28 completed, 5 unknown, 1 enrolling by invitation, 1 not yet recruiting. 28 Not applicable, 3 Phase 1, 3 Phase 2, 2 Early Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Salivary Gland Massage and Olfactory Stimulation for Relieving Feeding Difficulty and Triggering Oral Intake Among People With Dementia SMART program (Salivary gland massage combined with aromatherapy - Experimental, Dementia | Not applicable | Enrolling by invitation | National Cheng Kung University | 30 | 2026-03-16 | 2026-07-01 |
| Effects of Methods on Dry Mouth After Septoplasty Surgery ice water, room temperature water - Septoplasty, Dry Mouth | Not applicable | Not yet recruiting | Ege University | 81 | 2025-03-25 | 2025-04-03 |
| Oral Health Intervention in Adult Primary Care EHR Changes, Medical Staff EHR Training, Clinician CSM theory-based didactic education and skills training, Standard ADA Oral Health Training - Dental Caries, Dry Mouth | Not applicable | Recruiting | Case Western Reserve University | 929 | 2024-09-25 | 2026-10-21 |
| The Effect of Intervention About Dry Mouth and Thirst in Patients With Endotracheal Tube 4°C frozen normal saline gauze - Endotracheal Tube, Thirst | Not applicable | Unknown | Changhua Christian Hospital | 100 | 2024-05-01 | 2024-05-14 |
| Effects of Chewing Gum for Dry Mouth in Diabetes Chewing gum, Standart therapy group - Diabetes (DM), Dry Mouth | Not applicable | Completed | Çankırı Karatekin University | 80 | 2024-02-12 | 2025-07-24 |
| The Effect of Cold Water Spray Application on Dry Mouth and Thirst Symptoms and Comfort of Patients After Endonasal Endoscopic Surgery After Admission to Intensive Care Unit Cold Water Spray Application, Clinical routine practice - Thirst in Intensive Care Unit (ICU) Practice, Thirst; Due to Deprivation of Water | Not applicable | Completed | Saglik Bilimleri Universitesi | 40 | 2024-01-10 | 2025-01-08 |
| Efficacy of Manuka Honey Oral Rinse in Treatment of Xerostomia Manuka Honey, Saline mouthwash - Dry Mouth, Salivary Gland Diseases | Not applicable | Completed | British University In Egypt | 28 | 2023-12-01 | 2024-02-05 |
| Efficacy of Transcutaneous Electrical Nerve Stimulation in Patients With Xerostomia (ETENX) Group experimental - Xerostomia, Dry Mouth | Not applicable | Completed | Universidad de Murcia | 50 | 2023-09-15 | 2024-11-27 |
| A Mouth Education Program for Dry Mouth Mouth Educational Program, Care as Usual - Xerostomia, End of Life | Not applicable | Completed | Leiden University Medical Center | 70 | 2023-06-15 | 2026-04-21 |
| Effect to the Photobiomodulation in the Burning Mouth Syndrome Low frequency laser activated photobiomodulation, Low frequency laser photobiomodulation inactive - Burning Mouth Syndrome, Quality of Life | Not applicable | Completed | University of Santiago de Compostela | 40 | 2023-05-12 | 2024-04-18 |
| Xerostomia in Patients With a Life-limiting Condition or Frailty Pilocarpine, Placebo - Xerostomia, Dry Mouth | Phase 3 | Unknown | Maastricht University Medical Center | 120 | 2023-01-01 | 2022-08-18 |
| Clinical Evaluation of MucoPEG™ for Xerostomia MucoPEG, Biotene - Dry Mouth, Xerostomia | Not applicable | Completed | SunBio, Inc. | 42 | 2022-05-02 | 2025-05-23 |
| Effect of Wearing Face Masks on Salivary Parameters and Halitosis DIY face mask, Surgical face mask, FFP2 respirator mask - Dry Mouth, Halitosis | Not applicable | Completed | University of Göttingen | 40 | 2021-09-28 | 2024-02-14 |
| Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health Invitation to participate - Dry Mouth, Halitosis | Not applicable | Completed | University of Göttingen | 3750 | 2020-11-20 | 2024-02-14 |
| Mesenchymal Stem Cells for Radiation-induced Xerostomia Autologous adipose-derived mesenchymal stem/stromal cells, Placebo - Radiation Toxicity, Xerostomia Due to Radiotherapy | Phase 1 / Phase 2 | Unknown | Copenhagen University Hospital, Rigshospitalet | 30 | 2020-08-01 | 2020-10-22 |
| Improvement of Dry Mouth Sufferers After Using an Experimental Dry Mouth Rinse Compared to a Water Control dry mouth rinse, Water Control - Dry Mouth | Not applicable | Completed | Procter and Gamble | 137 | 2020-05-13 | 2021-05-28 |
| A Pilot Study to Assess Dry Mouth Relief After Using an Experimental Mouth Rinse Marketed Dry Mouth Rinse, Water control, Experimental Dry Mouth Rinse - Dry Mouth | Not applicable | Completed | Procter and Gamble | 22 | 2019-11-04 | 2021-02-02 |
| Oral Care of Intubated Intensive Care Patient oral care bundle, clinical oral care - Pneumonia, Mechanical Ventilation Complication | Not applicable | Completed | Nigde Omer Halisdemir University | 35 | 2019-05-01 | 2024-02-15 |
| Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth Allogeneic adipose derived stem/stromal cells - Xerostomia Due to Radiotherapy, Hyposalivation | Phase 1 | Unknown | Copenhagen University Hospital, Rigshospitalet | 10 | 2019-03-18 | 2021-01-29 |
| Duration of Effect of Biotene Spray in Patients With Dry Mouth Biotene, Placebo - Dry Mouth | Not applicable | Completed | University of Rochester | 37 | 2019-02-11 | 2021-01-20 |
Showing 20 of 37. Sign in to see all of them.
Xerostomia (37) · Halitosis (2) · Head and Neck Neoplasms (2) · Periodontal Diseases (2) · Salivary Gland Diseases (2) · Sjogren's Syndrome (2) · Autoimmune Diseases (1) · Burning Mouth Syndrome (1) · Death (1) · Dementia (1) · Dental Caries (1) · Diabetes Mellitus (1) · Dry Eye Syndromes (1) · Frailty (1) · Gingival Hemorrhage (1)
Mouth Diseases (37) · Stomatognathic Diseases (37) · Salivary Gland Diseases (35) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (4) · Neoplasms by Site (3) · Nervous System Diseases (3) · Pathologic Processes (3) · Arthritis (2) · Arthritis, Rheumatoid (2) · Connective Tissue Diseases (2) · Eye Diseases (2) · Immune System Diseases (2) · Joint Diseases (2) · Lacrimal Apparatus Diseases (2)
Pilocarpine (6) · cevimeline (3) · Aromatherapy (1) · Aspartame (1) · Chewing Gum (1) · Oral Hygiene (1) · Patient Care Bundles (1) · Saliva, Artificial (1) · Toothbrushing (1) · Xylitol (1) · casein phosphopeptide-amorphous calcium phosphate nanocomplex (1) · major intrinsic protein, plant (1)
Roxane Laboratories (6) · Copenhagen University Hospital, Rigshospitalet (2) · Dental Innovation Foundation Under Royal Patronage (2) · Procter and Gamble (2) · University of Göttingen (2) · You First Services (2) · Augusta University (1) · Azad University of Medical Sciences (1) · British University In Egypt (1) · Brock University (1) · Case Western Reserve University (1) · Changhua Christian Hospital (1) · Ege University (1) · Leiden University Medical Center (1) · Maastricht University Medical Center (1)
United States (16) · Turkey (Türkiye) (4) · Denmark (2) · Germany (2) · Spain (2) · Taiwan (2) · Thailand (2) · Canada (1) · Egypt (1) · Iran (1) · Malaysia (1) · Netherlands (1)
Daniel V Freeland, DO (4) · Aroonwan Lam-ubol, DDS, PhD (2) · Charlotte Lynggaard, MD (2) · Darin Brimhall, DO (2) · Cuong Nguyen, PhD (1) · Eda Dolgun, Ass. Prof. (1) · Jeff Milleman, DDS (1) · Joel Thompson, PhD (1) · Malgorzata Klukowska, DDS (1) · Mrs. Vinay Kumari, M.Sc Nursing (1) · Rifqah Nordin, MClinDent (1) · Scott S De Rossi, DMD (1) · Sepideh Banava, Assist-Prof (1) · Suchitra Nelson, PhD (1)
PMID 37612654, PMID 25116914, PMID 25240992, PMID 31732852, PMID 32779011, PMID 33602603, PMID 34501768, PMID 36459058, PMID 38639763, PMID 40410721, PMID 42237271
2014 (1), 2018 (1), 4UH3DE030856-03 (1)