37 completed, 19 recruiting, 18 not yet recruiting, 8 unknown. 59 Not applicable, 2 Phase 4, 1 Early Phase 1, 1 Phase 1.
Follow Circadian Rhythm: new trials by email Literature Review of Circadian Rhythm trials Research Report on Circadian Rhythm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep Ocular light exposure from portable light box - Circadian Rhythm, Pupillometry | Not applicable | Not yet recruiting | Elizabeth B Klerman MD PhD | 100 | 2027-09-01 | 2026-09-08 |
| Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain serial whole body hyperthermia - Hyperthermia, Chronic Primary Pain | Not applicable | Not yet recruiting | Bern University of Applied Sciences | 60 | 2026-12-01 | 2026-09-30 |
| HEARTBEAT SOUND FOR BREASTFEEDİNG DİFFİCULTİES: A RANDOMİZED CONTROLLED TRİAL Standardized Maternal Heartbeat Sound Application - Sleep, Circadian Rhythm | Not applicable | Not yet recruiting | Hakan Avan | 80 | 2026-10-25 | 2026-10-19 |
| The Impact of Overnight Active Temperature Regulation on the Gut Microbiome, Inflammation, and Circadian Rhythm. Overnight Active Temperature Regulation: Eight Sleep Pod System - Poor Sleep Quality, Gut Microbiome | Not applicable | Recruiting | Eight Sleep Inc. | 100 | 2026-10-01 | 2026-10-26 |
| Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development Chronobiologically Timed Feeding of Expressed Breast Milk, Usual Feeding Practice (Untimed Expressed Breast Milk) - Infant Sleep Problems, Circadian Rhythm | Not applicable | Not yet recruiting | Luzerner Kantonsspital | 200 | 2026-10-01 | 2026-04-16 |
| Circadian Rhythm and Cardiovascular Recovery After Submaximal Exercise Circadian Rhythm, Health Adult Subjects | Recruiting | Saglik Bilimleri Universitesi | 124 | 2026-10-01 | 2026-10-21 | |
| Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students digital cognitive behavioral therapy for insomnia and digital circadian intervention, digital cognitive behavioral therapy for insomnia, digital health education - Eveningness, Insomnia | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 195 | 2026-09-01 | 2026-09-03 |
| Exercise Interventions in Obstructive Sleep Apnea Syndrome Aerobic Exercise Training, Exercise Snacking - Obstructive Sleep Apnea (OSA), Exercise Snacks | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 39 | 2026-09-01 | 2026-06-08 |
| Dexmedetomidine Trial for Effects on Rhythms, Sleep Architecture, and Biomarker Dynamics in Older Adults Dexmedetomidine sublingual film, Placebo Sublingual Film - Sleep, Circadian Rhythm | Early Phase 1 | Not yet recruiting | Massachusetts General Hospital | 12 | 2026-09-01 | 2026-09-02 |
| Sleep and Circadian Rhythm Intervention in ICU Sound and Light Optimization, Night-time Patient Care Activities, Enhanced Daytime Mobility - ICU Hospitalization, Circadian Rhythm | Not applicable | Recruiting | Shanghai Zhongshan Hospital | 70 | 2026-08-01 | 2026-10-13 |
| Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance Metyrapone And Hydrocortisone, Dextrose, insulin - Shift Work Schedule, Circadian Rhythm | Phase 4 | Recruiting | Washington State University | 48 | 2026-07-16 | 2026-09-18 |
| Circadian Rhythm Monitoring Study Circadian monitoring device - Circadian Rhythm | Not applicable | Not yet recruiting | ResMed | 30 | 2026-07-01 | 2026-05-19 |
| Effect of Circadian Rhythm on the Sedative Efficacy and Recovery Quality of Ciprofol General Anesthesia: A Multi-Center Observational Study Surgery commences in the morning., Surgery commences in the afternoon. - Circadian Rhythm, Ciprofol | Not yet recruiting | Jie Chen | 480 | 2026-06-08 | 2026-07-07 | |
| Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY Continuous glucose monitor (CGM), Wrist actigraphy device, AI-based dietary and meal timing logging mobile application - Continuous Glucose Monitoring, Diabetes, Gestational | Not applicable | Recruiting | KK Women's and Children's Hospital | 140 | 2026-05-01 | 2026-09-15 |
| THE EFFECTS OF CIRCADIAN RHYTHM-BASED PROGRESSIVE RELAXATION EXERCISES IN HEMODIALYSIS PATIENTS Progressive Relaxation Exercises - Nursing, Hemodialysis Patient | Not applicable | Not yet recruiting | Karamanoğlu Mehmetbey University | 75 | 2026-04-01 | 2026-04-08 |
| Effect of Esketamine on Postoperative Sleep in Postmenopausal Women Esketamine, Normal Saline - Circadian Rhythm, Postoperative Sleep Disturbance | Not applicable | Recruiting | Zhuan Zhang | 164 | 2026-03-01 | 2026-08-31 |
| A Longitudinal Follow-Up Study on Predicting Major Depressive Disorder From Rest-Activity Rhythm Profiles Major Depressive Disorder (MDD), Sleep Disorders | Not yet recruiting | Chinese University of Hong Kong | 160 | 2026-02-01 | 2026-02-05 | |
| Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance Circadian Rhythm, Menstrual Cycle Phase | Not yet recruiting | Lancaster University | 30 | 2026-02-01 | 2026-02-10 | |
| Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms High-Intensity Functional Training (HIFT), Supervised Deep Breathing - Exercise Induced Hypoalgesia, Circadian Rhythm | Not applicable | Not yet recruiting | Medipol University | 56 | 2026-01-01 | 2025-12-18 |
| Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients Standard Post-Bariatric Care (Control), Early Time-Restricted Eating (eTRE), Chronotype-Based Chrono-Nutrition (CB-CN) - Obesity (Disorder), Morbid Obesity | Not applicable | Not yet recruiting | King Saud University | 246 | 2026-01-01 | 2026-01-07 |
Showing 20 of 86. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (13) · Motor Activity (5) · Sleep Deprivation (5) · Pain (4) · Chronobiology Disorders (3) · Diabetes Mellitus, Type 2 (3) · Hypertension (3) · Obesity (3) · Sleep Wake Disorders (3) · Alzheimer Disease (2) · Depression (2) · Fatigue (2) · Health Behavior (2) · Inflammation (2) · Parasomnias (2)
Nervous System Diseases (29) · Mental Disorders (25) · Pathological Conditions, Signs and Symptoms (22) · Signs and Symptoms (20) · Sleep Wake Disorders (20) · Dyssomnias (19) · Behavior (15) · Neurologic Manifestations (15) · Sleep Disorders, Intrinsic (15) · Nutritional and Metabolic Diseases (8) · Glucose Metabolism Disorders (6) · Endocrine System Diseases (5) · Metabolic Diseases (5) · Behavioral Symptoms (4) · Body Weight (4)
Caffeine (2) · Ear Protective Devices (2) · Exercise (2) · Light (2) · Melatonin (2) · Propofol (2) · Actigraphy (1) · Diet, Fat-Restricted (1) · Diet, High-Fat (1) · Electroencephalography (1) · Esketamine (1) · Estazolam (1) · Glucose (1) · Health (1) · High-Intensity Interval Training (1)
Brigham and Women's Hospital (6) · Oregon Health and Science University (3) · The First Affiliated Hospital with Nanjing Medical University (3) · China Medical University Hospital (2) · Chinese University of Hong Kong (2) · Leiden University Medical Center (2) · Medipol University (2) · Rush University Medical Center (2) · Shanghai Zhongshan Hospital (2) · The Hong Kong Polytechnic University (2) · The Second Affiliated Hospital of Chongqing Medical University (2) · University of Aarhus (2) · University of Alabama at Birmingham (2) · Assiut University (1) · Baylor College of Medicine (1)
United States (26) · China (10) · Turkey (Türkiye) (9) · Switzerland (6) · Taiwan (4) · Denmark (3) · Hong Kong (3) · Sweden (3) · Netherlands (2) · Austria (1) · Brazil (1) · France (1) · Germany (1) · Greece (1) · Jordan (1)
Xiuqin Wang, doctor (3) · Elizabeth B Klerman, MD PhD (2) · Aimin Wang, MD (1) · Amani A Al-Farraj, Master (1) · Andrew McHill, PhD (1) · Andrew W McHill, PhD (1) · Bill J Duke, M.A., Ph.D. (1) · Brant P Hasler, PhD (1) · Candice A Alfano, PhD (1) · Carolin Reichert, Dr. (1) · Christopher Depner, PhD (1) · Daniel Aeschbach, PhD (1)
PMID 16039739, PMID 21193540, PMID 25208590, PMID 25230376, PMID 25594808, PMID 26785964, PMID 27109818, PMID 29358448, PMID 29452801, PMID 30113379, PMID 30215172, PMID 31334546, PMID 31866308, PMID 33585896, PMID 33633278, PMID 34024173, PMID 35187019, PMID 35470491, PMID 37312021, PMID 38112772, PMID 38165679, PMID 38497216, PMID 39920733, PMID 40300711, PMID 40580209, PMID 40763251, PMID 40950851, PMID 41321483, PMID 41606633, PMID 41607684, PMID 42583379
R01DK102696 (2), 2025 (1), R01AT002129 (1), R01DA061223 (1), R01HD112349 (1), R01HL077399 (1), R01HL177106 (1)