43 completed, 7 recruiting, 7 terminated, 3 unknown. 13 Phase 3, 10 Not applicable, 9 Phase 2, 6 Phase 1, 5 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 13 |
| Not applicable | 10 | Completed 9, Unknown 1 |
| Phase 2 | 9 | Completed 6, Terminated 3 |
| Phase 1 | 6 | Completed 5, Terminated 1 |
| Phase 4 | 5 | Completed 3, Terminated 1, Unknown 1 |
Follow Leishmaniasis, Visceral: new trials by email Literature Review of Leishmaniasis, Visceral trials Research Report on Leishmaniasis, Visceral
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ex Vivo Immunogenicity Screening of Vaccine Candidate Antigen Combinations in Ethiopian Patients With Leishmaniasis Leishmaniasis, Cutaneous, Leishmaniasis | Recruiting | Institute of Tropical Medicine, Belgium | 90 | 2026-05-26 | 2026-08-24 | |
| Recurrent Visceral Leishmaniasis in HIV Co-Infection Hiv, Visceral Leishmaniasis | Recruiting | Institute of Tropical Medicine, Belgium | 20 | 2025-10-21 | 2026-03-23 | |
| Human Bioequivalence Study of Liposomal Amphotericin B for Injection Test product (Liposomal amphotericin B for injection, Sichuan Huiyu Pharmaceutical Co., Ltd.), Reference product (AmBisome®, Astellas Pharma US Inc.) - Invasive Fungal Infections, Neutropenic Fever | Not applicable | Completed | Sichuan Huiyu Pharmaceutical Co., Ltd | 58 | 2025-05-25 | 2026-05-27 |
| Human Bioequivalence Study of Amphotericin B Liposome for Injection Amphotericin B Liposome for Injection (strength: 50 mg, Sichuan Huiyu Pharmaceutical Co., Ltd.), Amphotericin B Liposome for Injection (trade name: Ambisome®, strength: 50 mg, MAH: Gilead Sciences) - Invasive Fungal Infections, Neutropenic Fever | Not applicable | Completed | Sichuan Huiyu Pharmaceutical Co., Ltd | 42 | 2025-05-13 | 2026-05-22 |
| LEISH-PED: Study on Leishmaniasis in Children Leishmania Infantum Disease, Leishmaniasis, Visceral | Recruiting | Meyer Children's Hospital IRCCS | 200 | 2025-01-30 | 2026-04-01 | |
| Leishmania Antigen Rapid Diagnostic Test Proof-of-Concept and Validation Study Antigen detection Rapid Diagnostic Test prototype - Visceral Leishmaniasis | Terminated | Foundation for Innovative New Diagnostics, Switzerland | 72 | 2023-12-20 | 2025-01-28 | |
| Clinical Prognostic Score to Predict Relapse in VL No intervention - Visceral Leishmaniasis | Recruiting | Institute of Tropical Medicine, Belgium | 741 | 2023-02-03 | 2024-03-05 | |
| Evaluation to Assess the Usability of rK28 for the Diagnosis of Visceral Leishmaniasis in Kenya rK28 - Visceral Leishmaniasis | Unknown | Foundation for Innovative New Diagnostics, Switzerland | 625 | 2022-12-31 | 2023-04-07 | |
| Incidence of Relapse and Post-Kala-Azar Dermal Leishmaniasis in South Sudan Leishmaniasis, Leishmaniasis, Visceral | Completed | Epicentre | 52 | 2022-05-31 | 2025-04-24 | |
| A Study to Assess Immune Response Status in Patients Before and After Treatment for Visceral Leishmaniasis Sodium stibogluconate / paramomycin - Visceral Leishmaniasis | Active not recruiting | University of York | 216 | 2022-05-22 | 2025-07-24 | |
| Evaluation of Less Invasive Procedures for Visceral Leishmaniasis Treatment Efficacy Monitoring Test of Cure ELISA, LAMP, Cytokine Release Assay - Visceral Leishmaniasis | Completed | Foundation for Innovative New Diagnostics, Switzerland | 60 | 2021-09-01 | 2026-09-17 | |
| Real World Study of Classic Infectious Disease Antibiotics - Brucelloses, Epidemic Hemorrhagic Fever | Recruiting | Huashan Hospital | 10000 | 2020-05-13 | 2020-05-14 | |
| Visceral Leishmaniasis in Emilia-Romagna (Leishmania-2019) Leishmaniasis, Visceral | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 300 | 2020-04-21 | 2025-01-27 | |
| Evaluation of Antibody Detection Tests for Visceral Leishmaniasis Diagnosis in Eastern Africa Leishmania Ab Rapid Test (CTK, Biotech) - Leishmaniasis, Visceral | Completed | Foundation for Innovative New Diagnostics, Switzerland | 704 | 2019-09-01 | 2022-06-06 | |
| Single Oral Dose Escalation Study of DNDI-0690 in Healthy Subjects DNDI-0690, Placebo of DNDI-0690 - Visceral Leishmaniasis, Cutaneous Leishmaniases | Phase 1 | Completed | Drugs for Neglected Diseases | 64 | 2019-04-04 | 2022-12-20 |
| A First-in-human, Safety, Tolerability, and Pharmacokinetics Study of LXE408 in Healthy Subjects LXE408, Placebo, Iohexol - Visceral Leishmaniasis, Chagas Disease | Phase 1 | Completed | Novartis Pharmaceuticals | 88 | 2018-12-21 | 2026-09-09 |
| LAMP Assay for the Diagnosis of Visceral Leishmaniasis Visceral Leishmaniasis | Completed | Prof. Dawit Wolday | 500 | 2018-10-01 | 2023-12-20 | |
| Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Condition Amphotericin B Liposome, AmBisome (Amphotericin B) Liposome - Visceral Leishmaniasis | Phase 1 | Completed | Aurobindo Pharma Ltd | 140 | 2018-05-02 | 2019-08-26 |
| Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa Miltefosine, Paromomycin, Sodium stibogluconate - Visceral Leishmaniasis | Phase 3 | Completed | Drugs for Neglected Diseases | 439 | 2018-01-24 | 2024-02-29 |
| Predicting Visceral Leishmaniasis in HIV Infected Patients No intervention - Leishmaniasis, Visceral | Terminated | Institute of Tropical Medicine, Belgium | 566 | 2017-10-11 | 2022-09-09 |
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Leishmaniasis (9) · Leishmaniasis, Cutaneous (4) · Acquired Immunodeficiency Syndrome (2) · Brucellosis (2) · Disease (2) · Febrile Neutropenia (2) · Invasive Fungal Infections (2) · Leishmaniasis, Mucocutaneous (2) · Malnutrition (2) · Recurrence (2) · Chagas Disease (1) · Coinfection (1) · Drug-Related Side Effects and Adverse Reactions (1) · Growth Disorders (1)
Euglenozoa Infections (61) · Infections (61) · Protozoan Infections (61) · Vector Borne Diseases (61) · Parasitic Diseases (60) · Leishmaniasis (52) · Skin Diseases (11) · Skin Diseases, Infectious (11) · Skin and Connective Tissue Diseases (11) · Skin Diseases, Parasitic (10) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Bacterial Infections and Mycoses (4) · RNA Virus Infections (3) · Virus Diseases (3)
liposomal amphotericin B (15) · Paromomycin (10) · miltefosine (10) · Amphotericin B (6) · amphotericin B, deoxycholate drug combination (5) · Antimony Sodium Gluconate (4) · Injections (2) · Long-Term Synaptic Depression (2) · Meglumine Antimoniate (2) · 8-aminoquinoline (1) · Acetylcysteine (1) · Albendazole (1) · Anti-Bacterial Agents (1) · Combined Modality Therapy (1) · Insecticides (1)
Drugs for Neglected Diseases (10) · Banaras Hindu University (8) · Institute of Tropical Medicine, Belgium (6) · International Centre for Diarrhoeal Disease Research, Bangladesh (5) · Foundation for Innovative New Diagnostics, Switzerland (4) · PATH (3) · Access to Advanced Health Institute (AAHI) (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Sichuan Huiyu Pharmaceutical Co., Ltd (2) · University of Brasilia (2) · AB Foundation (1) · Aurobindo Pharma Ltd (1) · Bharat Serums and Vaccines Limited (1) · Epicentre (1) · GlaxoSmithKline (1)
India (16) · Ethiopia (13) · Bangladesh (8) · Kenya (8) · Sudan (6) · Brazil (5) · United States (4) · China (3) · Uganda (3) · Italy (2) · Nepal (2) · Cambodia (1) · Democratic Republic of the Congo (1) · South Sudan (1) · United Kingdom (1)
Shyam Sundar, MD (8) · Ermias Diro, MD (2) · P K Sinha, MD (2) · Qing Wen (2) · Ahmed M Musa, MD PhD (1) · Ahmed M Musa, MD, Prof (1) · Amanuel Haile, MD (1) · Amrendra K Aditya, MD (1) · Ana LT Rabello, MD PhD (1) · Andrea L de Carvalho, MD (1) · Anna Marie Beckmann, PhD (1) · Beena Varghese, Dr (1) · C P Thakur, MD (1) · Carlos HN Costa, MD PhD (1) · Clive Davies, Dr. (1)
PMID 17582067, PMID 17682988, PMID 18781879, PMID 19663597, PMID 19959405, PMID 20126269, PMID 20147716, PMID 21049063, PMID 21129762, PMID 21255828, PMID 21375777, PMID 21633025, PMID 21718522, PMID 22665599, PMID 22724029, PMID 23029576, PMID 24454970, PMID 24743328, PMID 25233346, PMID 26203904, PMID 26496648, PMID 26573827, PMID 27188804, PMID 27627654, PMID 27812090, PMID 28327804, PMID 28558062, PMID 28662034, PMID 29020217, PMID 30188978, PMID 30653490, PMID 30789910, PMID 31593563, PMID 34125865, PMID 34310340, PMID 34789175, PMID 35491421, PMID 36164254, PMID 38608217, PMID 42743918
2018 (1)