7 completed, 4 recruiting, 3 unknown, 1 active not recruiting. 7 Not applicable, 3 Phase 4, 2 Early Phase 1, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 3, Completed 2, Active not recruiting 1, Unknown 1 |
| Phase 4 | 3 | Completed 3 |
| Early Phase 1 | 2 | Recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow ECT: new trials by email Literature Review of ECT trials Research Report on ECT
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Flumazenil for Benzodiazepine Reversal in Electroconvulsive Therapy Flumazenil, Electroconvulsive therapy (ECT) - Depression - Major Depressive Disorder, Bipolar Disorder (BD) | Not applicable | Recruiting | Anders Jørgensen | 145 | 2026-01-15 | 2026-06-01 |
| Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume) - Esketamine, ECT | Early Phase 1 | Recruiting | Min Su | 220 | 2025-11-25 | 2026-01-07 |
| Metabolomics During ElectroConvulsivoTherapy Electroconvulsive therapy - Major Depressive Episode, ECT | Not applicable | Recruiting | Hôpital le Vinatier | 50 | 2024-03-11 | 2025-07-24 |
| The Efficiency of Simulation-Based Electroconvulsive Therapy Training ECT Simulation Training - ECT, Mental Disorder | Not applicable | Unknown | Fenerbahce University | 72 | 2023-10-02 | 2023-10-02 |
| Amplitude Titration to Improve ECT Clinical Outcomes Soterix Medical Incorporated 4x1 adapter, Traditional ECT device - Depression, ECT | Not applicable | Recruiting | University of New Mexico | 50 | 2023-09-14 | 2026-01-26 |
| Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECT Methohexital, Ketofol - ECT, Depression | Phase 4 | Completed | Medical University of Vienna | 56 | 2022-11-01 | 2026-10-07 |
| The Effectiveness and Safety of Esketamine in Modified Electroconvulsive Therapy Esketamine, Saline - Esketamine, ECT | Early Phase 1 | Unknown | First Affiliated Hospital of Chongqing Medical University | 396 | 2021-08-01 | 2021-07-20 |
| Virtual Reality to Reduce Pre-procedure Anxiety Prior ECT VR-ECT 360o Video, Standard Treatment - ECT, Electroconvulsive Therapy | Not applicable | Completed | Sunnybrook Health Sciences Centre | 66 | 2020-11-27 | 2026-08-13 |
| CET- REM (Correlating ECT Response to EEG Markers) Electroencephalographic (EEG), Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16), Ictal Electroencephalographic (EEG) Measurements - ECT, Treatment Resistant Depression | Not applicable | Active not recruiting | Washington University School of Medicine | 31 | 2020-10-09 | 2025-12-31 |
| Prediction of the Cognitive Effects of Electroconvulsive Therapy Via Machine Learning and Neuroimaging Electroconvulsive Therapy, Medication - Treatment as usual - ECT, Depression | Unknown | University Hospital, Bonn | 180 | 2018-01-02 | 2022-05-25 | |
| Effects of Erythropoietin for Cognitive Side-effects of ECT Erythropoietin, Saline - ECT, Cognitive Impairment | Phase 2 | Completed | Martin Balslev Jørgensen | 60 | 2017-06-26 | 2023-09-21 |
| ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) electroconvulsive therapy (ECT), Ketamine - Treatment Resistant Depression, Electroconvulsive Therapy | Phase 2 / Phase 3 | Completed | Bo Hu | 403 | 2017-04-07 | 2023-09-28 |
| Comparison the Effects of Etomidate and Sevoflurane During Electroconvulsive Therapy Etomidate, Sevoflurane - Anesthesia, ECT | Phase 4 | Completed | Inonu University | 25 | 2017-01-01 | 2019-01-23 |
| Sevoflurane in Electroconvulsive Therapy sevorane - ECT, Anesthesia | Phase 4 | Completed | Inonu University | 25 | 2013-03-01 | 2019-05-16 |
| Optimal Dose of Succinylcholine and Rocuronium for Electroconvulsive Therapy (ECT) Succinylcholine, Rocuronium - Neuromuscular Blockade, ECT | Not applicable | Completed | Massachusetts General Hospital | 45 | 2011-05-01 | 2015-06-02 |
Depression (8) · Depressive Disorder, Major (3) · Bipolar Disorder (2) · Cognitive Dysfunction (2) · Depressive Disorder (2) · Depressive Disorder, Treatment-Resistant (2) · Mental Disorders (2) · Anxiety Disorders (1) · Memory Disorders (1) · Psychological Well-Being (1) · Seizures (1)
Behavior (8) · Behavioral Symptoms (8) · Mental Disorders (6) · Mood Disorders (5) · Depressive Disorder (3) · Bipolar and Related Disorders (2) · Cognition Disorders (2) · Nervous System Diseases (2) · Neurocognitive Disorders (2) · Neurologic Manifestations (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Neurobehavioral Manifestations (1) · Personal Satisfaction (1)
Electroconvulsive Therapy (3) · Sevoflurane (2) · Sodium Chloride (2) · Electroencephalography (1) · Epoetin Alfa (1) · Erythropoietin (1) · Esketamine (1) · Etomidate (1) · Flumazenil (1) · Ketamine (1) · Methohexital (1) · Rocuronium (1) · Succinylcholine (1)
Inonu University (2) · Anders Jørgensen (1) · Bo Hu (1) · Fenerbahce University (1) · First Affiliated Hospital of Chongqing Medical University (1) · Hôpital le Vinatier (1) · Martin Balslev Jørgensen (1) · Massachusetts General Hospital (1) · Medical University of Vienna (1) · Min Su (1) · Sunnybrook Health Sciences Centre (1) · University Hospital, Bonn (1) · University of New Mexico (1) · Washington University School of Medicine (1)
United States (4) · Denmark (2) · Turkey (Türkiye) (2) · Austria (1) · Canada (1) · China (1) · France (1) · Germany (1)
Ala Nozari, MD, PhD (1) · Amit Anand, MD (1) · Fahad Alam (1) · Huseyin Toprak, Professor (1) · Kamilla W. Miskowiak, Prof. (1) · Matthias Eikermann, MD, PhD (1) · MohammadMehdi Kafashan (1) · Rene Hurlemann, Prof. (1) · Su Min (1) · Ulku Ozgul, MD (1)
PMID 11940851, PMID 1260078, PMID 15905753, PMID 23399487, PMID 29436330, PMID 29536616, PMID 29673379, PMID 30572160, PMID 36030576, PMID 37224232, PMID 38128460, PMID 40020048, PMID 40900112
2016 (1), 2025 (1), R61MH125126 (1)