145 completed, 9 recruiting, 8 withdrawn, 7 unknown. 44 Not applicable, 42 Phase 1, 39 Phase 2, 22 Phase 3, 22 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ethiopian Antimalarial Therapeutic Efficacy Study 2026 Artemether-Lumefantrine + Primaquine and Chloroquine + Primaquine - Plasmodium Vivax Malaria Without Complication, Plasmodium Falciparum Malaria (Uncomplicated) | Not yet recruiting | Ethiopian Public Health Institute | 1200 | 2026-10-20 | 2026-09-25 | |
| Impact of a Cricket and Black Soldier Fly Larvae-Fortified Cracker on the Gut Microbiome and Iron Status in Malagasy Schoolchildren Cricket and Black Soldier Fly Larvae-fortified Cracker, Rice and Corn Cracker - Gut -Microbiota, Inflamation | Not applicable | Not yet recruiting | Cornell University | 650 | 2026-02-01 | 2026-02-27 |
| Study of Co-administered (Types 1 & 2) Novel Oral Poliomyelitis Vaccines Evaluation Novel Oral Polio Vaccine Type 1 (nOPV1), Novel Oral Polio Vaccine Type 2 (nOPV2), Placebo (Sterile Water) - Poliomyelitis | Phase 2 | Recruiting | PATH | 675 | 2025-11-11 | 2026-01-09 |
| Assessing the Acceptability, Feasibility, Effectiveness and Cost-effectiveness of LADB long-acting depot buprenorphine (LADB) - Opioid Dependence | Not yet recruiting | PATH | 760 | 2025-11-01 | 2025-10-07 | |
| Infant Malaria Vaccine Schedule Optimization R21 Matrix-M (R21/MM) Malaria Vaccine, Placebo, Hexavalent Vaccine - Malaria Vaccines, Malaria (Plasmodium Falciparum) | Phase 2 | Active not recruiting | PATH | 975 | 2025-05-30 | 2026-09-29 |
| MaCRA Part B in Côte d'Ivoire Monthly RDT Validation Meeting - Malaria | Not applicable | Withdrawn | PATH | 2025-04-01 | 2025-03-14 | |
| MaCRA Part B in Nigeria Monthly RDT validation during DHIS2 data review meetings - Malaria | Not applicable | Withdrawn | PATH | 2025-04-01 | 2025-03-14 | |
| Shigella Sonnei 53G Human Infection Study in Kenyan Adults Shigella sonnei 53G, Ciprofloxacin 500 mg - Shigellosis | Phase 1 | Recruiting | University of Oxford | 70 | 2025-01-21 | 2025-03-13 |
| LIFT-UP: Randomized Controlled Trial of Fortification of Human Milk Human Milk Fortifier, Volume targets - Very Preterm Infant, Very Low Birthweight | Not applicable | Recruiting | Harvard School of Public Health (HSPH) | 776 | 2025-01-16 | 2026-01-21 |
| Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Poliomyelitis Vaccines Novel oral poliomyelitis vaccine type 1 (nOPV1), Novel oral poliomyelitis vaccine type 2 (nOPV2), Novel oral poliomyelitis vaccine type 3 (nOPV3) - Poliomyelitis | Phase 1 / Phase 2 | Recruiting | PATH | 2400 | 2024-11-20 | 2025-06-03 |
| Phase I/II Study to a Assess the GBS-06 Vaccine Manufactured by Inventprise, Inc., in Healthy, Non-Pregnant, Adult Women of Childbearing Age. IVT GBS-06, Placebo - Group B Streptococcal Infections | Phase 1 / Phase 2 | Active not recruiting | Inventprise Inc. | 600 | 2024-11-12 | 2025-11-18 |
| FocaL Mass Drug Administration for Vivax Malaria Elimination Focal Mass Drug Administration (fMDA) - Plasmodium Vivax Malaria, Malaria | Phase 3 | Recruiting | University of California, San Francisco | 7530 | 2024-10-14 | 2026-06-09 |
| InvaplexAR-Detox and DmLT Adjuvant in the Netherlands and Zambia 2.5 μg InvaplexAR-Detox, 10 μg InvaplexAR-Detox, 0.1 μg of dmLT - Shigellosis, Bacillary Dysentery | Phase 1 | Recruiting | Leiden University Medical Center | 85 | 2024-10-10 | 2024-11-07 |
| Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test - Drug Use, Hepatitis | Recruiting | Médecins du Monde | 2400 | 2024-09-13 | 2026-10-09 | |
| Targeted Antimalarial Drug Administration for Seasonal Migrant Populations in Amhara Region, Ethiopia Dihydroartemisinin-piperaquine - Plasmodium Falciparum, Malaria | Phase 3 | Active not recruiting | PATH | 10350 | 2024-08-21 | 2025-05-06 |
| Developing a Screening Tool for Primary Immunodeficiency Disease (PID) in Pakistan Primary Immunodeficiency (PID) Rapid Diagnostic Test (RDT) - Primary Immunodeficiency Diseases | Completed | PATH | 200 | 2024-07-01 | 2025-07-31 | |
| Evaluation of an IgG Deficiency Rapid Screening Test: A Performance Study With Primary Immunodeficiency (PID) Patients in Tunisia IgG deficiency rapid screening test - Primary Immunodeficiency Diseases | Completed | PATH | 50 | 2024-05-15 | 2025-07-31 | |
| Low Birthweight and Preterm Infant Feeding Trial and Supportive Care Package: Implementation Research Facility-based feeding support package plus (FB-FSP+), Transition-to-home feeding support package plus (TTH-FSP+) - Low Birthweight, Preterm Birth | Not applicable | Completed | Harvard School of Public Health (HSPH) | 632 | 2024-05-08 | 2026-02-23 |
| A Short Period of Proactive Community Case Management (ProCCM) to Improve Early Care-seeking for Fever in Sierra Leone Proactive community case management, Strengthened SBCC and stock out mitigation - Health Services Research | Not applicable | Unknown | PATH | 9000 | 2024-05-06 | 2024-05-02 |
| Evaluation of Vector and Chemoprevention-based Interventions to Reduce Malaria Burden in Urban Daaras of Touba, Senegal Intervention package - Malaria | Phase 4 | Suspended | PATH | 4600 | 2024-01-19 | 2025-02-17 |
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Malaria (25) · Influenza, Human (17) · Diarrhea (14) · Dysentery, Bacillary (12) · Poliomyelitis (11) · Encephalitis, Japanese (8) · Glucosephosphate Dehydrogenase Deficiency (8) · Malaria, Falciparum (7) · Cholera (4) · Malaria, Vivax (4) · Postpartum Hemorrhage (4) · Premature Birth (4) · Acquired Immunodeficiency Syndrome (3) · Bacterial Infections (3) · Disease (3)
RIX4414 vaccine (10) · Vaccines (6) · PHiD-CV vaccine (4) · Primaquine (4) · Rotavirus Vaccines (4) · Artemether, Lumefantrine Drug Combination (3) · IOWH-032 (3) · Meningococcal Vaccines (3) · Needles (3) · Paromomycin (3) · 13-valent pneumococcal vaccine (2) · Adjuvants, Pharmaceutic (2) · Chloroquine (2) · Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 (2) · Influenza Vaccines (2)
United States (29) · India (17) · Bangladesh (15) · Kenya (15) · Ghana (9) · Zambia (9) · South Africa (8) · Vietnam (8) · Senegal (7) · Burkina Faso (5) · Tanzania (5) · The Gambia (5) · Russia (4) · Belgium (3) · Brazil (3)
Joseph Wagman, PhD (5) · Aldiouma Diallo, MD (3) · Katherine Semrau, PhD, MPH (3) · Clayton D Harro, MD, ScM (2) · Cynthia Stanton, PhD (2) · George Armah, PhD (2) · Gonzalo Domingo, PhD (2) · John C Victor, PhD, MPH (2) · Karen L Kotloff, M.D. (2) · Kaspar Wyss, Prof, PhD (2) · Kathleen M Neuzil, MD, MPH (2) · Kimberly Green (2) · Leslie Klaff, MD, PhD (2) · Megan Parker, PhD (2)
PMID 26432909, PMID 35945599, PMID 36737079, PMID 38218668, PMID 38683158, PMID 40670924, PMID 41576705, PMID 17582067, PMID 18394765, PMID 19545211, PMID 20377407, PMID 21486975, PMID 22676921, PMID 23901077, PMID 24130463, PMID 24374502, PMID 24533064, PMID 24576792, PMID 24629994, PMID 24631328, PMID 25091663, PMID 25239483, PMID 26035743, PMID 26044169, PMID 26065919, PMID 26259809, PMID 26296497, PMID 26496648, PMID 26735845, PMID 26823335, PMID 26823338, PMID 26865592, PMID 27567493, PMID 27591953, PMID 27746224, PMID 27746226, PMID 28135273, PMID 28148685, PMID 28419095, PMID 28483414, PMID 28588962, PMID 28967523, PMID 29028980, PMID 29239682, PMID 29306506, PMID 29395526, PMID 29534721, PMID 29564161, PMID 29659924, PMID 29689045
2017 (1), 2018 (1), 2019 (1), U01AI053719 (1), U01AI061187 (1), U01AI138910 (1), U01AI157962 (1), UM1AI068619 (1)