13 completed, 3 recruiting, 3 terminated, 3 unknown. 25 Phase 1, 14 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 25 | Completed 13, Recruiting 3, Terminated 3, Unknown 3, Withdrawn 3 |
| Phase 2 | 14 | Completed 8, Terminated 2, Withdrawn 2, Recruiting 1, Unknown 1 |
Follow Dyspnea: new trials by email Literature Review of Dyspnea trials Research Report on Dyspnea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose-Escalation Study of Artesunate Patients With IPF Artesuante, Placebo capsules - Idiopathic Pulmonary Fibrosis | Phase 1 | Recruiting | Joseph C. Wu | 15 | 2026-08-01 | 2026-08-11 |
| A Dose Escalation Study of NanO2 in Patients With Mild Respiratory Distress dodecafluoropentane (0.025 mL/kg), dodecafluoropentane (0.032 mL/kg), dodecafluoropentane (0.050 mL/kg) - Mild Respiratory Distress | Phase 1 | Recruiting | NuvOx LLC | 18 | 2025-03-13 | 2026-01-28 |
| ExoFlo™ Infusion for Post-Acute COVID-19 and Chronic Post-COVID-19 Syndrome Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles, Saline - Covid19, Postviral Syndrome | Phase 1 / Phase 2 | Withdrawn | Direct Biologics, LLC | 2024-11-01 | 2024-11-22 | |
| The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease. Nitric Oxide, Placebo - Dyspnea | Phase 1 / Phase 2 | Withdrawn | University of Alberta | 2024-09-01 | 2024-09-19 | |
| Impact of Long-acting Bronchodilator- -Corticoid Inhaled Therapy on Ventilation, Lung Function and Breathlessness TRIXEO AEROSPHERE - Copd | Phase 1 / Phase 2 | Recruiting | University Hospital, Lille | 35 | 2023-09-29 | 2025-12-18 |
| Antenatal Dexamethasone for Late Preterm Deliveries Dexamethasone - Respiratory Distress of Newborn, Preterm Birth | Phase 1 | Unknown | Chulalongkorn University | 294 | 2023-08-25 | 2024-02-08 |
| Study of the Safety of Therapeutic Tx With Immunomodulatory MSC in Adults With COVID-19 Infection Requiring Mechanical Ventilation BM-Allo.MSC, Placebo - COVID | Phase 1 | Terminated | ImmunityBio, Inc. | 4 | 2020-08-03 | 2024-09-05 |
| The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD Nitric Oxide, Placebo - Dyspnea | Phase 1 / Phase 2 | Completed | University of Alberta | 140 | 2018-09-04 | 2024-01-11 |
| Inhaled Nebulized Furosemide & Physical Activity-Related Breathlessness CWS, Furosemide, Placebo - Breathlessness | Phase 1 | Unknown | McGill University | 30 | 2016-04-01 | 2017-02-14 |
| Specificity of Dyspnoea Relief With Inhaled Furosemide Furosemide, Saline - Dyspnea | Phase 1 | Completed | Oxford Brookes University | 16 | 2015-10-01 | 2016-08-29 |
| Project 4A: Inspiratory Muscle Training and Diaphragm Strength Bilateral phrenic nerve stimulation and measurement of transdiaphragmatic pressure, Midazolam, Volitional Measurement of Maximal Inspiratory Pressure (MIP) - Sepsis | Phase 1 / Phase 2 | Terminated | University of Florida | 1 | 2015-03-01 | 2018-05-07 |
| Aerosol Inhalation Treatment for Dyspnea - Patients Furosemide, Aerosolized saline - Dyspnea | Phase 1 / Phase 2 | Completed | Beth Israel Deaconess Medical Center | 24 | 2014-11-01 | 2018-01-23 |
| Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure - Respiratory Distress, Lung Injury | Phase 1 | Withdrawn | Children's Hospital of Philadelphia | 2014-03-01 | 2015-09-15 | |
| Acupuncture Feasibility Trial for Dyspnea in Lung Cancer Acupuncture - Lung Cancer, Dyspnea | Phase 1 | Completed | Abramson Cancer Center at Penn Medicine | 12 | 2014-03-01 | 2019-07-23 |
| Feasibility of Slow-paced Respiration Therapy for Treatment of a Symptom Cluster in Pulmonary Arterial Hypertension Slow-paced respiration therapy - Pulmonary Arterial Hypertension | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 10 | 2014-02-01 | 2016-08-31 |
| Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn (TTN) Epinephrine Inhalation Solution, Salbutamol, Saline Inhalants - Transient Tachypnea of the Newborn | Phase 1 | Completed | Ahmed Noaman | 135 | 2014-02-01 | 2021-08-16 |
| Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet Drug Desmopressin administration - Bleeding, Tachycardia | Phase 1 | Completed | University of Ulsan | 25 | 2012-08-01 | 2013-05-13 |
| Breakthrough Dyspnea Fentanyl Study in Cancer Patients Fentanyl, Placebo, Walking Tests - Advanced Cancers, Dyspnea | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 26 | 2012-04-01 | 2014-08-22 |
| Aerosol Inhalation Treatment for Dyspnea Furosemide, Saline - Healthy, Dyspnea | Phase 1 / Phase 2 | Completed | Beth Israel Deaconess Medical Center | 24 | 2011-09-01 | 2017-06-14 |
| Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics Epinephrine Inhalation Aerosol, HFA, Epinephrine Inhalation Aerosol - Asthma, Bronchospasm | Phase 1 / Phase 2 | Completed | Amphastar Pharmaceuticals, Inc. | 23 | 2010-08-01 | 2017-07-25 |
Showing 20 of 25. Sign in to see all of them.
Pulmonary Disease, Chronic Obstructive (4) · Asthma (2) · COVID-19 (2) · Respiratory Sounds (2) · Airway Obstruction (1) · Bronchial Spasm (1) · Cough (1) · Fatigue (1) · Fibrosis (1) · Heart Failure (1) · Hemorrhage (1) · Hypercapnia (1) · Hypertension (1) · Hypoxia (1)
Pathological Conditions, Signs and Symptoms (25) · Respiration Disorders (25) · Respiratory Tract Diseases (25) · Signs and Symptoms (25) · Signs and Symptoms, Respiratory (25) · Lung Diseases (13) · Pathologic Processes (7) · Lung Diseases, Obstructive (6) · Chronic Disease (4) · Disease Attributes (4) · Infections (3) · Bronchial Diseases (2) · Cardiovascular Diseases (2) · Coronaviridae Infections (2) · Coronavirus Infections (2)
Furosemide (4) · Sodium Chloride (3) · Epinephrine (2) · Nitric Oxide (2) · Acupuncture Therapy (1) · Albuterol (1) · Blood Specimen Collection (1) · Continuous Positive Airway Pressure (1) · Dexamethasone (1) · Fentanyl (1) · Inhalation (1) · Midazolam (1) · Physical Therapy Modalities (1) · Surveys and Questionnaires (1) · Yoga (1)
Amphastar Pharmaceuticals, Inc. (2) · Beth Israel Deaconess Medical Center (2) · University of Alberta (2) · Abramson Cancer Center at Penn Medicine (1) · Ahmed Noaman (1) · CES University (1) · Children's Hospital of Philadelphia (1) · Chulalongkorn University (1) · Direct Biologics, LLC (1) · ImmunityBio, Inc. (1) · Joseph C. Wu (1) · M.D. Anderson Cancer Center (1) · McGill University (1) · Noninvasive Medical Technologies, Inc. (1) · NuvOx LLC (1)
United States (11) · Canada (3) · Brazil (1) · France (1) · Germany (1) · South Korea (1) · United Kingdom (1) · Vietnam (1)
Bill Arana (1) · Daniel Martin, Ph.D., PT (1) · David Hui, MD (1) · David Seaberg, MD (1) · Dennis Jensen, Ph.D. (1) · Giovanni Ferrara, MD (1) · Hubert Trubel, MD (1) · Jim Shi, M.D., Ph.D. (1) · Joanna C Grogono, MBBS (1) · Joseph A Tyndall, MD (1) · Joshua Bauml, MD (1) · Joshua Mooney, MD (1) · Kevin Ferguson, MD (1) · Lea Ann Matura, PhD (1)
PMID 19436683, PMID 23830530, PMID 30236110, PMID 30850876, PMID 32150492, PMID 32423275, PMID 41452963, PMID 41784492, PMID 41895703
R01NR012009 (2)