18 recruiting. 18 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Recruiting 18 |
| Phase 1 | 3 | Recruiting 3 |
| Phase 3 | 2 | Recruiting 2 |
Follow Communication Disorders: new trials by email Literature Review of Communication Disorders trials Research Report on Communication Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation tDCS - Aphasia, Broca's Aphasia | Phase 2 / Phase 3 | Recruiting | University of South Carolina | 130 | 2026-07-14 | 2026-07-21 |
| Lumateperone in the Treatment of Stuttering, Childhood Onset Fluency Disorder Lumateperone (ITI-007), Placebo Tablet or Capsule - Stuttering, Adult | Phase 2 | Recruiting | CSTrials Inc. | 24 | 2026-04-18 | 2026-07-29 |
| Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial Xylitol Chewing gum, Sorbitol chewing gum - Preterm Birth, Low Birthweight Neonate | Phase 2 / Phase 3 | Recruiting | University of Washington | 6000 | 2026-03-26 | 2026-09-10 |
| Exploratory Evaluation of the Digital Therapeutic Device Zenicom for Subacute Stroke Aphasia Zenicog, Conventional Speech Therapy - Aphasia, Stroke | Phase 2 | Recruiting | Seoul National University Bundang Hospital | 20 | 2025-12-10 | 2026-02-10 |
| Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST) Semantic Feature Analysis (traditional), Semantic Feature Analysis + Metacognitive Strategy Training - Aphasia, Aphasia Following Cerebral Infarction | Phase 2 | Recruiting | Teachers College, Columbia University | 40 | 2025-07-28 | 2026-06-25 |
| A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise, Placebo Drug With Engineered Sound - Central Auditory Processing Disorder, Hearing Impaired (Partially) | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 344 | 2025-03-31 | 2026-04-30 |
| Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia Transcranial Magnetic Stimulation (TMS), Speech-Language Therapy (SLT) - Aphasia, Stroke | Phase 2 | Recruiting | University of Pennsylvania | 24 | 2025-02-11 | 2026-03-05 |
| Generalization With AI Navigation Using StaRt AI-guided maintenance training with visual-acoustic biofeedback, Treatment as Usual (TAU) - Speech Sound Disorder | Phase 2 | Recruiting | New York University | 76 | 2024-12-18 | 2026-05-13 |
| Communication Bridge 3 Study Communication Bridge™, Evidence-Based Impairment Focused - Primary Progressive Aphasia | Phase 2 | Recruiting | University of Chicago | 200 | 2024-08-23 | 2026-06-01 |
| Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia Transcranial Magnetic Stimulation (TMS), Modified Constraint Induced Language Therapy (mCILT) - Stroke, Aphasia | Phase 2 | Recruiting | University of Pennsylvania | 63 | 2024-08-01 | 2026-06-18 |
| Visual-acoustic Intervention With Service Delivery In-person and Via Telepractice Trial Visual-acoustic biofeedback - Speech Sound Disorder | Phase 2 | Recruiting | New York University | 76 | 2024-07-01 | 2025-06-25 |
| Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia Active tDCS + Language Therapy, Sham tDCS + Language Therapy - Primary Progressive Aphasia, Logopenic Progressive Aphasia | Phase 2 | Recruiting | Johns Hopkins University | 180 | 2024-02-13 | 2026-05-05 |
| Adaptive Trial Scheduling in Naming Treatment for Aphasia Adaptive Spacing Condition, High-Item Non-Adaptive Spacing Condition, Low-Item Non-Adaptive Spacing Condition - Aphasia, Stroke | Phase 2 | Recruiting | University of Pittsburgh | 32 | 2023-12-06 | 2025-12-11 |
| Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia Accuracy-maximized condition, Effort-maximized condition, Effort-accuracy balanced condition - Aphasia, Stroke | Phase 2 | Recruiting | University of Pittsburgh | 30 | 2023-11-27 | 2026-04-13 |
| Intensive Speech Motor Chaining Treatment for Residual Speech Sound Disorders Speech Motor Chaining - Speech Sound Disorder | Phase 1 / Phase 2 | Recruiting | Syracuse University | 84 | 2023-10-26 | 2026-01-13 |
| A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) Intrathalamic AAV.PGRN administration, Intrathalamic AVB-101 - Frontotemporal Dementia, FTD | Phase 1 / Phase 2 | Recruiting | AviadoBio Ltd | 18 | 2023-08-30 | 2026-08-13 |
| Escitalopram and Language Intervention for Subacute Aphasia Escitalopram 10mg, Placebo, Computer-delivered naming treatment - Aphasia, Stroke | Phase 2 | Recruiting | Johns Hopkins University | 88 | 2021-07-18 | 2026-09-03 |
| Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism Levoleucovorin Calcium, Placebo - Autism Spectrum Disorder, Language Disorders | Phase 2 | Recruiting | Southwest Autism Research & Resource Center | 80 | 2020-10-08 | 2026-04-27 |
Aphasia (9) · Stroke (8) · Aphasia, Primary Progressive (3) · Speech Sound Disorder (3) · Aphasia, Broca (2) · Communication (2) · Dementia (2) · Frontotemporal Dementia (2) · Speech (2) · Alzheimer Disease (1) · Anomia (1) · Aphasia, Conduction (1) · Auditory Diseases, Central (1) · Autism Spectrum Disorder (1) · Gingivitis (1)
Nervous System Diseases (15) · Neurobehavioral Manifestations (15) · Neurologic Manifestations (15) · Pathological Conditions, Signs and Symptoms (15) · Signs and Symptoms (15) · Language Disorders (13) · Brain Diseases (12) · Central Nervous System Diseases (12) · Speech Disorders (12) · Cardiovascular Diseases (8) · Cerebrovascular Disorders (8) · Mental Disorders (8) · Vascular Diseases (8) · Neurodevelopmental Disorders (5)
Transcranial Magnetic Stimulation (2) · Capsules (1) · Clemastine (1) · Escitalopram (1) · Language Therapy (1) · Leucovorin (1) · Placebo Effect (1) · Speech Therapy (1) · Therapeutics (1) · Transcranial Direct Current Stimulation (1) · lumateperone (1)
Johns Hopkins University (2) · New York University (2) · University of Pennsylvania (2) · University of Pittsburgh (2) · AviadoBio Ltd (1) · CSTrials Inc. (1) · Seoul National University Bundang Hospital (1) · Southwest Autism Research & Resource Center (1) · Syracuse University (1) · Teachers College, Columbia University (1) · University of Chicago (1) · University of Colorado, Denver (1) · University of South Carolina (1) · University of Washington (1)
United States (16) · Canada (2) · Belgium (1) · Italy (1) · Malawi (1) · Netherlands (1) · Poland (1) · South Korea (1) · Spain (1) · Sweden (1) · United Kingdom (1)
H. Branch Coslett, MD (2) · William Evans, PhD (2) · Achim Klug, PhD (1) · Argye Hillis-Trupe, MD (1) · Emily Roglaski, PhD (1) · Gerald A Maguire, MD (1) · Greg Valentine (1) · Jonathan Preston, PhD (1) · Kyrana Tsapkini, PhD. (1) · Richard E Frye, MD, PhD (1) · Samuel A Budoff, PhD, MS (1)
PMID 28738099, PMID 31369655, PMID 33642973, PMID 34941929, PMID 39871189, PMID 42161555
R01DC017476 (2), R01DC019325 (2), 2023 (1), P50DC014664 (1), R01AG055425 (1), R01AG075111 (1), R01DC020959 (1), R01HD119029 (1), R21DC021833 (1), U01DC022447 (1)