73 completed, 35 unknown, 12 not yet recruiting, 12 recruiting. 31 Not applicable, 29 Phase 4, 22 Phase 2, 20 Phase 3, 6 Phase 1.
Follow Febrile Neutropenia: new trials by email Literature Review of Febrile Neutropenia trials Research Report on Febrile Neutropenia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Restrictive Versus Standard Antibiotic Treatment During CAR-T Therapy ceftazidime, ciprofloxacin, Standard-of-Care Antibiotic Strategy - Large B-Cell Lymphoma (LBCL), Multiple Myeloma (MM) | Phase 2 | Not yet recruiting | Zealand University Hospital | 150 | 2027-03-01 | 2026-09-25 |
| Diagnostic Accuracy, Clinical Utility and Implementation of Point-of-Care Absolute Neutrophil Count in Suspected Neutropenic Fever (DUCATIS) - Diagnostic Accuracy (S1) Hemocue® WBC DIFF system - Suspected Neutropenic Fever, Confirmed Neutropenic Fever | Not applicable | Not yet recruiting | The University of Hong Kong | 317 | 2027-01-01 | 2026-10-28 |
| Impact of a Telemonitoring Device on the Occurever at Home in Children at Risk of Chemotherapy-Induced Neutropenia Remote temperature monitoring device, Home temperature monitoring by a nurse - Oncopediatrics, Febrile Neutropenia | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de la Réunion | 30 | 2026-12-01 | 2026-10-23 |
| Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma Acupuncture - Febrile Neutropenia, Sarcoma | Not applicable | Not yet recruiting | Shaare Zedek Medical Center | 60 | 2026-12-01 | 2026-04-29 |
| Correlation Between ANC and Bone Pain in Breast Cancer Patients Receiving Long-Acting G-CSF Breast Cancer, Chemotherapy-Induced Neutropenia | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 132 | 2026-09-30 | 2026-09-08 | |
| Phase II Study of QLC2519 in Pediatric Solid Tumor Participants Albipagrastim alf - Pediatric Malignant Solid Tumor, Febrile Neutropenia (FN) | Phase 2 | Recruiting | Qilu Pharmaceutical Co., Ltd. | 18 | 2026-06-26 | 2026-07-24 |
| Plasma Host-Microbe Proteomics to Predict Complications in High-risk Febrile Neutropenia Plasma and DNA sample collection for proteomic and genomic analysis - Febrile Neutropenia | Recruiting | Instituto de Investigación Biomédica de Salamanca | 350 | 2026-06-09 | 2026-06-15 | |
| Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy - Febrile Neutropenia (FN), Pediatric Cancer | Phase 4 | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 136 | 2026-06-01 | 2026-05-15 |
| Efficacy of an Empirical Treatment With Amoxicillin-clavulanate (AC) Compared to the Combination Amoxicillin-clavulanate and Ciprofloxacin (AC+C) in the Outpatient Care of Chemotherapy-induced Fever in Adult Haematology Patients. amoxicillin-clavulanate, Amoxicillin-clavulanate ciprofloxacin - C15.378 | Phase 3 | Not yet recruiting | Versailles Hospital | 1526 | 2026-03-01 | 2026-03-19 |
| Antibiotic Duration and Outcomes in High-Risk Febrile Neutropenia Patients Clinical Stability-Driven Antibiotic Discontinuation Strategy, Standard of Care Antibiotic Duration - Bloodstream Infection, Gram Negative Infections | Not applicable | Recruiting | Valeria Cento | 172 | 2026-02-02 | 2026-09-24 |
| Levofloxacin Prophylaxis to Prevent First Febrile Neutropenia in Pediatric ALL During Induction Phase Levofloxacin, Placebo - Neutropenic Fever, Acute Lymphoblastic Leukemia | Phase 4 | Terminated | Gadjah Mada University | 49 | 2026-01-01 | 2026-10-01 |
| Early Versus Late Stopping of Antibiotics in Adults With High-risk Hematological Malignancies/Receiving Cellular Therapies and Fever Early antibiotic cessation alert - Leukemia, CART Therapy | Not applicable | Recruiting | Peter MacCallum Cancer Centre, Australia | 214 | 2025-12-03 | 2025-12-15 |
| Efficacy of Empirical Anti-Infective Therapy in Neutropenic Febrile Patients. Carbapenems, Anti-Gram-positive agent, Antifungal agent - Febrile Neutropenia | Recruiting | Shanxi Bethune Hospital | 20 | 2025-09-22 | 2025-10-02 | |
| ECM and Monitoring w/ Alio Smart Patch in Cancer Pts Receiving Chemotherapy Alio Smart Patch™ - Febrile Neutropenia | Not applicable | Completed | Case Comprehensive Cancer Center | 35 | 2025-08-06 | 2026-07-24 |
| Clinical Study of Thiopegfilgrastim for Preventing Bone Marrow Suppression in Thoracic Tumor Chemoradiotherapy Mecapegfilgrastim injection, Oral or short-acting granulocyte-stimulating agents - Myelosuppression, Thoracic Neoplasms | Phase 2 | Recruiting | Affiliated Hospital of Nantong University | 30 | 2025-08-01 | 2025-12-11 |
| Pharmacist-Led Education to Improve Neutropenic Precautions in Cancer Patients Pharmacist-Led Neutropenic Education Package - Febrile Neutropenia | Not applicable | Active not recruiting | Jordan University of Science and Technology | 300 | 2025-07-13 | 2026-07-08 |
| Comparison of G-CSF & Antibiotics Versus Antibiotics Alone in Resolution of Febrile Neutropenia G-CSF, Antibiotics only - Febrile Neutropenia, Febrile Neutropenia, Rule of Clinical Decision, Chemotherapy | Phase 4 | Not yet recruiting | King Edward Medical University | 150 | 2025-06-01 | 2025-05-25 |
| Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies Ceftazidime, Ciprofloxacin - Neutropenic Fever, Acute Lymphoblastic Leukemia | Phase 4 | Recruiting | Gadjah Mada University | 120 | 2025-06-01 | 2025-08-22 |
| Human Bioequivalence Study of Liposomal Amphotericin B for Injection Test product (Liposomal amphotericin B for injection, Sichuan Huiyu Pharmaceutical Co., Ltd.), Reference product (AmBisome®, Astellas Pharma US Inc.) - Invasive Fungal Infections, Neutropenic Fever | Not applicable | Completed | Sichuan Huiyu Pharmaceutical Co., Ltd | 58 | 2025-05-25 | 2026-05-27 |
| Human Bioequivalence Study of Amphotericin B Liposome for Injection Amphotericin B Liposome for Injection (strength: 50 mg, Sichuan Huiyu Pharmaceutical Co., Ltd.), Amphotericin B Liposome for Injection (trade name: Ambisome®, strength: 50 mg, MAH: Gilead Sciences) - Invasive Fungal Infections, Neutropenic Fever | Not applicable | Completed | Sichuan Huiyu Pharmaceutical Co., Ltd | 42 | 2025-05-13 | 2026-05-22 |
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Neutropenia (35) · Neoplasms (25) · Breast Neoplasms (18) · Chemotherapy-Induced Febrile Neutropenia (13) · Hematologic Neoplasms (13) · Fever (12) · Sepsis (9) · Leukemia, Myeloid, Acute (7) · Multiple Myeloma (7) · Hematologic Diseases (6) · Infections (5) · Leukemia (5) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Invasive Fungal Infections (4)
Agranulocytosis (154) · Cytopenia (154) · Hemic and Lymphatic Diseases (154) · Leukocyte Disorders (154) · Leukopenia (153) · Hematologic Diseases (148) · Neutropenia (119) · Neoplasms (54) · Neoplasms by Site (37) · Neoplasms by Histologic Type (30) · Pathological Conditions, Signs and Symptoms (28) · Infections (22) · Skin Diseases (19) · Skin and Connective Tissue Diseases (19) · Breast Diseases (18)
Meropenem (10) · Cefepime (7) · Vancomycin (7) · Ceftazidime (6) · Ciprofloxacin (6) · pegfilgrastim (6) · Filgrastim (5) · Amoxicillin-Potassium Clavulanate Combination (4) · Granulocyte Colony-Stimulating Factor (4) · Piperacillin, Tazobactam Drug Combination (4) · pegylated granulocyte colony-stimulating factor (4) · Amikacin (3) · Anti-Bacterial Agents (3) · Injections (3) · Levofloxacin (3)
Pfizer (4) · Amgen (3) · Assistance Publique - Hôpitaux de Paris (3) · Jiangsu HengRui Medicine Co., Ltd. (3) · Lei Li (3) · The University of Hong Kong (3) · Biocad (2) · Brigham and Women's Hospital (2) · Gadjah Mada University (2) · Hospital Universitari de Bellvitge (2) · Insel Gruppe AG, University Hospital Bern (2) · M.D. Anderson Cancer Center (2) · Peter MacCallum Cancer Centre, Australia (2) · Poitiers University Hospital (2) · Qilu Pharmaceutical Co., Ltd. (2)
China (21) · France (19) · United States (19) · Spain (9) · South Korea (8) · Germany (7) · Italy (7) · Australia (6) · Belgium (6) · Netherlands (5) · Poland (5) · Switzerland (5) · Brazil (4) · Bulgaria (4) · Canada (4)
Christa Koenig, MD (2) · Lei Li, M.D. (2) · Nicole Blijlevens, MD PhD (2) · Qing Wen (2) · Abby P Douglas, MBBS PhD FRACP (1) · Abd Al-Rahman AR Awad, PharmD (1) · Adolfo Martinez Tovar, PhD (1) · Alexander Pecheny, PhD (1) · Ali S. Omrani, FRCP (1) · Anatoly Uss, MD/PhD (1) · Anderson B Collier, MD (1) · Andrei Horinko, MD (1)
PMID 23317527, PMID 15770833, PMID 20435233, PMID 24166522, PMID 24237790, PMID 25810005, PMID 28374097, PMID 29140155, PMID 29153975, PMID 29608680, PMID 30208456, PMID 30824956, PMID 31467066, PMID 31554370, PMID 32196898, PMID 32418789, PMID 32423462, PMID 33030582, PMID 33041718, PMID 33225965, PMID 33655413, PMID 34871572, PMID 35365139, PMID 35426046, PMID 35546555, PMID 35691326, PMID 35777413, PMID 35792924, PMID 36228177, PMID 36279134, PMID 37770704, PMID 37788414, PMID 37891616, PMID 38102639, PMID 38400942, PMID 39115709, PMID 39436413, PMID 39533204, PMID 39696092, PMID 40098083, PMID 40396505, PMID 40499967, PMID 41001994, PMID 41290295, PMID 41513548, PMID 41990768, PMID 42164340
2014 (2), 2018 (2), 2023 (1), 2025 (1), P30CA016672 (1), UG1CA189974 (1)