20 completed, 4 recruiting, 4 unknown, 3 not yet recruiting. 18 Not applicable, 3 Phase 2, 2 Phase 3, 1 Phase 1, 1 Phase 4.
Follow Extreme Prematurity: new trials by email Literature Review of Extreme Prematurity trials Research Report on Extreme Prematurity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants High-energy group, Standard-energy group - Extreme Prematurity, Enteral Nutrition | Phase 1 / Phase 2 | Recruiting | University of Alabama at Birmingham | 150 | 2026-09-21 | 2026-09-24 |
| Ventilator Pressure and Optimization of Compliance and Hemodynamics Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP - Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia | Not applicable | Recruiting | University of Alabama at Birmingham | 24 | 2026-08-01 | 2026-05-11 |
| Single-dose Prophylactic INdomethacin in Extremely Preterm Infants Indomethacin, Placebo - Extreme Prematurity, Intraventricular Hemorrhage | Phase 2 | Not yet recruiting | University of British Columbia | 500 | 2025-11-01 | 2025-09-03 |
| Folic Acid Supplementation to Reduce Anemia in Extremely Preterm Infants Folic acid - Extreme Prematurity, Anemia of Prematurity | Not applicable | Not yet recruiting | University of Calgary | 90 | 2024-06-01 | 2024-05-09 |
| Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis Dopamine, Norepinephrine - Late-Onset Neonatal Sepsis, Extreme Prematurity | Recruiting | Mount Sinai Hospital, Canada | 550 | 2023-02-06 | 2026-10-16 | |
| The Pilot Experimental Study of the Neuroprotective Effects of Exosomes in Extremely Low Birth Weight Infants Exosomes derived from mesenchymal stromal cells (MSCs) - Premature Birth, Extreme Prematurity | Not applicable | Not yet recruiting | Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare | 10 | 2022-10-05 | 2022-09-28 |
| Effectiveness of Home Based Early Intervention of Extremely Premature Infant by Parent Home Based Early Intervention by Parent - Preterm, Extreme Prematurity | Not applicable | Unknown | Samsung Medical Center | 110 | 2022-06-02 | 2022-06-08 |
| Improve the Survival Without Morbidity of Extremely Preterm Infants (PREMEX) Premex Protocol - Newborn, Extreme Prematurity | Not applicable | Active not recruiting | Assistance Publique - Hôpitaux de Paris | 2377 | 2022-06-01 | 2025-11-20 |
| PeriviAble DeLiveries: ALIgning PArental aNd PhysiCian PrioritiEs (ALLIANCE) Mixed Methods study - Periviable Infants, Extreme Prematurity | Unknown | Manchester University NHS Foundation Trust | 340 | 2022-05-31 | 2023-08-31 | |
| RCT: The Effect of Held Position During Kangaroo Care on Physiological Parameters of Premature Infants Held Position - Extreme Prematurity, Extremely Low Birth Weight | Not applicable | Completed | University College Cork | 20 | 2022-05-16 | 2023-01-19 |
| Relationship Between Fungal Colonization and Severe Bronchopulmonary Dysplasia biological - Bronchopulmonary Dysplasia, Extreme Prematurity | Completed | Centre Hospitalier Sud Francilien | 153 | 2022-03-21 | 2024-11-26 | |
| Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration - IVH- Intraventricular Hemorrhage, Extreme Prematurity | Not applicable | Active not recruiting | Sharp HealthCare | 140 | 2021-11-17 | 2026-10-15 |
| SafeBoosC III Two-year Follow-up Treatment as usual + cerebral oximetry monitoring the first 72 hours of life - Deficits, Neurologic, Extreme Prematurity | Completed | Gorm Greisen | 1601 | 2021-09-23 | 2024-11-07 | |
| LISA in the Delivery Room for Extremely Preterm Infants LISA - Extreme Prematurity, Respiratory Distress Syndrome | Not applicable | Completed | University of Texas Southwestern Medical Center | 60 | 2021-06-22 | 2026-10-09 |
| Early Intervention Based on Neonatal Crawling in Very Premature Infants at Risk For Neurodevelopmental Disorder Crawling stimulation with a mini-skateboard (i.e. the crawliskate) - Prematurity, Extreme Prematurity | Not applicable | Recruiting | Marianne Barbu-Roth | 50 | 2021-03-29 | 2023-09-13 |
| Time to Accurate Heart Rate on Neonatal Outcomes iRes Warmer with ResusView, iRes Warmer without ResusView - Premature Infant, Extremely Low Birth Weight | Not applicable | Completed | Sharp HealthCare | 42 | 2021-02-01 | 2024-01-10 |
| Osteopathic Manipulative Medicine to Reduce Developmental Delays Osteopathic Manipulative Medicine - Extreme Prematurity, Neurodevelopmental Abnormality | Not applicable | Completed | University of Rochester | 150 | 2021-01-05 | 2023-08-14 |
| Protecting Brains and Saving Futures - the PBSF Protocol Brain Injuries, Congenital Heart Disease | Unknown | Protecting Brains Saving Futures | 2268 | 2021-01-01 | 2020-11-16 | |
| Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen Acetaminophen, NACL 0.9% - Patency of the Ductus Arteriosus, Acetaminophen | Phase 2 / Phase 3 | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 804 | 2020-10-29 | 2026-03-16 |
| Extremely Premature Births During the Peak of the COVID-19 Pandemic: an International Study of the Active SafeBoosC III Departments Extreme Prematurity, Covid19 | Completed | Copenhagen University Hospital, Rigshospitalet | 885 | 2020-08-21 | 2020-10-08 |
Showing 20 of 33. Sign in to see all of them.
Premature Birth (13) · Brain Injuries (4) · Bronchopulmonary Dysplasia (3) · Ductus Arteriosus, Patent (2) · Hypoxia-Ischemia, Brain (2) · Learning Disabilities (2) · Neonatal Sepsis (2) · Perinatal Death (2) · Respiratory Distress Syndrome (2) · Acute Lung Injury (1) · Anemia (1) · Asphyxia Neonatorum (1) · COVID-19 (1) · Central Nervous System Infections (1) · Cerebral Palsy (1)
Female Urogenital Diseases and Pregnancy Complications (14) · Pregnancy Complications (14) · Urogenital Diseases (14) · Obstetric Labor Complications (13) · Obstetric Labor, Premature (13) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Pathological Conditions, Signs and Symptoms (9) · Infant, Newborn, Diseases (7) · Respiratory Tract Diseases (7) · Signs and Symptoms (7) · Lung Diseases (6) · Nervous System Diseases (6) · Brain Diseases (5) · Cardiovascular Diseases (5) · Central Nervous System Diseases (5)
Acetaminophen (2) · Indomethacin (2) · Saline Solution (2) · Sodium Chloride (2) · Standard of Care (2) · Ampicillin (1) · Biological Products (1) · Dopamine (1) · Eosinophil Peroxidase (1) · Erythropoietin (1) · Folic Acid (1) · Gentamicins (1) · Ibuprofen (1) · Interviews as Topic (1) · Massage (1)
Sharp HealthCare (2) · University of Alabama at Birmingham (2) · Assistance Publique - Hôpitaux de Paris (1) · Baylor College of Medicine (1) · Centre Hospitalier Sud Francilien (1) · Christiana Care Health Services (1) · Copenhagen University Hospital, Rigshospitalet (1) · Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare (1) · Gorm Greisen (1) · Guilherme Sant'Anna, MD (1) · IWK Health Centre (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Manchester University NHS Foundation Trust (1) · Marianne Barbu-Roth (1) · Medical University of Vienna (1)
United States (15) · Canada (6) · France (4) · Denmark (3) · Ireland (3) · Australia (2) · Austria (2) · Germany (2) · Italy (2) · Sweden (2) · Belgium (1) · Brazil (1) · Estonia (1) · Finland (1) · Hungary (1)
Anup Katheria, MD (2) · Amish Jain, MBBS, MRCPCH, PhD (1) · Amish Jain, MBBS, PhD (1) · Anna Kirtbaya, PhD, MD (1) · Ariel A. Salas, MD, MSPH (1) · Axel Franz, MD (1) · Belal Alshaikh, MD, MSc (1) · Christopher J. Rhee, MD (1) · Colm P Travers, MD (1) · Dana McCarty, DPT (1) · Denis Silachev, PhD, MD (1) · Dmitriy Degtyarev, PhD, MD (1) · Ekaterina Balashova, PhD, MD (1) · GianLuca Lista, MD (1)
PMID 10835058, PMID 10945393, PMID 16763218, PMID 19364558, PMID 25872563, PMID 27057344, PMID 27164830, PMID 27745747, PMID 27837749, PMID 27893064, PMID 28821985, PMID 29739389, PMID 30912836, PMID 31828052, PMID 31940698, PMID 32488672, PMID 32804205, PMID 33113526, PMID 33322234, PMID 33952559, PMID 34117080, PMID 34322460, PMID 34324880, PMID 34453917, PMID 34630028, PMID 34715091, PMID 34845352, PMID 35020756, PMID 35338252, PMID 35606829, PMID 35725917, PMID 35853728, PMID 36503480, PMID 36580332, PMID 37561461, PMID 37790304, PMID 37805539, PMID 37926336, PMID 37978159, PMID 38195921, PMID 38195922, PMID 39164062, PMID 39390245, PMID 39578300, PMID 39948605, PMID 40186001, PMID 40678377, PMID 40690234, PMID 40816312, PMID 40889095
2019 (1), K23NS091382 (1), KL2TR002490 (1), R01HD097578 (1), R03HD105224 (1), R34HL183268 (1), U01HD072906 (1), U01NS077953 (1)