59 completed, 20 recruiting, 15 unknown, 8 not yet recruiting. 75 Not applicable, 10 Phase 3, 10 Phase 4, 5 Phase 2, 2 Phase 1.
Follow Chronic Insomnia: new trials by email Literature Review of Chronic Insomnia trials Research Report on Chronic Insomnia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Shiwei Anshen Granules for Chronic Insomnia Shiwei Anshen granules, Placebo granules - Chronic Insomnia | Not applicable | Not yet recruiting | Dongzhimen Hospital, Beijing | 240 | 2026-11-01 | 2026-10-26 |
| Effects of Connective Tissue Massage in Patients With Chronic Insomnia Connective Tissue Massage, Sleep Hygiene Education - Chronic Insomnia | Not applicable | Not yet recruiting | Saglik Bilimleri Universitesi | 74 | 2026-09-01 | 2026-08-18 |
| Transcranial Temporal Interference Stimulation (tTIS) for Chronic Insomnia Active Transcranial Temporal Interference Stimulation (tTIS)-Experimental, Sham Transcranial Temporal Interference Stimulation (tTIS)-Sham Comparator - Chronic Insomnia | Not applicable | Not yet recruiting | Ruijin Hospital | 30 | 2026-08-30 | 2026-08-10 |
| Cognitive Behavioral Therapy for Insomnia as an Adjunct to Time-restricted Eating on Weight Loss in Adults With Overweight or Obesity and Chronic Insomnia Flexible Time-restricted eating group (FTRE), Flexible Time-restricted eating plus cognitive behavioural therapy for insomnia group (CBTI+FTRE) - Chronic Insomnia, Overweight/Obesity | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 50 | 2026-08-25 | 2026-08-18 |
| Effects of Accelerated rTMS on Sleep Architecture in Chronic Insomnia Disorder TMS - Insomnia, Chronic Insomnia | Not applicable | Enrolling by invitation | San Francisco Neurology and Sleep Center | 70 | 2026-08-05 | 2026-08-13 |
| PREDiction of Different Variants of Sleep Stages for the Diagnosis Support of Chronic Insomnia and Epilepsy Chronic Insomnia, Epilepsy | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1500 | 2026-06-01 | 2026-04-29 | |
| A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia Sleep Hygiene Education, Melatonin IR, 3 mg, Melatonin IR, 5 mg - Insomnia, Insomnia Disorder | Phase 4 | Recruiting | University of Pennsylvania | 1200 | 2026-05-01 | 2026-09-16 |
| Implementing Cognitive Behavioral Therapy for Insomnia (SWELL): Function QUERI 3.0 Implementation Strategy: Foundational Arm, Implementation Strategy: REACH arm - Chronic Insomnia | Not applicable | Recruiting | VA Office of Research and Development | 20 | 2026-04-30 | 2026-05-07 |
| Internet-Based Cognitive Behavioral Therapy for Insomnia in Persian-Speaking Adults Omid Internet-Based CBT-I Program - Insomnia Disorder, Chronic Insomnia | Not applicable | Completed | Rasool Hamidi Choolabi | 30 | 2026-02-21 | 2026-08-19 |
| Facial Emotion Recognition in Insomnia and Emotional Regulation Facial emotion recognition test with and without eye-tracking and Cognitive Emotion Regulation. Questionnaire (CERQ) - Chronic Insomnia | Not applicable | Recruiting | University Hospital, Angers | 128 | 2025-12-12 | 2026-04-06 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Evaluation of the Efficacy of E2R Hypnotherapy in the Management of Chronic Insomnia in Primary Care (HypERR) "Standard care" control group (without hypnosis), Experimental group: "E2R hypnosis" - Chronic Insomnia | Not applicable | Recruiting | Rennes University Hospital | 136 | 2025-10-14 | 2026-08-19 |
| Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling. - Chronic Low Back Pain (CLBP), Chronic Insomnia | Recruiting | Vrije Universiteit Brussel | 80 | 2025-10-03 | 2025-12-15 | |
| Restorative Effects of Sleep on Everyday Health and Wellbeing: A Treatment Study Cognitive Behavioral Therapy for Insomnia - Chronic Insomnia | Not applicable | Recruiting | University of Notre Dame | 115 | 2025-09-29 | 2026-04-23 |
| Exploration of the Effectiveness of Vibrational Intervention in Improving Insomnia Symptoms Vibrational stimulation, Sham - Chronic Insomnia | Not applicable | Recruiting | Jia Xiu | 120 | 2025-09-01 | 2025-09-19 |
| Transcranial Alternating Current Stimulation for Generalized Anxiety Disorder and Insomnia: An Open-Label Pilot Study Transcranial Alternating Current Stimulation (tACS) - Generalized Anxiety Disorder (GAD), Chronic Insomnia | Not applicable | Recruiting | University of Sao Paulo | 30 | 2025-06-01 | 2026-06-23 |
| Brief Trial of ACT-i for Adults With Chronic Insomnia Acceptance and Commitment Therapy for Insomnia, Attentional Control Group - Chronic Insomnia | Not applicable | Recruiting | Babes-Bolyai University | 76 | 2025-05-23 | 2026-09-25 |
| A Randomized, Single-Blind Study Evaluating the Efficacy and Cost-Effectiveness of Brief Behavioral Therapy for Chronic Insomnia Patients Under Medication Treatment At Nguyen Trai Hospital, Ho Chi Minh City BBT-I, Non BBT-I - Chronic Insomnia Disorder, Chronic Insomnia | Not applicable | Not yet recruiting | Nguyen Trai Hospital | 100 | 2024-12-15 | 2024-12-11 |
| Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain CBT-I, Treatment as usual, Tapered Withdrawal - Chronic Pain, Chronic Insomnia | Not applicable | Recruiting | University of South Florida | 165 | 2024-12-11 | 2026-04-21 |
| Effects of Sleep Restriction and Stimulus Control in Chronic Insomnia Patients sleep restriction and stimulus control, sleep hygiene education - Chronic Insomnia | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 88 | 2024-12-01 | 2025-05-09 |
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Sleep Initiation and Maintenance Disorders (111) · Sleep Wake Disorders (13) · Chronic Pain (6) · Anxiety Disorders (5) · Depression (5) · Motor Activity (4) · Pain (4) · Neoplasms (3) · Stress Disorders, Post-Traumatic (3) · Alzheimer Disease (2) · Fatigue (2) · Parasomnias (2) · Sleep Deprivation (2) · Sleep Disorders, Circadian Rhythm (2) · Anemia (1)
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ramelteon (14) · Cognitive Behavioral Therapy (13) · Zolpidem (4) · Eszopiclone (2) · Exercise (2) · Tai Ji (2) · Therapeutics (2) · Transcranial Direct Current Stimulation (2) · Trazodone (2) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (1) · Acupuncture Therapy (1) · Administration, Sublingual (1) · Behavior Therapy (1) · Blood Specimen Collection (1) · Clonidine (1)
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Xiuqin Wang, doctor (2) · Abby Doctolero (1) · Adam D. Bramoweth, PhD (1) · Anne Germain (1) · Anne Germain, PhD (1) · Anne Germain, PhD. (1) · Babak Mokhlesi, MD (1) · Benjamin Putois, MD, Ph.D (1) · Britani Holland, PhD (1) · Bruce Rybarczyk, PhD (1) · Charles M. Morin, PhD (1) · Cheng Zhang, Doctor (1) · Cheryl Harris (1)
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1IK2HX001548-01A2 (1), 2004 (1), 2019 (1), KL2TR002317 (1), R01DA054311 (1), R01NR016191 (1), R01NR018215 (1), R15NR013779 (1)