18 completed, 3 active not recruiting, 3 recruiting, 2 terminated. 11 Not applicable, 6 Phase 2, 6 Phase 4, 5 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psychosocial Factors in Dual Diagnosis in a General Hospital Dual Diagnosis, Substance Use Disorder | Recruiting | Hospital Virgen del Puerto | 125 | 2026-03-01 | 2026-10-07 | |
| Virtual Reality (VR-GINSO) as an Complement to Intervention for Alcohol and Cannabis Use in Youth in Residential Care Virtual Reality, Treatment as Usual (TAU) - Dual Diagnosis, Risk Youth | Not applicable | Recruiting | Universidad Francisco de Vitoria | 50 | 2025-12-10 | 2026-09-22 |
| The 15-Mental Project: Implementation and Evaluation of the 15-Mental in a Mental Health Hospital Setting 15-Mental. - Dual Diagnosis, Alcohol Use Disorder | Not applicable | Active not recruiting | University of Southern Denmark | 14 | 2025-11-01 | 2026-07-27 |
| VR Based Therapy to Treat Anxiety in Dual Diagnosis Cognitive Miljeu Therapy, Virtual Reality based CBT for Anxiety - Dual Diagnosis, Psychosis | Not applicable | Unknown | Mental Health Centre Sct. Hans | 30 | 2024-11-01 | 2024-03-18 |
| Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness Motivational Interviewing/Community Reinforcement Approach (MI/CRA), Strengths-Based Outreach and Advocacy (SBOA ), Services as Usual (SAU) - Opioid Use Disorder, Dual Diagnosis | Not applicable | Recruiting | Ohio State University | 300 | 2024-05-06 | 2026-09-10 |
| CRP and S&A for Inpatient Veterans Combined Recovery Program, Stable & Able (S&A) - Alcoholism, Substance-related Disorders | Not applicable | Active not recruiting | VA Office of Research and Development | 197 | 2022-09-06 | 2026-07-21 |
| Cannabidiol for Treatment of Non-affective Psychosis and Cannabis Use Cannabidiol, Risperidone - Dual Diagnosis | Phase 2 | Active not recruiting | Lone Baandrup | 64 | 2021-06-01 | 2026-01-27 |
| Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services Group Motivational Interviewing (GMI), Control Treatment Condition (CT) - Alcoholism, Substance-related Disorders | Not applicable | Completed | VA Office of Research and Development | 185 | 2015-09-30 | 2023-07-27 |
| Trial of Supportive Text Messages for Patients With Alcohol Use Disorder and a Co-morbid Depression Supportive text messages intervention, Control group - Dual Diagnosis | Not applicable | Unknown | St Patrick's Hospital, Ireland | 107 | 2015-03-01 | 2017-10-05 |
| A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users Creatine monohydrate - Depression, Dual Diagnosis | Phase 4 | Completed | Perry Renshaw | 65 | 2014-09-01 | 2025-04-08 |
| Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment? Marijuana, Dronabinol, Placebo - Schizophrenia, Dual Diagnosis | Phase 1 | Completed | Dartmouth-Hitchcock Medical Center | 263 | 2014-07-01 | 2025-12-09 |
| Ondansetron for Bipolar Disorder and Alcohol Use Disorders Ondansetron, Placebo - Bipolar Disorder, Alcohol Use Disorder | Phase 4 | Completed | University of Texas Southwestern Medical Center | 70 | 2014-02-01 | 2021-08-24 |
| Clozapine for Cannabis Use in Schizophrenia Clozapine, Risperidone - Schizophrenia, Cannabis Abuse | Phase 4 | Completed | Dartmouth-Hitchcock Medical Center | 49 | 2013-05-01 | 2020-05-05 |
| Creatine as a Treatment Option for Depression in Methamphetamine Using Females Creatine monohydrate - Depression, Substance Abuse | Phase 4 | Completed | Perry Renshaw | 14 | 2013-01-01 | 2015-06-29 |
| Open-Label Creatine Study for Female Meth Users Creatine monohydrate - Depression, Dual Diagnosis | Not applicable | Terminated | Perry Renshaw | 14 | 2012-01-01 | 2016-05-20 |
| Risperidone and Desipramine in Alcohol Use and Schizophrenia Risperidone + Desipramine - Schizophrenia, Alcoholism | Phase 2 | Completed | Dartmouth-Hitchcock Medical Center | 12 | 2011-12-01 | 2018-03-23 |
| Benefits Management for People With Psychiatric Disabilities Benefits Management, Illness Management and Recovery - Dual Diagnosis, Schizophrenia | Phase 1 | Completed | Yale University | 99 | 2010-08-01 | 2020-03-30 |
| Impact of Group Motivational Interviewing and In-Home-Messaging-Devices for Dually Diagnosed Veterans Arm 1 GMI, Arm 2 IHMD, Arm 3 TCC - Alcohol Dependence, Dual Diagnosis | Not applicable | Completed | VA Office of Research and Development | 180 | 2010-05-03 | 2018-08-08 |
| Cannabis and Schizophrenia: Self-Medication and Agonist Treatment Dronabinol, Cannabis - Schizophrenia, Dual Diagnosis | Phase 1 | Completed | Dartmouth-Hitchcock Medical Center | 12 | 2009-12-01 | 2021-07-12 |
| Abstinence-Linked Money Management Multisite ATM, Individual Drug Counseling - Dual Diagnosis, Cocaine Abuse | Phase 2 | Completed | Yale University | 108 | 2009-12-01 | 2020-03-30 |
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Substance-Related Disorders (18) · Alcoholism (8) · Schizophrenia (7) · Psychotic Disorders (6) · Depression (4) · Bipolar Disorder (3) · Marijuana Abuse (3) · Mental Disorders (2) · Mood Disorders (2) · Agoraphobia (1) · Alcohol Drinking (1) · Antisocial Personality Disorder (1) · Anxiety Disorders (1) · Cocaine-Related Disorders (1) · Depressive Disorder, Major (1)
Chemically-Induced Disorders (24) · Mental Disorders (24) · Schizophrenia Spectrum and Other Psychotic Disorders (9) · Alcohol-Related Disorders (8) · Behavior (7) · Substance-Related Disorders (6) · Behavioral Symptoms (4) · Bipolar and Related Disorders (3) · Mood Disorders (2) · Anxiety Disorders (1) · Depressive Disorder (1) · Drinking Behavior (1) · Narcotic-Related Disorders (1) · Personal Satisfaction (1) · Personality Disorders (1)
Creatine (3) · Risperidone (3) · Clozapine (2) · Dronabinol (2) · Motivational Interviewing (2) · Salvage Therapy (2) · Therapeutics (2) · nabiximols (2) · Cannabidiol (1) · Cognitive Behavioral Therapy (1) · Congresses as Topic (1) · Control Groups (1) · Desipramine (1) · Ondansetron (1)
Dartmouth-Hitchcock Medical Center (6) · VA Office of Research and Development (4) · Perry Renshaw (3) · US Department of Veterans Affairs (2) · Yale University (2) · Hospital Virgen del Puerto (1) · Lone Baandrup (1) · Mental Health Centre Sct. Hans (1) · National Institute on Drug Abuse (NIDA) (1) · Ohio State University (1) · Seinajoki Central Hospital (1) · Sorlandet Hospital HF (1) · St Patrick's Hospital, Ireland (1) · Universidad Francisco de Vitoria (1) · University of Southern Denmark (1)
United States (20) · Denmark (2) · Spain (2) · Finland (1) · Ireland (1) · Norway (1)
Alan I Green, MD (4) · Elizabeth J. Santa Ana, PhD MA BA (3) · Perry Renshaw, MD, PhD, MBA (3) · Christine Timko, PhD (2) · Alan Green, MD (1) · Benjamin Arnfred, phd (1) · Conor Farren, PhD,MRCPsych (1) · E. Sherwood Brown, MD, PhD (1) · Lone Baandrup, MD, PhD (1) · Marc I Rosen, M.D. (1) · Marc I. Rosen, M.D. (1) · Marc I. Rosen, MD (1) · Mary F Brunette, MD (1) · Olli Kampman, MD, PhD (1)
PMID 10737825, PMID 11452841, PMID 12556596, PMID 12710369, PMID 12940684, PMID 14756196, PMID 15063915, PMID 15151360, PMID 16814015, PMID 18161644, PMID 18626300, PMID 20141467, PMID 21396794, PMID 22234379, PMID 22763197, PMID 23497788, PMID 23937090, PMID 25488505, PMID 25902801, PMID 26457568, PMID 27589072, PMID 28049461, PMID 28118514, PMID 28554910, PMID 30049272, PMID 31694664, PMID 34391393, PMID 34690824, PMID 35232419, PMID 38012573, PMID 42449276
R01DA013196 (2), 2018 (1), R01DA012952 (1), R01DA026799 (1), R01DA032533 (1), R01DA034699 (1), R34MH083894 (1)