37 completed, 37 recruiting, 27 unknown, 11 not yet recruiting. 129 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 129 | Completed 37, Recruiting 37, Unknown 27, Not yet recruiting 11, Terminated 6, Enrolling by invitation 5, Active not recruiting 4, Withdrawn 2 |
Follow Drug Resistant Epilepsy: new trials by email Literature Review of Drug Resistant Epilepsy trials Research Report on Drug Resistant Epilepsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Characterisation of Laryngeal Evoked Potentials Induced by Vagus Nerve Stimulation in Refractory Epilepsy Patients Increasing VNS Intensities Induced with Magnet - Refractory Epilepsy, Epilepsy | Not applicable | Not yet recruiting | Université Catholique de Louvain | 110 | 2027-01-01 | 2026-10-29 |
| Electrophysiological Dose-Response to Anterior Thalamic Deep Brain Stimulation in Drug-Resistant Focal Epilepsy Anterior thalamic deep brain stimulation with a standardized amplitude schedule and acute stimulation challenges - Drug Resistant Epilepsy, Focal Epilepsy | Not applicable | Not yet recruiting | Yonsei University | 10 | 2026-11-01 | 2026-11-03 |
| Overnight TI in TLE Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi - Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy | Not applicable | Recruiting | Duke University | 20 | 2026-10-15 | 2026-10-16 |
| Sleep Disruption Pattern - Epilepsy Monitoring Unit Alarm system - Epilepsy Intractable | Not applicable | Not yet recruiting | Duke University | 75 | 2026-10-01 | 2026-09-08 |
| Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring Temporal Interference Stimulation, Direct Electrical Stimulation - Drug-Resistant Focal Epilepsy | Not applicable | Recruiting | Duke University | 30 | 2026-09-16 | 2026-10-15 |
| Assessment of MRI-guided HIFU for Patients With Drug-resistant Focal Epilepsy MR-guided HIFU thermoablation, EEG, MRI - Epilepsy | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 13 | 2026-09-01 | 2026-05-15 |
| Feasibility Study of the iVEAcare Neuromodulation System for the Treatment of Drug-Resistant Epilepsy iVEAcare Neuromodulation System - Drug Resistant Epilepsy | Not applicable | Recruiting | iVEAcare | 30 | 2026-07-29 | 2026-09-22 |
| Pediatric Epilepsy Cedrus RB series response pad; Adtech Behnke-Fried micro-electrodes; Neuralynx or Blackrock electrophysiology system; Blackrock Cerestim or Natus Nicolet stimulator - Epilepsy Intractable | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 200 | 2026-07-01 | 2026-10-06 |
| Biomarkers of Response to SEEG Thermocoagulation Quality of life questionnaires (QOLIE, EFIQUACEE for children), psychiatric questionnaires (NDDIE, GAD-7, PCL-5) at Visit 1 (V1), V5, V6 and V7, Resting state SEEG recording 30min before and 30 min after RFTC, Blood sample at Visit 1 (V1), V2, V4 and V5 - Drug Resistant Epilepsy | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 45 | 2026-06-19 | 2026-06-26 |
| A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome [18F]MPPF PET-MRI - Epilepsy, Dravet Syndrome | Not applicable | Recruiting | Hospices Civils de Lyon | 30 | 2026-05-04 | 2026-05-08 |
| Neuronal Mechanisms of Learning and Utilizing Abstract Representations Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator - Epilepsy Intractable | Not applicable | Enrolling by invitation | Cedars-Sinai Medical Center | 114 | 2026-03-30 | 2026-09-15 |
| MRgFUS for Childhood Epilepsy Ablation - Drug Resistant Epilepsy, Epilepsy | Not applicable | Not yet recruiting | The Hospital for Sick Children | 20 | 2026-03-01 | 2026-03-27 |
| Evaluation of the Efficacy of Neurofeedback Technique Based on EEG Desynchronization in Epileptic Patients Neurofeedback, Sham-NFB - Epilepsy, Drug Resistant Epilepsy | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 22 | 2026-03-01 | 2026-01-21 |
| Occupational Therapy Approach in ARX-Related Epilepsy Occupational Therapy, Medikal Ketogenic Diet Therapy - Drug-Resistant Epilepsy, ARX-Related Epilepsy | Not applicable | Completed | Uskudar University | 20 | 2026-02-02 | 2026-08-07 |
| Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG SEEG recordings and SPES - Refractory Epilepsy, Neuromodulation | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 10 | 2025-12-08 | 2025-12-26 |
| Infrared Photobiomodulation in Humans With Epilepsy photobiomodulation - Drug Resistant Epilepsy | Not applicable | Recruiting | Beth Israel Deaconess Medical Center | 13 | 2025-11-25 | 2026-02-04 |
| Modified Ketogenic Diet on Drug-Resistant Epilepsy in Adults - a Prospective Observational Study of Real-world Data Modified ketogenic diet - Drug-Resistant Epilepsy | Not applicable | Recruiting | Karolinska Institutet | 150 | 2025-10-10 | 2026-10-16 |
| Piriform Cortex Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis piriform cortex-DBS - Epilepsy, Drug Resistant | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 5 | 2025-09-10 | 2025-08-19 |
| VNS Algorithm for Advanced Dosing Rapid Titration VNS programming, Standard VNS programming - Epilepsies | Not applicable | Recruiting | Fernando Vale | 80 | 2025-08-01 | 2026-07-24 |
| Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application Experimental Intervention (Music A), Active Comparator Intervention (Music B), Active Comparator Intervention (Music C) - Epilepsy, Refractory Epilepsy | Not applicable | Recruiting | Dartmouth-Hitchcock Medical Center | 24 | 2025-07-22 | 2026-05-20 |
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Epilepsy (43) · Epilepsies, Partial (14) · Seizures (14) · Epilepsy, Temporal Lobe (5) · Epilepsy, Generalized (2) · Epilepsy, Tonic-Clonic (2) · Glut1 Deficiency Syndrome (2) · Anxiety Disorders (1) · Attention Deficit Disorder with Hyperactivity (1) · Brain Diseases (1) · CDKL5 deficiency disorder (1) · Central Nervous System Diseases (1) · Disease (1) · Epilepsies, Myoclonic (1)
Brain Diseases (128) · Central Nervous System Diseases (128) · Nervous System Diseases (128) · Epilepsy (86) · Pathological Conditions, Signs and Symptoms (18) · Neurologic Manifestations (16) · Signs and Symptoms (16) · Epileptic Syndromes (7) · Behavior (5) · Epilepsies, Partial (5) · Epilepsy, Generalized (3) · Neurobehavioral Manifestations (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Consciousness Disorders (2) · Mental Disorders (2)
Transcranial Direct Current Stimulation (7) · Diet, Ketogenic (3) · Electroencephalography (2) · Surveys and Questionnaires (2) · Therapeutics (2) · Transcranial Magnetic Stimulation (2) · Anticonvulsants (1) · Blood Specimen Collection (1) · Deep Brain Stimulation (1) · Diet (1) · Dietary Supplements (1) · Drug Therapy (1) · Electric Stimulation (1) · Electrodes (1) · Evoked Potentials (1)
Xuanwu Hospital, Beijing (10) · Assistance Publique Hopitaux De Marseille (4) · Cedars-Sinai Medical Center (4) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (4) · Duke University (4) · Beijing Pins Medical Co., Ltd (3) · Hospices Civils de Lyon (3) · NaviFUS Corporation (3) · Xijing Hospital (3) · All India Institute of Medical Sciences (2) · Assistance Publique - Hôpitaux de Paris (2) · Dartmouth-Hitchcock Medical Center (2) · Great Ormond Street Hospital for Children NHS Foundation Trust (2) · Neuroelectrics Corporation (2) · The Hospital for Sick Children (2)
United States (35) · China (18) · France (11) · Belgium (8) · United Kingdom (6) · Taiwan (5) · Italy (4) · Canada (3) · India (3) · Spain (3) · Turkey (Türkiye) (3) · Australia (2) · Czechia (2) · Denmark (2) · Germany (2)
Liankun Ren, MD (8) · Adam Mamelak, MD (4) · Ueli Rutishauser, PhD (4) · Birgit Frauscher, MD PD (2) · Liankun Ren (2) · Aaron Boes, MD, PhD (1) · Adam Williamson, PhD (1) · Alexander Rotenberg, MD, PhD (1) · Alfred Meurs, MD PhD (1) · Allison Waters (1) · Ammar Khalil (1) · Andreas Schulze Bonhage, MD (1) · Andrey A Zuev, MD, PhD (1) · Angel Aledo-Serrano, MD, PhD (1) · Angela V Price, M.D. (1)
PMID 32588435, PMID 10332020, PMID 10356376, PMID 10660394, PMID 10742367, PMID 10870204, PMID 10996924, PMID 11188984, PMID 11254763, PMID 11299481, PMID 11971127, PMID 12436398, PMID 1418457, PMID 15816939, PMID 16158066, PMID 16189532, PMID 16499772, PMID 17444813, PMID 17641989, PMID 17642053, PMID 17880009, PMID 17903391, PMID 19889013, PMID 19914135, PMID 21885255, PMID 22278892, PMID 24791078, PMID 25149833, PMID 25232151, PMID 29312132, PMID 30198325, PMID 30642370, PMID 32690786, PMID 32761191, PMID 34862297, PMID 35132096, PMID 35386419, PMID 35833911, PMID 36512398, PMID 36867910, PMID 37800596, PMID 38402708, PMID 39541289, PMID 39612345, PMID 42236101, PMID 42360174, PMID 42401244, PMID 5166216, PMID 8641240
2023 (1), K23NS126495 (1), R00NS126715 (1), R01MH133729 (1), R01MH134990 (1), R01NS106611 (1), R01NS119483 (1), R21MH120441 (1), R21MH124674 (1), R21MH126968 (1), R56NS148323 (1), R61DC022835 (1), U01NS113198 (1), U01NS117839 (1)