12 completed, 4 recruiting, 4 unknown, 3 not yet recruiting. 15 Not applicable, 3 Phase 3, 2 Phase 1, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 15 | Completed 7, Unknown 4, Recruiting 3, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 1, Recruiting 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow Chronic Anal Fissure: new trials by email Literature Review of Chronic Anal Fissure trials Research Report on Chronic Anal Fissure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| Female Sexual Function After Surgery for Benign Perianal Diseases Surgical Treatment for Benign Perianal Diseases - Chronic Anal Fissure, Hemorrhoidal Disease | Not yet recruiting | Gazi University | 120 | 2026-08-01 | 2026-06-26 | |
| AI-Assisted Written Information in Chronic Anal Fissure AI-assisted written patient information, Standardized verbal counseling - Chronic Anal Fissure | Not applicable | Recruiting | Sanliurfa Education and Research Hospital | 220 | 2026-07-15 | 2026-09-09 |
| Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal Fissure Topical 0.2% Glyceryl Trinitrate (Nitroglycerin) Ointment, Lateral Internal Sphincterotomy - Chronic Anal Fissure | Not applicable | Completed | Sheikh Zayed Federal Postgraduate Medical Institute | 72 | 2026-06-15 | 2026-10-21 |
| Comparison of Lateral Internal Sphincterotomy Techniques for Chronic Anal Fissure Spasm-Controlled Lateral Internal Sphincterotomy, Lateral Internal Sphincterotomy up to Fissure Apex, Lateral Internal Sphincterotomy up to Dentate Line - Chronic Anal Fissure | Not applicable | Recruiting | Çanakkale Onsekiz Mart University | 150 | 2026-05-06 | 2026-05-14 |
| RELIEF Study: Resolving Fissures With Lateral Internal Sphincterotomy Lateral Internal Sphincterotomy (LIS) - Chronic Anal Fissure | Not yet recruiting | Turkish Society of Colon and Rectal Surgery | 300 | 2025-06-01 | 2025-05-22 | |
| E-CEL UVEC Treatment for Anal Fissures E-CEL UVEC cells (AB-207) - Chronic Anal Fissure | Phase 1 | Recruiting | Weill Medical College of Cornell University | 20 | 2024-09-12 | 2026-04-08 |
| Combined Method of Surgical Treatment of Anal Fissure excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A - Chronic Anal Fissure | Not applicable | Recruiting | State Scientific Centre of Coloproctology, Russian Federation | 122 | 2023-09-01 | 2025-12-05 |
| Low Versus High Dose OnabotulinumtoxinA for Chronic Anal Fissure OnabotulinumtoxinA - Chronic Anal Fissure | Completed | Tanta University | 150 | 2023-08-01 | 2026-10-28 | |
| Botulinum Toxin Type A in the Treatment of Chronic Anal Fissure Botulinum toxin type A - Chronic Anal Fissure | Not applicable | Unknown | State Scientific Centre of Coloproctology, Russian Federation | 140 | 2022-09-01 | 2022-10-28 |
| Surgical Treatment of a Chronic Anal Fissure lateral subcutaneous sphincterotomy - Chronic Anal Fissure | Not applicable | Unknown | State Scientific Centre of Coloproctology, Russian Federation | 120 | 2021-11-01 | 2021-11-11 |
| Effect of Shock Waves Therapy on Chronic Anal Fissure shock master (shock waves device) - Chronic Anal Fissure | Not applicable | Unknown | amr bayoumi salama | 20 | 2021-03-10 | 2021-03-11 |
| Postero-lateral Internal Sphincterotomy vs Botulinum Toxin Injection in the Treatment of Chronic Anal Fissure Botulinum Toxins, Posterolateral internal sphincterotomy - Chronic Anal Fissure | Not applicable | Unknown | Mansoura University | 60 | 2019-05-01 | 2020-05-29 |
| Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal Fissure Closed Lateral Internal Sphincterotomy, Open Lateral Internal Sphincterotomy - Chronic Anal Fissure | Not applicable | Completed | Services Hospital, Lahore | 160 | 2019-02-01 | 2026-03-27 |
| High Dose Multiple Site Injection of Botox Versus Lateral Sphincterotomy in Chronic Analfissure botox injection in intersphincteric space, lateral internal sphincterotomy - Chronic Anal Fissure | Not applicable | Completed | Zagazig University | 96 | 2017-06-01 | 2019-11-21 |
| The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure Nifedipine - Chronic Anal Fissure | Phase 2 / Phase 3 | Completed | RDD Pharma Ltd | 339 | 2016-05-01 | 2018-10-23 |
| Treatment Of Chronic Anal Fissure Levorag Emulgel, Diltiazem - Chronic Anal Fissure | Not applicable | Terminated | Bispebjerg Hospital | 55 | 2014-09-01 | 2020-01-14 |
| Percutaneous Tibial Nerve Stimulation - an Alternative Treatment Option for Chronic Therapy Resistant Anal Fissure Percutaneous tibial nerve stimulation - Chronic Anal Fissure | Not applicable | Completed | Region Skane | 10 | 2013-09-30 | 2018-09-13 |
| Transcutaneous Posterior Tibial Nerve Stimulation for Treatment of Chronic Anal Fissure lateral internal sphincterotomy, TENS - Chronic Anal Fissure | Not applicable | Completed | Mansoura University | 94 | 2012-07-01 | 2015-03-24 |
| Outcomes of the Use of CO2 (Carbon Dioxide) Laser in the Treatment of Chronic Anal Fissure Laser surgery - Chronic Anal Fissure | Not applicable | Completed | University of Nineveh | 236 | 2012-01-14 | 2019-03-13 |
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Fissure in Ano (7) · Fecal Incontinence (4) · Calciphylaxis (1) · Colitis, Ulcerative (1) · Craniocerebral Trauma (1) · Crohn Disease (1) · Enterocolitis, Pseudomembranous (1) · Epidermolysis Bullosa (1) · Frostbite (1) · Graft vs Host Disease (1) · Hypospadias (1) · Invasive Fungal Infections (1) · Multiple Sclerosis (1) · Myositis, Inclusion Body (1) · Optic Neuropathy, Ischemic (1)
Digestive System Diseases (10) · Gastrointestinal Diseases (10) · Intestinal Diseases (10) · Rectal Diseases (10) · Anus Diseases (7) · Neurologic Manifestations (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Arterial Occlusive Diseases (1) · Autoimmune Diseases (1) · Autoimmune Diseases of the Nervous System (1) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Behavior (1) · Bone Diseases (1)
Botulinum Toxins, Type A (4) · Lateral Internal Sphincterotomy (4) · Diltiazem (2) · Nitroglycerin (2) · Ointments (2) · Botulinum Toxins (1) · Laser Therapy (1) · Levorag (1) · Nifedipine (1) · Oxygen (1) · Surgical Procedures, Operative (1) · Transcutaneous Electric Nerve Stimulation (1) · gene 11 protein, Rotavirus B (1)
Mansoura University (3) · State Scientific Centre of Coloproctology, Russian Federation (3) · RDD Pharma Ltd (2) · Bispebjerg Hospital (1) · Gazi University (1) · Hospital General Universitario Elche (1) · Jay C. Buckey Jr. (1) · Region Skane (1) · S.L.A. Pharma AG (1) · Sanliurfa Education and Research Hospital (1) · Services Hospital, Lahore (1) · Sheikh Zayed Federal Postgraduate Medical Institute (1) · Tanta University (1) · Turkish Society of Colon and Rectal Surgery (1) · University of Nineveh (1)
Egypt (5) · Russia (3) · Bulgaria (2) · Pakistan (2) · Romania (2) · Spain (2) · Turkey (Türkiye) (2) · Denmark (1) · Germany (1) · Israel (1) · Lithuania (1) · Moldova (1) · Poland (1) · United Kingdom (1) · United States (1)
Andreas Nordholm-Carstensen, MD (1) · Antonio Arroyo, PhD (1) · Awais Amjad Malik, MBBS, FCPS (1) · Bengt Jeppsson, Professor (1) · Chris Jordan, PhD (1) · Jay Buckey (1) · Kelly Garrett, MD (1) · Mostafa Shalaby (1) · Peter-Martin Krarup, MD (1) · Sergey A. Frolov, Ph.D (1) · Sergey A. Frolov, Ph.D. (1)
PMID 10782451, PMID 15711861, PMID 17665247, PMID 18085337, PMID 19225835, PMID 20177691, PMID 20940607, PMID 22810476, PMID 26316154, PMID 31980871, PMID 38712744, PMID 9407982