263 completed, 94 unknown, 79 recruiting, 26 not yet recruiting. 320 Not applicable, 51 Phase 2, 19 Phase 1, 18 Phase 3, 13 Phase 4.
Follow Personality Disorders: new trials by email Literature Review of Personality Disorders trials Research Report on Personality Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metacognitive Interpersonal Therapy for Male Intimate Partner Violence Perpetrators With Personality Disorders Metacognitive Interpersonal Therapy for Male Domestic Offenders, Portuguese adaptation (MIT-MDO-PT) - Intimate Partner Violence, Personality Disorders | Not applicable | Not yet recruiting | Hugo César Vicente | 7 | 2027-01-01 | 2026-09-29 |
| Evaluating the Feasibility and Effects of PULS PULS, TAU - Anti Social Behavior | Not applicable | Not yet recruiting | Karolinska Institutet | 224 | 2027-01-01 | 2026-08-19 |
| Efficacy of "DBT-LIVE", an Identity Skills Training Program, for Borderline Personality Disorder. DBT LIVE, TAU - Treatment 1:Dialectical Behavior Therapy (DBT), Treatment as Usual | Not applicable | Not yet recruiting | Universidad Europea de Valencia | 112 | 2027-01-01 | 2026-07-06 |
| ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder Psilocybin, Psilocybin-Assisted Therapy With Dialectical Behavior Therapy - Borderline Personality Disorder, Borderline Personality Pathology | Phase 1 | Not yet recruiting | University of Minnesota | 18 | 2026-12-01 | 2026-09-22 |
| Online Intervention To Improve Motivation Online Motivation Enhancing Intervention - Schizophrenia Prodromal, SCHIZOPHRENIA 1 (Disorder) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2026-12-01 | 2026-10-13 |
| Neurocomputational Dynamics of Cooperation Social Learning Task Battery, Clinical Cohort, Social Learning Task Battery, Online Cohort - Social Cognition, Personality Disorder | Not applicable | Not yet recruiting | University of Pittsburgh | 1612 | 2026-12-01 | 2026-10-06 |
| tDCS and Symptom Provocation in Treatment-Resistant OCD tDCS session, symptom provocation - Obsessive - Compulsive Disorder | Not applicable | Not yet recruiting | Centre Hospitalier Henri Laborit | 178 | 2026-12-01 | 2026-10-21 |
| Efficacy and Mechanism of Transcranial Temporal Interference Stimulation (tTIS) for Patients With Obsessive-Compulsive Disorders Transcranial Temporal Interference Stimulation - Obsessive - Compulsive Disorder | Not applicable | Recruiting | Beijing HuiLongGuan Hospital | 80 | 2026-10-16 | 2026-09-04 |
| Testing a Peer-led Trauma-focused Intervention for Significant Others of Those With BPD Trauma Recovery Program (official title TBD) - Posttraumatic Stress Disorder, Family Members | Phase 1 | Not yet recruiting | York University | 60 | 2026-10-01 | 2026-07-29 |
| Cohort Study of Obsessive-Compulsive Disorder Obsessive - Compulsive Disorder | Not yet recruiting | Shanghai Mental Health Center | 500 | 2026-09-15 | 2026-09-16 | |
| SONATA Dose Duration LIFU for OCD ATTN201 - Low Intensity Focused Ultrasound - Obsessive - Compulsive Disorder | Phase 2 | Recruiting | University of Pennsylvania | 20 | 2026-09-15 | 2026-10-21 |
| Psilocybin for Treatment of OCD-2 Low Dose Psilocybin, High Dose Psilocybin - Obsessive - Compulsive Disorder | Phase 1 / Phase 2 | Not yet recruiting | Francisco A Moreno | 20 | 2026-09-08 | 2026-05-12 |
| Ketamine Infusion for Symptomatic Improvement in Severe Borderline Personality Disorder IV Ketamine (0.5 mg/kg) Infusion - Two Doses Administered 24 Hours Apart for Severe Borderline Personality Disorder - Infusion of Ketamine in Severe Borderline Personality Disorder, Borderline Personality Disorder (BPD) | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 38 | 2026-09-01 | 2026-05-12 |
| Combining Transcranial Magnetic Stimulation With Emotion Regulation Skills Training in Borderline Personality Disorder Transcranial Magnetic Stimulation (TMS), Emotion Regulation Skills Training - Borderline Personality Disorder (BPD) | Not applicable | Recruiting | Massachusetts General Hospital | 12 | 2026-09-01 | 2026-10-26 |
| Clinical and Biological Correlates of Obsessive-Compulsive Disorder and Online Mindfulness-Based Cognitive Therapy Mindfulness-based Cognitive Therapy for OCD - Obsessive - Compulsive Disorder | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 42 | 2026-08-26 | 2026-09-25 |
| Tracking Risk in Adolescents and Children for Early Identification of Common Mental Disorders High Risk, Depression / Major Depressive Disorder | Not yet recruiting | Shanghai Mental Health Center | 200 | 2026-07-25 | 2026-08-04 | |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture continuous theta burst stimulation (cTBS), Intermittent theta burst stimulation (iTBS), Sham - Psychopathy | Not applicable | Recruiting | University of Colorado, Denver | 60 | 2026-07-13 | 2026-10-08 |
| Integrating Exposure and Response Prevention and Habit Reversal Techniques to Treat a Tourettic Subtype of Obsessive-Compulsive Disorder (Tourettic OCD) Exposure and Response Prevention (ERP), Habit Reversal Training (HbRT, Psychoeducation and Supportive Intervention - Obsessive - Compulsive Disorder, Tic Disorder, Chronic Motor or Vocal | Not applicable | Recruiting | University College London Hospitals | 40 | 2026-07-08 | 2026-07-27 |
| Exploring Equine-Assisted Psychotherapy as an Intervention for Those Who Have Received a Diagnosis of Emotionally Unstable Personality Disorder Equine-Assisted Psychotherapy - Emotionally Unstable Personality Disorder, Borderline Type | Not applicable | Active not recruiting | Cygnet Healthcare | 6 | 2026-06-17 | 2026-06-30 |
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Borderline Personality Disorder (275) · Antisocial Personality Disorder (67) · Psychotic Disorders (58) · Depression (57) · Schizotypal Personality Disorder (49) · Schizophrenia (47) · Anxiety Disorders (44) · Compulsive Personality Disorder (39) · Substance-Related Disorders (37) · Mental Disorders (36) · Self-Injurious Behavior (34) · Bipolar Disorder (33) · Stress Disorders, Post-Traumatic (32) · Obsessive-Compulsive Disorder (23)
Mental Disorders (492) · Behavior (162) · Behavioral Symptoms (119) · Schizophrenia Spectrum and Other Psychotic Disorders (78) · Pathological Conditions, Signs and Symptoms (49) · Mood Disorders (47) · Chemically-Induced Disorders (43) · Signs and Symptoms (42) · Social Behavior (42) · Trauma and Stressor Related Disorders (39) · Stress Disorders, Traumatic (36) · Neurodevelopmental Disorders (35) · Bipolar and Related Disorders (32) · Nervous System Diseases (25)
Therapeutics (34) · Dialectical Behavior Therapy (22) · Cognitive Behavioral Therapy (11) · Transcranial Magnetic Stimulation (11) · Transcranial Direct Current Stimulation (9) · Mentalization-Based Therapy (8) · Exercise (5) · Schema Therapy (5) · Acetylcysteine (4) · Eye Movement Desensitization Reprocessing (4) · Magnetic Resonance Imaging (4) · Palliative Care (4) · Risperidone (4) · Surveys and Questionnaires (4) · Cognitive Remediation (3)
University of Minnesota (9) · Icahn School of Medicine at Mount Sinai (8) · University Hospital, Montpellier (8) · Centre for Addiction and Mental Health (7) · University Hospital, Toulouse (7) · Yale University (7) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (6) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (6) · Karolinska Institutet (6) · Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital (6) · Region Skane (6) · Oslo University Hospital (5) · Shalvata Mental Health Center (5) · Shanghai Mental Health Center (5) · University Hospital, Strasbourg, France (5)
United States (147) · Germany (48) · France (47) · Canada (31) · Spain (27) · Denmark (25) · United Kingdom (24) · Netherlands (22) · Italy (19) · Norway (18) · Sweden (16) · Switzerland (13) · China (10) · Israel (7) · Belgium (6)
Amy Longcore (3) · Marianne Goodman, MD (3) · Adrian Raine (2) · Adrian Raine, DPhil (2) · Alexandra Philipsen, Prof. (2) · Andrada D Neacsiu, PhD (2) · Are Holen, PhD MD (2) · Harold Koenigsberg, MD (2) · Harold W Koenigsberg, MD (2) · Jon E Grant, MD, JD, MPH (2) · Kathleen Thomaes, MD/PhD (2) · Larry J Siever, MD (2) · Lars Mehlum, MD PhD (2)
PMID 32368793, PMID 36375174, PMID 33884617, PMID 32880104, PMID 16013747, PMID 17257517, PMID 28861273, PMID 36803673, PMID 21095016, PMID 22967772, PMID 33947471, PMID 38527104, PMID 39558901, PMID 40014392, PMID 10591283, PMID 10591284, PMID 10637676, PMID 10637677, PMID 10668619, PMID 10720283, PMID 11104313, PMID 11104315, PMID 11104317, PMID 11211363, PMID 11211364, PMID 11211365, PMID 11211366, PMID 11211367, PMID 11294072, PMID 11781034, PMID 12014781, PMID 12108764, PMID 12271808, PMID 12549710, PMID 12795577, PMID 12823075, PMID 12880507, PMID 1403624, PMID 14979218, PMID 14998110, PMID 15060225, PMID 15498733, PMID 15677282, PMID 1580810, PMID 15863743, PMID 15931222, PMID 16051730, PMID 16055815, PMID 16055817, PMID 16101975
2019 (2), 2025 (2), R01MH061017 (2), 2002 (1), 2017 (1), K01MH131872 (1), K05DA015226 (1), K05MH000797 (1), K23DA027720 (1), K23MH071641 (1), K23MH106648 (1), K23MH126211 (1), K23MH139637 (1), KL2RR025754-04 (1), P30DA023026 (1)