38 completed, 18 terminated, 10 unknown, 5 recruiting. 76 Phase 3, 14 Phase 2.
Follow Foot Ulcer: new trials by email Literature Review of Foot Ulcer trials Research Report on Foot Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers Standard of Care, BIOxHEAL (human amniotic membrane allograft) - Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft | Phase 3 | Recruiting | Applied Biologics, LLC | 253 | 2026-10-08 | 2026-10-16 |
| Effect of Semaglutide on Healing of Foot Ulcers in Type 2 Diabetes Patients Semaglutide, 1.34 mg/mL, Placebo - Foot Ulcer Due to Type 2 Diabetes Mellitus | Phase 3 | Recruiting | Ole Lander Svendsen | 52 | 2026-04-24 | 2026-05-12 |
| Phase IIb and III Safety and Efficacy Study Chlorin E6 Gel Photodynamic Therapy for Diabetic Foot Ulcers: Chlorin E6 Gel - Diabetic Foot Ulcer (DFU) | Phase 3 | Recruiting | United Medical and Dental College | 300 | 2026-04-02 | 2026-04-07 |
| Efficacy of Carbonlife Amniotic Tissue Product in the Treatment of Chronic Wounds Amniotic Tissue Allograft - Chronic Wounds, Venous Leg Ulcers (VLUs) | Phase 3 | Not yet recruiting | Bardia Anvar | 600 | 2026-01-01 | 2025-11-06 |
| The Effects of Bromelain Supplement in Patients with Diabetic Foot Ulcers Bromelain, Placebo - Diabetic Foot Ulcer (DFU) | Phase 3 | Not yet recruiting | Dr Azita Hekmatdoost | 70 | 2025-03-01 | 2025-01-22 |
| The Prospective, Double-blind, Multicenter, Placebo-controlled, Randomized, Comparative Clinical Trial Neovasculgen®, Placebo - Ulcer Foot, Mellitus Diabetes | Phase 3 | Recruiting | JSC NextGen | 144 | 2025-02-11 | 2026-02-05 |
| Evaluate the Efficacy and Safety of Xianglei Tangzu Gao for the Treatment of Wagner Grade II Diabetic Foot Ulcers Xianglei Tangzu Gao, Vehicle Cream - Diabetic Foot Ulcer | Phase 2 / Phase 3 | Active not recruiting | Oneness Biotech Co., Ltd. | 120 | 2024-08-16 | 2026-06-12 |
| SkinTE® for the Treatment of Wagner 1 Diabetic Foot Ulcers (COVER DFUS II) SkinTE, Control - Diabetic Foot | Phase 3 | Active not recruiting | PolarityTE | 100 | 2024-02-22 | 2025-07-11 |
| A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer ENERGI-F703 GEL, ENERGI-F703 matched vehicle - Diabetic Foot Ulcer, Foot Ulcer | Phase 3 | Recruiting | Energenesis Biomedical Co., Ltd. | 230 | 2023-05-30 | 2025-10-02 |
| Adipose Derived Regenerative Cells In the Treatment of Diabetic Foot Ulcers ADRCs, standard care, Placebo - Diabetic Foot Ulcer | Phase 3 | Unknown | Paracrine, INC. | 290 | 2023-02-28 | 2022-09-28 |
| Immunonutrition for Diabetic Foot Ulcers Lovaza, L-Arginine Powder, Vitamin C - Diabetes Mellitus, Diabetic Peripheral Neuropathy | Phase 2 / Phase 3 | Terminated | Prisma Health-Midlands | 1 | 2023-02-08 | 2024-12-27 |
| Restoring Tissue and Evaluating Novel Treatments for Efficacy in Wounds Lavior Diabetic Wound Gel, Smith & Nephew Solosite Gel Hydrogel Wound Dressing - Diabetic Foot Ulcer | Phase 2 / Phase 3 | Completed | Lavior Pharma Inc. | 75 | 2022-12-15 | 2024-10-08 |
| Multi-Center, Prospective, Randomized Controlled Trial Evaluating SkinTE® in the Treatment of Wagner 2 DFUs SkinTE, Control - Diabetic Foot | Phase 3 | Terminated | PolarityTE | 42 | 2022-04-28 | 2024-02-26 |
| Umbilical Cord Blood Mononuclear Cell Gel in the Treatment of Refractory Diabetic Foot Ulcer Umbilical cord blood mononuclear cell gel（MNC）, The platelet rich plasma（PRP） - Diabetic Foot Ulcer | Phase 3 | Unknown | Peking University Third Hospital | 40 | 2021-03-30 | 2022-09-29 |
| Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Wagner Grade 2 Foot Ulcers. ALLO-ASC-DFU, Vehicle Sheet - Diabetic Foot Ulcer | Phase 3 | Completed | Anterogen Co., Ltd. | 104 | 2020-07-14 | 2025-09-22 |
| The Effect of Platelet-Rich Plasma-Fibrin Glue in Combination With Vitamin E and C for Treatment of Non-healing Diabetic Foot Ulcers PRP-Fibrin Glue, Vitamin E and C, Placebo - Diabetic Foot Ulcers, Diabetic Wound | Phase 2 / Phase 3 | Unknown | Mashhad University of Medical Sciences | 24 | 2019-08-28 | 2020-03-20 |
| Phase 3 Study to Evaluate the Safety and Efficacy of Galnobax® in Treating Diabetic Foot Ulcers Esmolol Hydrochloride, Only Standard of Care, Vehicle Gel - Diabetic Foot Ulcer | Phase 3 | Completed | Novalead Pharma Private Limited | 176 | 2018-12-26 | 2023-09-22 |
| A Study of Granexin Gel in the Treatment of Diabetic Foot Ulcer Granexin gel, Vehicle gel - Diabetic Foot Ulcers | Phase 3 | Terminated | Xequel Bio, Inc. | 124 | 2018-11-21 | 2020-05-29 |
| Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing Becaplermin, Promagran Dressing, Placebo Dressing - Venous Ulcer, Foot Ulcer, Diabetic | Phase 3 | Unknown | McMaster University | 80 | 2018-08-01 | 2018-04-09 |
| Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers. ALLO-ASC-DFU, Vehicle sheet - Diabetic Foot Ulcer | Phase 3 | Completed | Anterogen Co., Ltd. | 150 | 2018-06-27 | 2023-08-25 |
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Diabetic Foot (73) · Diabetes Mellitus (19) · Ulcer (10) · Wounds and Injuries (5) · Diabetes Complications (3) · Infections (3) · Arterial Occlusive Diseases (2) · Chronic Limb-Threatening Ischemia (2) · Diabetic Neuropathies (2) · Ischemia (2) · Osteomyelitis (2) · Peripheral Vascular Diseases (2) · Abscess (1) · Bacterial Infections (1)
Skin Diseases (76) · Skin and Connective Tissue Diseases (76) · Endocrine System Diseases (75) · Leg Ulcer (75) · Skin Ulcer (75) · Cardiovascular Diseases (74) · Vascular Diseases (74) · Diabetic Angiopathies (72) · Diabetic Neuropathies (71) · Diabetes Complications (70) · Diabetes Mellitus (56) · Glucose Metabolism Disorders (19) · Metabolic Diseases (19) · Nutritional and Metabolic Diseases (19)
Standard of Care (8) · Becaplermin (2) · Dalteparin (2) · Debridement (2) · Ertapenem (2) · Ofloxacin (2) · Piperacillin (2) · Sodium Chloride (2) · Tazobactam (2) · Urokinase-Type Plasminogen Activator (2) · aclerastide (2) · bemiparin (2) · dexpanthenol (2) · pexiganan (2) · salicylhydroxamic acid (2)
Integra LifeSciences Corporation (3) · Organogenesis (3) · Abeona Therapeutics, Inc (2) · Anterogen Co., Ltd. (2) · European Egyptian Pharmaceutical Industries (2) · Innocoll (2) · Olympus Biotech Corporation (2) · Oneness Biotech Co., Ltd. (2) · Pfizer (2) · PolarityTE (2) · SANUWAVE, Inc. (2) · Abbott Nutrition (1) · Adocia (1) · ApoPharma (1) · Applied Biologics, LLC (1)
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Jean-Charles Kerihuel, MD (2) · Nigel Jones (2) · Nikolai Sopko, MD, PhD (2) · Paul Litka, MD (2) · Roslyn R Isseroff, M.D. (2) · Adam Landsman, DPM, PhD (1) · Alan Dunton, MD (1) · Alberto Restrepo, M.D. (1) · Anne Voss, PhD, RD (1) · Arturo Orduz, MD (1) · Arun Bal, MD (1) · Ashu Rastogi, MD (1) · BaekKyu Kim, MD. Ph D (1)
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