28 completed, 4 recruiting, 3 unknown, 1 active not recruiting. 31 Not applicable, 4 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 31 | Completed 23, Recruiting 4, Unknown 2, Active not recruiting 1, Terminated 1 |
| Phase 1 | 4 | Completed 3, Unknown 1 |
| Phase 2 | 1 | Completed 1 |
Follow Diet, High-Fat: new trials by email Literature Review of Diet, High-Fat trials Research Report on Diet, High-Fat
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Energy Dense Fueling for Cold-Weather Operations High Fat, High Carbohydrate - Cold Exposure | Not applicable | Recruiting | United States Army Research Institute of Environmental Medicine | 8 | 2026-02-14 | 2026-03-24 |
| High Fat Diet for Cardiac Metabolic Reprogramming High fat diet, Standard diet - Non-ischemic Dilated Cardiomyopathy, Heart Failure With Reduced Ejection Fraction | Not applicable | Recruiting | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III | 80 | 2026-01-15 | 2026-05-26 |
| Metabolic Adaptations to High-fat Diet Hypercaloric, High Fat Diet - Adiposity, Insulin Sensitivity | Not applicable | Terminated | George Washington University | 2 | 2024-08-12 | 2025-08-26 |
| FEED-Cystic Fibrosis (FEED-CF) Low-added sugar, high-fat diet, High-added sugar, high-fat CF diet - Cystic Fibrosis, Cystic Fibrosis-related Diabetes | Not applicable | Recruiting | Emory University | 60 | 2023-06-28 | 2026-06-03 |
| Diet Impact on Hepatic Transcriptomics and Lipidomics in Pre-diabetes Low fat diet, High fat diet - Pre-diabetes | Not applicable | Completed | Laval University | 6 | 2023-06-09 | 2026-08-26 |
| Food and Circadian Timing High-Fat Diet, Low-Fat Diet - Diet, High-Fat, Circadian Rhythm | Not applicable | Recruiting | Oregon Health and Science University | 14 | 2022-04-01 | 2026-10-16 |
| Effects of a Chilean Diet Supplemented With Gevuina Avellana on Lipid Profile in Humans With Hypercholesterolemia High-fat diet, Low-fat diet - Hypercholesterolemia | Not applicable | Completed | Universidad de Concepcion | 106 | 2022-03-08 | 2025-07-28 |
| Lean and Obese: Dietary Inflammation Low Fat Diet (LFD), High Fat Diet (HFD) - Obesity, Inflammation | Not applicable | Completed | Rutgers, The State University of New Jersey | 32 | 2022-03-01 | 2026-05-13 |
| N=1 Trials of Individual Variability in Post-prandial Glycemic Responses to Diets of Varying Macronutrient Composition High Protein Diet, High Fat Diet, High Carbohydrate-Low Glycemic Index Diet - Personalized Nutrition | Not applicable | Active not recruiting | National University of Singapore | 120 | 2020-09-03 | 2024-11-15 |
| A Food Effect Study of SHR1459 on Healthy Chinese Adult Subjects SHR1459 fasted in P1, high-fat diet in P2, SHR1459 high-fat diet in P1, fasted in P2 - Healthy Adult Subjects | Phase 1 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 28 | 2020-05-24 | 2020-07-27 |
| The Personalized Nutrition Study High-fat diet, High-carbohydrate diet - Weight Loss | Not applicable | Completed | Pennington Biomedical Research Center | 145 | 2020-02-27 | 2025-01-30 |
| Feasibility of a Carbohydrate-restricted, High-fat Diet on Head and Neck Squamous Cell Carcinoma Outcomes Carbohydrate-restricted, high-fat diet, Regular composition diet - Head and Neck Squamous Cell Carcinoma | Not applicable | Completed | University of Illinois at Urbana-Champaign | 39 | 2020-02-03 | 2021-11-05 |
| The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity High-fat diet, High-carbohydrate diet - Insulin Resistance, Type 2 Diabetes | Not applicable | Unknown | Loughborough University | 20 | 2019-05-22 | 2021-02-24 |
| Effect of Previous Diet High-fat diet, High-residue diet - Healthy | Not applicable | Completed | Hospital Universitari Vall d'Hebron Research Institute | 20 | 2018-10-22 | 2019-05-06 |
| Impact of a High Saturated Fat Diet on Fasted Systemic and White Adipose Tissue Inflammatory Responses High Fat Diet - Inflammation, Obesity | Not applicable | Completed | Loughborough University | 15 | 2018-07-02 | 2019-01-04 |
| High-fat Overfeeding, Hepatokines and Appetite Regulation High-fat diet - Insulin Resistance, Type2 Diabetes Mellitus | Not applicable | Completed | Loughborough University | 12 | 2017-12-11 | 2019-02-18 |
| Characterization of Bile Acid Pathway in Obesity Normal Diet, High Fat Diet, Low Fat Diet - Obesity | Not applicable | Completed | Mayo Clinic | 16 | 2017-11-14 | 2023-04-27 |
| A Clinical Trial to Assess the Effects of Food on the Bioavailability of CKD-337 High fat diet, CKD-337 - Dyslipidemias | Phase 1 | Completed | Chong Kun Dang Pharmaceutical | 16 | 2017-10-12 | 2017-12-27 |
| Gut Microbiome Based Analysis of High Protein High Fat Diet High fat diet - Obesity | Not applicable | Completed | Center of Food and Fermentation Technologies | 78 | 2017-04-01 | 2020-12-23 |
| "ADAPT" The Adaptation to High Fat Diets Extention High Fat Diet, Low Fat Diet - Healthy | Not applicable | Completed | Pennington Biomedical Research Center | 72 | 2016-07-01 | 2022-09-15 |
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Obesity (8) · Insulin Resistance (7) · Glucose Intolerance (3) · Cardiovascular Diseases (2) · Diabetes Mellitus, Type 2 (2) · Dyslipidemias (2) · Inflammation (2) · Weight Loss (2) · Body Weight Changes (1) · Breast Neoplasms (1) · Cystic Fibrosis (1) · Glucose Metabolism Disorders (1) · Heart Failure (1) · Hypercholesterolemia (1) · Kidney Failure, Chronic (1)
Loughborough University (3) · Jiangsu HengRui Medicine Co., Ltd. (2) · Laval University (2) · Oregon Health and Science University (2) · Pennington Biomedical Research Center (2) · Center of Food and Fermentation Technologies (1) · Chong Kun Dang Pharmaceutical (1) · Christiana Care Health Services (1) · Emory University (1) · Enzychem Lifesciences Corporation (1) · Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (1) · George Washington University (1) · Göteborg University (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · James Lewis (1)
United States (16) · United Kingdom (4) · China (3) · Canada (2) · France (2) · South Korea (2) · Spain (2) · Chile (1) · Estonia (1) · Italy (1) · Palestinian Territories (1) · Romania (1) · Singapore (1) · Sweden (1)
Andres J Acosta Cardenas (1) · Andrew McHill, PhD (1) · Anna E Arthur, PhD, MPH (1) · Bente Kiens, Professor (1) · Carl Hulston, PhD (1) · Elizabeth J Parks, PhD (1) · Francesco Sofi, MD PhD (1) · Gareth A Wallis, PhD (1) · James A King, PhD (1) · James D Lewis, MD, MSCE (1) · James Hays, MD (1) · Jeffrey F Horowitz, Ph.D. (1)
PMID 19228873, PMID 21252253, PMID 21745038, PMID 23719552, PMID 24500151, PMID 27173380, PMID 28655596, PMID 29392797, PMID 30782617, PMID 30876827, PMID 31919514, PMID 32232380, PMID 35565929, PMID 37813841, PMID 39725418, PMID 40480607, PMID 41542842, PMID 41791910
2019 (1), K23DK114460 (1), R01DK133523 (1), UH2DK083981 (1)