulcers Protein supplementation and nutrition education - Diabetic Foot Ulcers (DFU), Nutrition Assessment		Not yet recruiting	Hvidovre University Hospital	30	2026-09-21	2026-09-18
Effect of Digital-Supported Foot Care Education in Individuals With Type 2 Diabetes Digital-Supported Foot Care Education - Type 2 Diabetes Mellitus (T2DM)	Not applicable	Not yet recruiting	Siirt University	90	2026-09-20	2026-09-10
Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds Biodynamik XT3 - Diabetic Foot Ulcer, Chronic Ulcers of the Lower Limb	Not applicable	Recruiting	Biodynamik, Inc	100	2026-09-15	2026-09-14
DiaFootCare to Promote Self-Care of Diabetic Foot Ulcers in Oman DiaFootCare Mobile Application, Usual Diabetic Foot Care - Diabetic Foot Ulcer (DFU), Diabetes Mellitus	Not applicable	Not yet recruiting	Oman Ministry of Health	139	2026-09-13	2026-09-29
The ProActive Study- Integrating a Proactive and Palliative Care Approach to Diabetic Ulcer Care Diabetic Foot Ulcer (DFU), Palliative Care		Not yet recruiting	Ulla Riis Madsen	484	2026-09-01	2026-08-24
Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Diabetic Foot Ulcers PRFM, Standard of Care (SoC) - Diabetic Foot Ulcer (DFU), Ulcer	Phase 1 / Phase 2	Not yet recruiting	Tiger Biosciences, LLC.	55	2026-09-01	2026-09-25

Showing 20 of 1437. Sign in to see all of them.

Narrower conditions

Diabetic Foot (1030)  ·  Varicose Ulcer (366)  ·  Diabetes Mellitus (245)  ·  Foot Ulcer (171)  ·  Ulcer (93)  ·  Wounds and Injuries (82)  ·  Pressure Ulcer (71)  ·  Diabetic Neuropathies (50)  ·  Diabetes Complications (49)  ·  Diabetes Mellitus, Type 2 (48)  ·  Peripheral Arterial Disease (34)  ·  Chronic Limb-Threatening Ischemia (28)  ·  Venous Insufficiency (26)  ·  Skin Ulcer (25)

Broader conditions

Skin and Connective Tissue Diseases (1437)  ·  Skin Diseases (1431)  ·  Skin Ulcer (1412)  ·  Cardiovascular Diseases (1330)  ·  Vascular Diseases (1327)  ·  Endocrine System Diseases (1061)  ·  Diabetic Angiopathies (1019)  ·  Diabetes Complications (982)  ·  Diabetic Neuropathies (981)  ·  Foot Ulcer (920)  ·  Diabetes Mellitus (821)  ·  Varicose Veins (351)  ·  Nutritional and Metabolic Diseases (291)  ·  Metabolic Diseases (282)

Interventions

Standard of Care (110)  ·  Bandages (19)  ·  Sodium Chloride (12)  ·  Negative-Pressure Wound Therapy (11)  ·  Debridement (10)  ·  Low-Level Light Therapy (10)  ·  Control Groups (9)  ·  Educational Status (9)  ·  Collagenases (7)  ·  Saline Solution (7)  ·  Becaplermin (6)  ·  Exercise (6)  ·  Extracorporeal Shockwave Therapy (6)  ·  Gels (6)  ·  Hydrogels (6)

Sponsors

ConvaTec Inc. (17)  ·  Healthpoint (17)  ·  Integra LifeSciences Corporation (17)  ·  University of Texas Southwestern Medical Center (17)  ·  Molnlycke Health Care AB (14)  ·  Organogenesis (14)  ·  Universidad Complutense de Madrid (14)  ·  Laboratoires URGO (12)  ·  Smith & Nephew, Inc. (12)  ·  Cairo University (11)  ·  MiMedx Group, Inc. (11)  ·  Anterogen Co., Ltd. (10)  ·  Centre Hospitalier Universitaire de Nīmes (9)  ·  University of Michigan (9)  ·  Assiut University (8)

Countries

United States (508)  ·  United Kingdom (103)  ·  France (93)  ·  Germany (65)  ·  Canada (58)  ·  Spain (53)  ·  China (51)  ·  Turkey (Türkiye) (51)  ·  Italy (50)  ·  Denmark (38)  ·  Egypt (38)  ·  Sweden (37)  ·  Poland (35)  ·  Taiwan (27)  ·  Israel (26)

Top investigators

Herbert B Slade, MD (12)  ·  William Marston, MD (8)  ·  David Armstrong, DPM, MD, PhD (7)  ·  Lawrence Lavery, DPM MPH (5)  ·  Angelina Ferguson, DNP (4)  ·  Chandan K Sen, PhD (4)  ·  Lawrence Lavery, DPM (4)  ·  Prema Dhanraj, MS, MCh (4)  ·  Robert Kirsner, MD (4)  ·  Thomas E Serena, MD (4)  ·  Thomas Serena, MD (4)  ·  Tommy Lee, MSHS (4)  ·  Windy Cole, DPM (4)  ·  Alisha Oropallo, MD (3)

Results publications

PMID 28614678, PMID 16291066, PMID 23958264, PMID 24767584, PMID 26738255, PMID 27269974, PMID 29037354, PMID 34187716, PMID 35534614, PMID 10693087, PMID 10720604, PMID 11319655, PMID 11926784, PMID 12589096, PMID 15353531, PMID 15793206, PMID 16291063, PMID 16389125, PMID 16758177, PMID 17277315, PMID 18612117, PMID 18990064, PMID 19383872, PMID 20032779, PMID 20332511, PMID 20336198, PMID 20655123, PMID 20818193, PMID 20876709, PMID 21540423, PMID 21636159, PMID 22417277, PMID 22883509, PMID 23159553, PMID 23222938, PMID 23613782, PMID 24657294, PMID 24822048, PMID 24843743, PMID 25329391, PMID 25493265, PMID 25538310, PMID 25580754, PMID 25705296, PMID 25765355, PMID 25860638, PMID 25897193, PMID 26025146, PMID 26340966, PMID 26578192

NIH funding

2015 (4), 2023 (3), U24DK122927 (3), 2014 (2), 2018 (2), 2019 (2), K23DK131261 (2), 2008 (1), 2016 (1), K23DK081021 (1), K23HL143178 (1), N01AR092238 (1), P30DK017047 (1), P30DK020572 (1), P30DK111022 (1)