25 completed, 5 recruiting, 4 unknown, 3 terminated. 39 Phase 1, 14 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 39 | Completed 25, Recruiting 5, Unknown 4, Terminated 3, Enrolling by invitation 1, Withdrawn 1 |
| Phase 2 | 14 | Completed 8, Recruiting 3, Terminated 2, Enrolling by invitation 1 |
Follow Communication Disorders: new trials by email Literature Review of Communication Disorders trials Research Report on Communication Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autism Spectrum Disorder (ASD) Neurodevelopmental Disorder With Issues Social Behavior, Communication Issues, GI Dysfunction. Study is Multimodal Interventions Targeting These Pathways With cSVF, Stored MSCs, FMT and Diet Modification. Role of Autoimmunity, Gut-brain Issues, & Issues Examined. Autologous MSC isolation, concentration, and cryopreservation of adult mesenchymal stem cells, Fecal Biomicrome Transplantation (FMT), Ketogenic RESET Diet Protocol - Autism Spectrum Disorder, Autism | Phase 1 / Phase 2 | Enrolling by invitation | Black Tie Medical, Inc. | 50 | 2026-04-30 | 2026-04-27 |
| Dopamine and Sensorimotor Function in Stuttering Aripiprazole 10 MG, Placebo - Stuttering, Adult | Phase 1 | Recruiting | University of California, San Francisco | 25 | 2025-09-30 | 2026-08-19 |
| A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound Clemastine Fumarate Combined With Engineered Sound, Clemastine Fumarate Combined With Pink Noise, Placebo Drug With Engineered Sound - Central Auditory Processing Disorder, Hearing Impaired (Partially) | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 344 | 2025-03-31 | 2026-04-30 |
| Treatment Targets in Spanish and English Bilingual Speech Intervention Speech Intervention - Speech Sound Disorder | Phase 1 | Recruiting | Philip Combiths | 16 | 2024-05-08 | 2025-09-05 |
| Intensive Speech Motor Chaining Treatment for Residual Speech Sound Disorders Speech Motor Chaining - Speech Sound Disorder | Phase 1 / Phase 2 | Recruiting | Syracuse University | 84 | 2023-10-26 | 2026-01-13 |
| A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) Intrathalamic AAV.PGRN administration, Intrathalamic AVB-101 - Frontotemporal Dementia, FTD | Phase 1 / Phase 2 | Recruiting | AviadoBio Ltd | 18 | 2023-08-30 | 2026-08-13 |
| Wellbeing After Stroke (WAterS): Supporting Adjustment and Wellbeing After Stroke Acceptance and Commitment Therapy - Stroke, Psychological Distress | Phase 1 | Completed | University of Manchester | 20 | 2021-01-05 | 2024-05-10 |
| Initiation of Acid Suppression Therapy Prospective Outcomes for Laryngomalacia Famotidine, Speech Language Therapy - Laryngomalacia, Gastro Esophageal Reflux | Phase 1 / Phase 2 | Terminated | Reema Padia | 65 | 2020-11-18 | 2025-07-20 |
| Comparing Traditional and Biofeedback Telepractice Treatment for Residual Speech Errors Visual-acoustic biofeedback, Motor-based treatment - Speech Sound Disorder | Phase 1 | Completed | New York University | 7 | 2020-09-01 | 2023-02-13 |
| Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S QBS10072S - Astrocytoma, Brain Cancer | Phase 1 | Completed | Quadriga Biosciences, Inc. | 15 | 2020-07-20 | 2023-01-18 |
| Proof-of-concept Study of LUNA Intervention in Aphasia LUNA - Aphasia, Stroke | Phase 1 | Completed | City, University of London | 28 | 2020-06-14 | 2023-05-06 |
| Intranasal Inhalations of M2 Macrophage Soluble Factors in Children With Developmental Speech Disorders Bioactive Factors, Produced by M2 Type Macrophages (M2-BFs). - Language Delay, Language; Developmental Disorder, Expressive | Phase 1 / Phase 2 | Completed | Russian Academy of Medical Sciences | 14 | 2020-02-01 | 2022-05-02 |
| Intranasal Ketamine and Midazolam Mixture for Procedural Sedation in Children With Mental Disabilities: Ketamine + midazolam - Procedural Sedation | Phase 1 | Unknown | Ain Shams University | 40 | 2019-03-06 | 2019-03-08 |
| Delineation of Sensorimotor Subtypes Underlying Residual Speech Errors Visual-acoustic biofeedback, Ultrasound biofeedback - Speech Sound Disorder | Phase 1 | Completed | New York University | 7 | 2019-03-01 | 2023-12-11 |
| BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES BIIB092, Placebo - Primary Tauopathies, Corticobasal Degeneration Syndrome | Phase 1 | Terminated | University of California, San Francisco | 22 | 2018-09-12 | 2019-12-19 |
| A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia AADvac1 40 µg, AADvac1 160 µg - Primary Progressive Nonfluent Aphasia | Phase 1 | Unknown | Axon Neuroscience SE | 33 | 2017-07-31 | 2019-11-14 |
| Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia F-18 AV 1451 - Primary Progressive Aphasia, Behavioral Variant of Frontotemporal Dementia | Phase 1 | Completed | Mayo Clinic | 81 | 2016-07-01 | 2025-11-21 |
| Evaluating Anodal tDCS Preceding Aphasia Therapy transcranial direct current stimulation - Stroke, Aphasia | Phase 1 / Phase 2 | Terminated | Northwell Health | 15 | 2014-09-01 | 2021-04-05 |
| Brief Behavioral Treatment for Anxiety in Young Children Parent-Led Exposure Therapy, Treatment As Usual - Obsessive-compulsive Disorder, Social Phobia | Phase 1 / Phase 2 | Completed | University of South Florida | 58 | 2014-01-01 | 2016-10-06 |
| Ultrasound Biofeedback for Speech Sound Disorders Ultrasound visual feedback - Speech Sound Disorders | Phase 1 | Completed | Yale University | 35 | 2013-05-01 | 2020-04-03 |
Showing 20 of 39. Sign in to see all of them.
Stroke (11) · Aphasia (8) · Learning Disabilities (7) · Speech (5) · Speech Sound Disorder (5) · Aphasia, Primary Progressive (4) · Language (4) · Language Development Disorders (4) · Primary Progressive Nonfluent Aphasia (4) · Aphasia, Broca (3) · Attention Deficit Disorder with Hyperactivity (3) · Frontotemporal Dementia (3) · Pick Disease of the Brain (3) · Apraxias (2)
Nervous System Diseases (34) · Neurobehavioral Manifestations (34) · Neurologic Manifestations (34) · Pathological Conditions, Signs and Symptoms (34) · Signs and Symptoms (34) · Language Disorders (25) · Mental Disorders (25) · Brain Diseases (21) · Central Nervous System Diseases (21) · Neurodevelopmental Disorders (20) · Speech Disorders (18) · Cardiovascular Diseases (11) · Cerebrovascular Disorders (11) · Vascular Diseases (11)
Transcranial Direct Current Stimulation (3) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (2) · AADvac1 (1) · Acceptance and Commitment Therapy (1) · Animal Assisted Therapy (1) · Anti-Inflammatory Agents (1) · Aripiprazole (1) · Clemastine (1) · Cochlear Implantation (1) · Famotidine (1) · Fecal Microbiota Transplantation (1) · Hearing Aids (1) · Immunomodulation (1) · Ketamine (1) · Levetiracetam (1)
Mayo Clinic (3) · University of California, San Francisco (3) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · New York University (2) · Ain Shams University (1) · AviadoBio Ltd (1) · Axon Neuroscience SE (1) · Black Tie Medical, Inc. (1) · Boston University (1) · Children's Hospitals and Clinics of Minnesota (1) · City, University of London (1) · Climb Up Kids (1) · Governors State University (1) · Kessler Foundation (1) · National Institutes of Health Clinical Center (CC) (1)
United States (31) · United Kingdom (3) · Australia (1) · Belgium (1) · Canada (1) · Egypt (1) · Germany (1) · India (1) · Italy (1) · Netherlands (1) · Poland (1) · Russia (1) · Spain (1) · Sweden (1)
Jonathan Preston, PhD (2) · A.M. Barrett, MD (1) · Achim Klug, PhD (1) · Adam Boxer, MD, PhD (1) · Adam L. Boxer, M.D., Ph.D. (1) · Alexander A Ostanin, MD, PhD (1) · Alvaro Pascual-Leone, M.D., Ph.D. (1) · Audrey Bowen, PhD (1) · Bruce Crosson, PhD (1) · Catherine H Balthazar, PhD (1) · Cheryl M Scott, PhD (1) · Connie Kasari, PhD (1) · Devendra Mehta, MBBS MSC MRCP (1) · Diane L Damiano, Ph.D. (1) · Dwight E Waddell, Ph.D. (1)
PMID 15118944, PMID 15766771, PMID 16006338, PMID 19425468, PMID 19695692, PMID 20145986, PMID 20159655, PMID 20299861, PMID 21794852, PMID 21864891, PMID 23106988, PMID 23280015, PMID 26704258, PMID 29256908, PMID 34232693, PMID 35607935, PMID 38505946, PMID 38875279, PMID 40762274
R01DC017476 (2), 2017 (1), 2023 (1), R01DC005672 (1), R01DC007387 (1), R01DC010075 (1), R01DC020959 (1), R21DC009876 (1), R21DC021249 (1), R21DC021557 (1), R21NS094684 (1), R41NS076123 (1)