21 completed, 4 recruiting, 2 enrolling by invitation, 2 unknown. 14 Not applicable, 9 Phase 2, 4 Phase 3, 2 Early Phase 1, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-Label Study of ML-007C-MA in Adults With Alzheimer's Disease Psychosis ML-007C-MA - Psychosis Associated With Alzheimer's Disease | Phase 2 | Enrolling by invitation | MapLight Therapeutics | 210 | 2026-03-25 | 2026-08-07 |
| A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis ML-007C-MA, Placebo - Psychosis Associated With Alzheimer's Disease | Phase 2 | Recruiting | MapLight Therapeutics | 300 | 2025-08-15 | 2026-09-30 |
| Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy Cognitive Behavioral Therapy, TAU - Schizophrenia Disorders | Not applicable | Recruiting | Vanderbilt University Medical Center | 120 | 2025-01-15 | 2026-09-30 |
| ACP-204 in Adults With Alzheimer's Disease Psychosis Open Label Extension Study ACP-204 - Alzheimer's Disease Psychosis | Phase 3 | Enrolling by invitation | ACADIA Pharmaceuticals Inc. | 752 | 2024-04-23 | 2026-08-05 |
| ACP-204 in Adults With Alzheimer's Disease Psychosis ACP-204, Placebo - Alzheimer's Disease Psychosis | Phase 2 / Phase 3 | Recruiting | ACADIA Pharmaceuticals Inc. | 1074 | 2023-11-14 | 2026-10-19 |
| Delusion Ideation in the Context of Everyday Life Blended face-to-face and smartphone intervention - Psychotic Disorder | Not applicable | Unknown | Charite University, Berlin, Germany | 15 | 2023-04-06 | 2024-01-17 |
| Pimavanserin for Sleep in Parkinson Disease Pimavanserin - Parkinson Disease | Early Phase 1 | Withdrawn | State University of New York - Downstate Medical Center | 2023-01-27 | 2024-12-20 | |
| Effect of Applying Cognitive Defusion Techniques on Mindful Awareness, Cognitive Fusion and Believability of Delusions Among Clients With Schizophrenia cognitive defusion techniques - Schizophrenia; Psychosis, Nurse's Role | Not applicable | Completed | Alexandria University | 70 | 2022-09-10 | 2023-07-19 |
| Comparing Antipsychotic Medications in LBD Over Time Pimavanserin, Quetiapine - Parkinson's Disease Psychosis, Dementia With Lewy Bodies | Phase 4 | Recruiting | The University of Texas Health Science Center at San Antonio | 94 | 2022-04-22 | 2025-09-09 |
| Metacognitive Training as a Serious Game Metacognitive training game, Control games - Schizophrenia and Related Disorders, Psychotic Disorders | Not applicable | Unknown | Christina Andreou | 36 | 2021-06-01 | 2023-05-10 |
| Face Your Fears: Cognitive Behavioural Virtual Reality Therapy for "Paranoia". Cognitive Behavioural Virtual Reality Therapy., Traditional Cognitive Behavioural Therapy - Paranoid Schizophrenia, Schizophrenia and Related Disorders | Not applicable | Completed | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | 259 | 2021-04-09 | 2026-08-12 |
| Intervention to Improve Coping With Negative Emotions in Patients With Psychosis (Feel-Good-Study) Feel-Good- Group - Early Psychosis, Delusions | Early Phase 1 | Completed | Philipps University Marburg | 36 | 2021-01-08 | 2022-05-05 |
| Characterization and Progression of Minor Phenomena in Parkinson's Disease (PD) Observation of minor phenomena - Parkinson Disease, Parkinson Disease Psychosis | Completed | University of Rochester | 38 | 2019-04-25 | 2024-03-08 | |
| Enhancement of Treatment of Delusions in Schizophrenia Through Neuromodulation Metacognitive Training (MCT), Sham/MCT, transcranial alternating current stimulation (tACS) - Schizophrenia, Psychosis | Not applicable | Withdrawn | University of British Columbia | 2019-02-01 | 2021-01-08 | |
| Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis Placebo, Pimavanserin 34 mg, Pimavanserin 20 mg - Dementia-related Psychosis | Phase 3 | Completed | ACADIA Pharmaceuticals Inc. | 392 | 2017-09-27 | 2021-06-21 |
| Efficacy and Mechanisms of Change of an Emotion-oriented Version of Cognitive-behavioral Therapy for Psychosis emotion-oriented Cognitive Behavior Therapy - Schizophrenia, Psychotic Disorders | Not applicable | Completed | Philipps University Marburg | 94 | 2016-05-01 | 2020-03-05 |
| Effect of 4-session Metacognitive Training in Chinese Adult Outpatients With Schizophrenia Spectrum Disorders and Major Depressive Disorder Metacognitive Training - Delusions, Depression | Not applicable | Completed | Chinese University of Hong Kong | 113 | 2015-04-01 | 2020-01-23 |
| Self Directed Positive Parenting Program (Triple P) for Psychosis: A Clinical Case Series Self Directed Positive Parenting Program - Schizophrenia, Spectrum | Not applicable | Completed | University of Manchester | 1 | 2014-06-01 | 2016-08-02 |
| Treatment of Psychosis and Agitation in Alzheimer's Disease Lithium, Placebo - Alzheimer's Disease, Psychosis | Phase 2 | Completed | New York State Psychiatric Institute | 77 | 2014-06-01 | 2024-05-02 |
| D-Cycloserine Augmentation of Cognitive Behavioral Therapy for Delusions D-Cycloserine, Placebo, Cognitive Behavioral Therapy - Schizophrenia, Schizoaffective Disorder | Phase 4 | Completed | NYU Langone Health | 58 | 2014-02-01 | 2020-03-25 |
Showing 20 of 31. Sign in to see all of them.
Psychotic Disorders (24) · Hallucinations (17) · Schizophrenia (16) · Alzheimer Disease (6) · Dementia (6) · Mental Disorders (6) · Paranoid Disorders (5) · Schizophrenia, Paranoid (4) · Aggression (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Emotional Regulation (2) · Lewy Body Disease (2) · Nervous System Diseases (2)
Behavior (31) · Behavioral Symptoms (30) · Schizophrenia Spectrum and Other Psychotic Disorders (24) · Mental Disorders (21) · Nervous System Diseases (17) · Neurobehavioral Manifestations (17) · Neurologic Manifestations (17) · Pathological Conditions, Signs and Symptoms (17) · Perceptual Disorders (17) · Signs and Symptoms (17) · Brain Diseases (8) · Central Nervous System Diseases (8) · Neurocognitive Disorders (7) · Neurodegenerative Diseases (7) · Basal Ganglia Diseases (5)
pimavanserin (4) · Cognitive Behavioral Therapy (3) · Citalopram (2) · Quetiapine Fumarate (2) · Risperidone (2) · 3-(6-p-tolylpyridin-3-yloxy)-1-azabicyclo(2.2.2)octane (1) · Acceptance and Commitment Therapy (1) · Cognitive Remediation (1) · Cycloserine (1) · Inosine Monophosphate (1) · Lithium (1) · Lithium Carbonate (1) · Olanzapine (1) · Single Person (1) · Sugars (1)
ACADIA Pharmaceuticals Inc. (4) · MapLight Therapeutics (2) · National Institute of Mental Health (NIMH) (2) · New York State Psychiatric Institute (2) · Philipps University Marburg (2) · Weill Medical College of Cornell University (2) · Alexandria University (1) · Charite University, Berlin, Germany (1) · Chinese University of Hong Kong (1) · Christina Andreou (1) · Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital (1) · NYU Langone Health (1) · Novartis Pharmaceuticals (1) · State University of New York - Downstate Medical Center (1) · The University of Texas Health Science Center at San Antonio (1)
United States (19) · Germany (7) · Bulgaria (5) · France (5) · Chile (4) · Czechia (4) · Italy (4) · Serbia (4) · Brazil (3) · South Korea (3) · Spain (3) · Canada (2) · Mexico (2) · Poland (2) · Slovakia (2)
Andreas Bechdolf, MD (1) · Ayman Mohamed El-Ashry, PHD (1) · Bruce G. Pollock, MD, PhD (1) · Christian J Amlang, MD (1) · Christina Andreou, PD Dr. (1) · DP Devanand, MD (1) · Daniel van Kammen, MD, PhD (1) · David Kimhy, Ph.D. (1) · Donald C Goff, MD (1) · Karen F Berman, M.D. (1) · Karolina Leopold, MD (1) · Lon Schneider, MD (1) · Nikola M Stenzel, Ph. D. (1)
PMID 17035647, PMID 17984395, PMID 18519523, PMID 19369318, PMID 20214847, PMID 20625270, PMID 28215900, PMID 29045769, PMID 29859917, PMID 30050047, PMID 30535067, PMID 32074412, PMID 32105124, PMID 33176899, PMID 33211503, PMID 33558239, PMID 34059401, PMID 34289275, PMID 34934801, PMID 35017298, PMID 36186856, PMID 37633900, PMID 37732619, PMID 38736628, PMID 39435124, PMID 39730881, PMID 40804323, PMID 41286676, PMID 41640857, PMID 41702910, PMID 42037481
2017 (1), 2025 (1), K23MH077653 (1), N01MH090001 (1), N01MH90001 (1), R01AG047146 (1), R01MH059666 (1), R01MH137024 (1)