6 terminated, 5 completed. 8 Phase 1, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Completed 4, Terminated 4 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 1 | Terminated 1 |
Follow padsevonil: new trials by email Literature Review of padsevonil trials Research Report on padsevonil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pharmacokinetic Study of Padsevonil in Study Participants With Either Normal or Moderately Impaired Hepatic Function Padsevonil - Healthy Study Participants, Impaired Hepatic Function | Phase 1 | Terminated | UCB Biopharma S.P.R.L. | 12 | 2019-10-28 | 2021-07-28 |
| A Study to Test the Interaction of Padsevonil With Oral Contraceptives in Healthy Female Participants Padsevonil, Microgynon 30® - Healthy Female Participants | Phase 1 | Terminated | UCB Biopharma SRL | 14 | 2019-10-23 | 2021-06-24 |
| A Study to Test the Cardiac Effects of Padsevonil in Healthy Study Participants Padsevonil, Moxifloxacin, Placebo - Healthy Study Participants | Phase 1 | Terminated | UCB Biopharma S.P.R.L. | 54 | 2019-10-23 | 2021-06-18 |
| A Study to Test the Safety, and Tolerability of Padsevonil in Healthy Male Japanese Study Participants Padsevonil - Healthy Japanese Participants | Phase 1 | Completed | UCB Biopharma S.P.R.L. | 39 | 2019-09-30 | 2021-07-08 |
| A Study to Test the Pharmacodynamic, Pharmacokinetic, Safety, and Tolerability of Padsevonil in Healthy Study Participants Receiving Either Ethanol or Cannabidiol Padsevonil, Placebo (PSL) - Healthy Participants | Phase 1 | Terminated | UCB Biopharma S.P.R.L. | 40 | 2019-07-17 | 2021-06-18 |
| A Study to Test the Safety and Tolerability of Single and Multiple Doses of Padsevonil in Adult and Elderly Study Participants Padsevonil - Elderly Study Participants, Adult Study Participants | Phase 1 | Completed | UCB Biopharma S.P.R.L. | 28 | 2019-07-09 | 2021-06-30 |
| A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy Padsevonil, Placebo - Drug-Resistant Epilepsy, Focal-Onset Seizures | Phase 3 | Terminated | UCB Biopharma SRL | 232 | 2019-03-06 | 2022-12-21 |
| A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil Padsevonil, Oxcarbazepine, Levetiracetam - Epilepsy | Phase 1 | Completed | UCB Biopharma S.P.R.L. | 31 | 2018-09-18 | 2020-06-04 |
| Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy Padsevonil - Drug-Resistant Epilepsy, Focal-Onset Seizures | Phase 2 | Terminated | UCB Biopharma SRL | 406 | 2018-08-27 | 2021-12-29 |
| Study to Evaluate the Effect of Coadministered Erythromycin on the Pharmacokinetics and Safety of Padsevonil Padsevonil (UCB0942), Erythromycin - Pharmacokinetics | Phase 1 | Completed | UCB Biopharma S.P.R.L. | 28 | 2018-03-27 | 2021-07-12 |
| Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy Padsevonil, Placebo - Drug-resistant Epilepsy, Focal-Onset Seizures | Phase 2 | Completed | UCB Biopharma S.P.R.L. | 411 | 2018-02-12 | 2023-12-19 |
Drug Resistant Epilepsy (3) · Epilepsy (3) · Seizures (3)
UCB Biopharma S.P.R.L. (8) · UCB Biopharma SRL (3)
United Kingdom (6) · United States (5) · Bulgaria (4) · Japan (4) · Australia (3) · Belgium (3) · Czechia (3) · France (3) · Germany (3) · Hungary (3) · Italy (3) · Poland (3) · Slovakia (3) · Spain (3) · Turkey (Türkiye) (3)
PMID 38932723, PMID 36176044, PMID 37973662
2017 (3), 2019 (3), 2018 (2)