16 completed, 2 terminated, 2 unknown. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Completed 16, Terminated 2, Unknown 2 |
Follow Euglenozoa Infections: new trials by email Literature Review of Euglenozoa Infections trials Research Report on Euglenozoa Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC Sacubitril/valsartan, Enalapril - Chagas Disease, Heart Failure | Phase 4 | Completed | Novartis Pharmaceuticals | 922 | 2019-12-10 | 2026-05-11 |
| Single Dose Liposomal Amphotericin B for Visceral Leishmaniasis AMBISOME - Visceral Leishmaniasis | Phase 4 | Unknown | Banaras Hindu University | 1300 | 2014-06-01 | 2014-01-22 |
| Safety and Effectiveness of Short-course AmBisome in the Treatment of PKDL in Bangladesh AmBisome - Post-kala-azar Dermal Leishmaniasis | Phase 4 | Completed | Medecins Sans Frontieres, Netherlands | 280 | 2014-04-08 | 2017-10-17 |
| Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease Implantable Cardiac Monitor, Standard of Care - Chagas Disease, Heart Diseases | Phase 4 | Terminated | Medtronic Cardiac Rhythm and Heart Failure | 12 | 2013-07-01 | 2016-10-12 |
| A Study to Explore Association of Treatment Regimens for Visceral Leishmaniasis, Host Immunological, Genetical and Nutrition Factors With Post-kala-azar Dermal Leishmaniasis (PKDL) Mitefosine - Post-kala-azar Dermal Leishmaniasis | Phase 4 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 36 | 2013-01-01 | 2014-11-05 |
| Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease Benznidazole - Chagas Disease | Phase 4 | Completed | Barcelona Centre for International Health Research | 52 | 2012-12-01 | 2015-05-27 |
| Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS) Aspirin - Chagas Disease With Heart Failure | Phase 4 | Unknown | Federal University of Bahia | 500 | 2012-07-01 | 2023-03-03 |
| Pharmacokinetics of Miltefosine in Children and Adults Miltefosine - Cutaneous Leishmaniasis | Phase 4 | Completed | Centro Internacional de Entrenamiento e Investigaciones Médicas | 60 | 2011-10-01 | 2016-08-22 |
| Population Pharmacokinetics Study of Benznidazole in Children With Chagas'Disease Benznidazole 12,5mg or 100mg - Chagas' Disease | Phase 4 | Completed | Drugs for Neglected Diseases | 80 | 2011-05-01 | 2018-06-25 |
| Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease Benznidazole - Chagas Disease | Phase 4 | Completed | Drugs for Neglected Diseases | 220 | 2011-04-01 | 2018-06-25 |
| Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Brazil Antimoniate of N-methylglucamine, amphotericin B deoxycholate, Liposomal amphotericin B - Visceral Leishmaniasis | Phase 4 | Terminated | University of Brasilia | 378 | 2011-02-01 | 2017-09-05 |
| Outcomes of an Anticoagulation Clinic in an University Hospital Anticoagulation clinic, Standard anticoagulation care - Cardiopathy, Chagas Disease | Phase 4 | Completed | Federal University of Minas Gerais | 280 | 2009-11-01 | 2011-10-25 |
| Efficacy of Radio-frequency Induced Heat (RFH)Therapy in Treatment of Cutaneous Leishmaniasis in India RFH therapy, Sodium stibogluconate - Cutaneous Leishmaniasis | Phase 4 | Completed | Sarder Patel Medical College | 100 | 2009-08-01 | 2012-09-03 |
| Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase Nifurtimox-Eflronithine Combination Treatment (NECT) - Human African Trypanosomiasis | Phase 4 | Completed | Drugs for Neglected Diseases | 630 | 2009-04-01 | 2013-05-31 |
| Low-dose Pentavalent Antimony Treatment of Cutaneous Leishmaniasis in Old Age Patients Meglumine antimoniate - Localized Cutaneous Leishmaniasis | Phase 4 | Completed | University of Brasilia | 13 | 2008-08-01 | 2010-10-08 |
| Expand Access/Assess Safety and Efficacy of Paromomycin IM Injection for the Treatment of Visceral Leishmaniasis Paromomycin sulfate - Visceral Leishmaniasis | Phase 4 | Completed | PATH | 2000 | 2007-10-01 | 2014-10-03 |
| Amphotericin B to Treat Visceral Leishmaniasis in Brazilian Children Meglumine antimoniate, Amphotericin B-deoxycholate - Visceral Leishmaniasis | Phase 4 | Completed | University of Brasilia | 101 | 2007-10-01 | 2017-09-05 |
| Exercise Training in Chagas Cardiomyopathy Exercise training - Chagas Disease, Cardiomyopathy | Phase 4 | Completed | Federal University of Minas Gerais | 37 | 2007-03-01 | 2015-08-13 |
| Safety and Efficacy of Low-Dose Pentavalent Antimony for Treatment of Cutaneous Leishmaniasis Meglumine antimoniate - Cutaneous Leishmaniasis | Phase 4 | Completed | University of Brasilia | 280 | 2006-02-01 | 2009-01-22 |
| A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy RASi plus carvedilol - Chagas Cardiomyopathy, Heart Failure | Phase 4 | Completed | Federal University of Minas Gerais | 42 | 2003-05-01 | 2015-08-13 |
Chagas Disease (8) · Leishmaniasis, Visceral (5) · Leishmaniasis, Cutaneous (4) · Heart Failure (3) · Chagas Cardiomyopathy (2) · Heart Diseases (2) · Leishmaniasis (2) · Cardiomyopathies (1) · Cardiomyopathy, Dilated (1) · Dementia (1) · Disease (1) · Hemorrhage (1) · Hyperthermia (1) · Stroke (1) · Thrombosis (1)
Infections (20) · Parasitic Diseases (20) · Protozoan Infections (20) · Vector Borne Diseases (20) · Trypanosomiasis (10) · Leishmaniasis (8) · Cardiovascular Diseases (6) · Skin Diseases (5) · Skin Diseases, Infectious (5) · Skin Diseases, Parasitic (5) · Skin and Connective Tissue Diseases (5) · Heart Diseases (4) · Pathological Conditions, Signs and Symptoms (3) · Pathologic Processes (2)
Meglumine Antimoniate (4) · liposomal amphotericin B (3) · Amphotericin B (2) · amphotericin B, deoxycholate drug combination (2) · benzonidazole (2) · Antimony Sodium Gluconate (1) · Aspirin (1) · Carvedilol (1) · Clinical Trials as Topic (1) · Control Groups (1) · Diathermy (1) · Double-Blind Method (1) · Eflornithine (1) · Enalapril (1) · Exercise (1)
University of Brasilia (4) · Drugs for Neglected Diseases (3) · Federal University of Minas Gerais (3) · Banaras Hindu University (1) · Barcelona Centre for International Health Research (1) · Centro Internacional de Entrenamiento e Investigaciones Médicas (1) · Federal University of Bahia (1) · International Centre for Diarrhoeal Disease Research, Bangladesh (1) · Medecins Sans Frontieres, Netherlands (1) · Medtronic Cardiac Rhythm and Heart Failure (1) · Novartis Pharmaceuticals (1) · PATH (1) · Sarder Patel Medical College (1)
Brazil (9) · Argentina (3) · Colombia (3) · India (3) · Bangladesh (1) · Bolivia (1) · Mexico (1) · Republic of the Congo (1) · Spain (1)
Antonio L Ribeiro, MD, PhD (2) · Amrendra K Aditya, MD (1) · Ana LT Rabello, MD PhD (1) · Andrea L de Carvalho, MD (1) · C P Thakur, MD (1) · Carlos HN Costa, MD PhD (1) · Claudio Muratore, MD (1) · Daniel D Ribeiro, Physician (1) · Devendra Nath, MD (1) · Diego Venagas, MD (1) · Dinesh Mondal, MB; MD; PhD (1) · Dorcas L Costa, MD PhD (1) · Fabiana P Alves, MD PhD (1)
PMID 17383291, PMID 20412275, PMID 20675669, PMID 23209861, PMID 23232458, PMID 25098373, PMID 25824212, PMID 27956421, PMID 28327804, PMID 28379954, PMID 28662034, PMID 29351667, PMID 30509941, PMID 31986140, PMID 34748572, PMID 37256863, PMID 39111953, PMID 41335448
R01NS064905 (1)