15 completed, 7 unknown, 6 recruiting, 5 not yet recruiting. 35 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 35 | Completed 15, Unknown 7, Recruiting 6, Not yet recruiting 5, Terminated 2 |
Follow Chronic Cough: new trials by email Literature Review of Chronic Cough trials Research Report on Chronic Cough
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chronic COUGH Management in Interstitial Lung DisEase Non-pharmacological cough control therapy, Healthy lifestyle - Interstitial Lung Disease, Chronic Cough | Not applicable | Not yet recruiting | Aveiro University | 60 | 2027-12-20 | 2025-01-20 |
| Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection - Postoperative Cough, Cough Hypersensitivity Syndrome | Not applicable | Not yet recruiting | Tongji Hospital | 248 | 2026-09-01 | 2026-05-07 |
| Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough Acceptance and Commitment Therapy (ACT) - Chronic Cough | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 30 | 2026-08-01 | 2026-05-06 |
| Efficacy of Behavioral Therapy for Chronic Refractory Cough Behavioral Therapy - Chronic Cough | Not applicable | Recruiting | Assiut University | 30 | 2026-03-10 | 2026-04-23 |
| Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance High resolution oesophageal manometry with impedance, 24-hour pH metry - Extraesophageal Reflux, Laryngopharyngeal Reflux | Not applicable | Not yet recruiting | University Hospital Ostrava | 160 | 2026-01-01 | 2026-01-23 |
| A Prospective, Randomized, Double-blind Study on the Effects of Different Anesthesia Strategies on Postoperative Cough in Patients Undergoing Video-assisted Thoracoscopic Surgery. Patients were randomly grouped - Chronic Cough, Video-assisted Thoracoscopic Surgery (VATS) | Not applicable | Not yet recruiting | Fujian Medical University Union Hospital | 228 | 2025-10-01 | 2025-09-24 |
| Sputum Cytometry Guided Management for the Elimination of Chronic Cough in Patients With ILD Sputum-guided management, Standard of Care - ILD | Not applicable | Recruiting | McMaster University | 120 | 2025-05-22 | 2026-10-07 |
| Cough Management Wellness App for Refractory or Unexplained Chronic Cough Cough Management, CoughMonitor Suite - Refractory Chronic Cough, Unexplained Chronic Cough | Not applicable | Recruiting | Hyfe Inc | 20 | 2025-03-27 | 2025-09-11 |
| Study to Investigate the Efficacy and Safety of SC0023, in Adults With Refractory or Unexplained Chronic Cough oral spray of MgCl2, Saline - Chronic Cough | Not applicable | Completed | Kholood Altassan | 7 | 2024-12-19 | 2026-01-21 |
| The Real-world Treatment Satisfaction by Gefapixiant in RCC Gefapixant Citrate - Chronic Cough | Not applicable | Recruiting | Nagoya City University | 63 | 2024-12-04 | 2025-01-29 |
| Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung Resection Vagus Nerve Pulmonary Branch Block, Vagus Nerve Pulmonary Branch Injection - Postoperative Cough, Thoracoscopy | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 104 | 2024-07-15 | 2024-07-29 |
| Single-center Clinical Study on the Safety and Effect of Bronchoscopic Cryotherapy in Patients With Chronic Cough General treatment, Cryotherapy Treatment - Chronic Cough | Not applicable | Unknown | Guangzhou Medical University | 20 | 2024-04-01 | 2024-04-25 |
| Internet-Behavioral Cough Suppression Therapy Internet-Behavioral Cough Suppression Therapy, Sham Treatment - Cough, Chronic Disease | Not applicable | Completed | University of Montana | 39 | 2023-07-01 | 2025-06-05 |
| Biomarkers for Predicting the Response to Inhaled Corticosteroid in Patients With Chronic Cough. Beclometasone Dipropionate and Formoterol Inhalation Aerosol, Placebo - Cough | Not applicable | Completed | The First Affiliated Hospital of Guangzhou Medical University | 502 | 2023-04-01 | 2026-02-18 |
| Validation Study With a Non-CE Marked Medical Device (MD) SIVA-MVP - Chronic Cough | Not applicable | Completed | Siva Health AG | 50 | 2023-03-02 | 2025-05-15 |
| ATP and P2X3 Receptor in Chronic Cough Adenosine triphosphate (ATP) solution inhalation from nebuliser, Inhalational challenge with increasing concentrations of capsaicin solutions, Recording of Cough Count and frequency using the Hyfe Cough Monitor - Cough | Not applicable | Unknown | Imperial College London | 20 | 2023-02-28 | 2023-02-06 |
| Cough Suppressive Therapy in Patients With Chronic Cough Cough suppressive therapy, General healthy lifestyle instructions - Chronic Cough | Not applicable | Unknown | Uppsala University | 100 | 2022-11-03 | 2022-11-08 |
| Inhaled vs Intranasal Corticosteroids for Chronic Cough in Upper Airway Cough Syndrome Budesonide (400μg/d), Mometasone Furoate 50mcg Nasal Spray - Chronic Cough (CC), Upper Airway Cough Syndrome | Not applicable | Completed | Silesian University of Medicine | 56 | 2022-07-01 | 2026-09-16 |
| Chronic Cough and Small Fiber Neuropathy Cough assessment, Neurological tests and cardiovascular tests, Skin biopsy - Chronic Cough, Type 2 Diabetes | Not applicable | Terminated | University Hospital, Toulouse | 7 | 2022-06-14 | 2026-06-01 |
| Study of AffloVest in At-Risk Respiratory Patients During COVID-19 Pandemic HCFWO, Standard Care Plus Monitoring - Chronic Obstructive Pulmonary Disease, Chronic Cough | Not applicable | Terminated | Icahn School of Medicine at Mount Sinai | 1 | 2021-07-20 | 2022-05-05 |
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Cough (13) · Gastroesophageal Reflux (2) · Laryngopharyngeal Reflux (2) · Lung Diseases (2) · cough hypersensitivity syndrome (2) · Asthma (1) · Bronchial Hyperreactivity (1) · COVID-19 (1) · Chronic Disease (1) · Communication Disorders (1) · Cough-Variant Asthma (1) · Deglutition Disorders (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1)
Pathological Conditions, Signs and Symptoms (35) · Respiration Disorders (35) · Respiratory Tract Diseases (35) · Signs and Symptoms (35) · Signs and Symptoms, Respiratory (35) · Cough (22) · Digestive System Diseases (4) · Esophageal Diseases (4) · Esophageal Motility Disorders (4) · Gastrointestinal Diseases (4) · Bronchial Diseases (3) · Deglutition Disorders (3) · Lung Diseases (3) · Lung Diseases, Obstructive (3) · Nervous System Diseases (3)
Standard of Care (2) · Acceptance and Commitment Therapy (1) · Beclomethasone (1) · Behavior Therapy (1) · Budesonide (1) · Chest Wall Oscillation (1) · Electric Impedance (1) · Fractional Exhaled Nitric Oxide Testing (1) · Ketamine (1) · Mannitol (1) · Mometasone Furoate (1) · Nasal Sprays (1) · Speech Therapy (1)
University Hospital Ostrava (2) · Assistance Publique Hopitaux De Marseille (1) · Assiut University (1) · Aveiro University (1) · Azienda Ospedaliera Universitaria Policlinico "G. Martino" (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Evoleen AG (1) · Federico II University (1) · Fujian Medical University Union Hospital (1) · Guangzhou Medical University (1) · Hyfe Inc (1) · Icahn School of Medicine at Mount Sinai (1) · Imperial College London (1) · Jacky Smith (1) · Kholood Altassan (1)
United States (7) · China (5) · France (3) · Canada (2) · Czechia (2) · Italy (2) · Poland (2) · Egypt (1) · Finland (1) · Japan (1) · Portugal (1) · Saudi Arabia (1) · South Korea (1) · Sweden (1) · Switzerland (1)
Annamaria Staiano (1) · Carolyn Novaleski, Ph.D., CCC-SLP (1) · Christian Clarenbach, PhD. Dr. med. (1) · Eman Sayed Hassan, Professor (1) · Gioacchino Calapai, MD (1) · Heikki O Koskela, MD (1) · Helen Wallstedt (1) · Jane Reynolds, PhD (1) · Kefang Lai, phD (1) · Kian Fan Chung, MD (1) · Krishna Sundar, MD (1) · Laurent Guilleminault, MD (1)
PMID 25079477, PMID 26426314, PMID 29016626, PMID 32356074, PMID 33430841, PMID 41020184
2023 (1), K23HL169934 (1), R34HL174877 (1)