21 completed, 9 unknown, 8 recruiting, 4 terminated. 11 Not applicable, 7 Phase 2, 6 Phase 1, 5 Phase 3, 5 Phase 4.
Follow this condition Literature Review of Optic Neuropathy, Ischemic trials Research Report on Optic Neuropathy, Ischemic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| NAION in Non-Diabetic Obese Patients Using GLP-1 Receptor Agonists: A Real-World Study GLP-1 Receptor Agonist Therapy - Non-arteritic Anterior Ischemic Optic Neuropathy Obesity, Obesity | Not yet recruiting | Istanbul Saglik Bilimleri University | 28 | 2026-09-21 | 2026-09-29 | |
| Effects of Different MAP Targets on Ocular Perfusion and Optic Nerve Microvasculature During Rhinoplasty Lower MAP Target Strategy (50-60 mmHg), Higher MAP Target Strategy (60-70 mmHg) - Controlled Hypotension for Nasal Surgeries | Not applicable | Recruiting | Hitit University | 60 | 2026-09-20 | 2026-10-14 |
| Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Cenegermin, Vehicle - Non-Arteritic Anterior Ischemic Optic Neuropathy | Phase 3 | Recruiting | Dompé Farmaceutici S.p.A | 272 | 2026-07-01 | 2026-09-10 |
| Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell Arteritis Positron Emission Tomography / Magnetic Resonance Imaging - Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy | Recruiting | Copenhagen University Hospital, Rigshospitalet | 122 | 2026-01-14 | 2026-05-07 | |
| Optic Nerve Head Evaluation Through Multimodal Blood Flow Analysis: a Prospective Observational, Multi-center Study Neuro-Ophthalmology, Optic Neuropathies | Not yet recruiting | Barboni | 70 | 2025-10-01 | 2025-07-20 | |
| Optic Nerve Sheath Ultrasound in Giant Cell Arteritis Optic nerve sheath ultrasound, Standardized GCA assessment - Giant Cell Arteritis, Anterior Ischemic Optic Neuropathy | Recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 285 | 2025-08-09 | 2026-10-21 | |
| Optic Nerve Injury in Obstructive Sleep Apnea Patients CPAP Treatment - Obstructive Sleep Apnea (OSA), Ischemic Optic Neuropathy/Optic Nerve Stroke | Not applicable | Recruiting | Nanjing Medical University | 80 | 2025-01-01 | 2025-06-27 |
| Visual Involvement in Giant Cell Arteritis Fluorescein and Indocyanine green Angiography, High-resolution Optical Coherence Tomography, Angio-Optical Coherence Tomography - Giant Cell Arteritis, Visual Impairment | Recruiting | ASST Fatebenefratelli Sacco | 762 | 2024-06-27 | 2024-07-15 | |
| Building Research With Artificial Intelligence in Neuro-Ophthalmology Deep learning algorithm applied on retrospectively collected color fundus photographs - Optic Neuropathy, Optic Neuropathy, Ischemic | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 693 | 2023-10-01 | 2025-09-08 | |
| Platelet-Rich Plasma for Acute Nonarteritic Anterior Ischemic Optic Neuropathy: A Prospective Randomized Controlled Study Autologous Platelet-Rich Plasma (PRP) - Nonarteritic Anterior Ischemic Optic Neuropathy | Not applicable | Completed | Uludag University | 31 | 2022-01-01 | 2026-01-09 |
| Safety and Tolerability of NTX-101 in Korean Healthy Volunteers NTX-101, Placebo - Healthy Volunteers | Phase 1 | Completed | Pinotbio, Inc. | 36 | 2021-03-02 | 2022-04-20 |
| Efficacy of Tocilizumab for the Treatment of Acute AION Related to GCA tocilizumab and IV steroids combination, IV steroids combination alone - Giant Cell Arteritis, Optic Ischaemic Neuropathy | Phase 2 | Unknown | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | 58 | 2020-09-10 | 2022-03-18 |
| Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy. Neuroimaging, VEP - visual evoked potential, Ophthalmology examination. - Ischemic Optic Neuropathy, Optic Neuritis | Not applicable | Unknown | Medical University of Bialystok | 20 | 2020-01-01 | 2022-04-29 |
| New Non-invasive Modalities for Assessing Retinal Structure and Function LSFG-NAVI - Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion | Not applicable | Recruiting | Randy Kardon | 500 | 2019-05-06 | 2026-09-08 |
| Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) RPh201 Cohort A, Placebo Cohort A, RPh201 Cohort B - Nonarteritic Anterior Ischemic Optic Neuropathy | Phase 2 | Terminated | Regenera Pharma Ltd | 165 | 2018-07-10 | 2020-10-12 |
| Intravenous Infusion of Prostaglandins as Therapy in Patients With Anterior Non-arteritic Ischemic Optic Neuropathy Alprostadil 20 micrograms, Placebo - Ischemic Optic Neuropathy | Phase 2 | Unknown | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | 24 | 2018-06-13 | 2019-02-25 |
| Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Dynamic Vessel Analyzer (DVA), Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Optical coherence tomography (OCT) - Anterior Ischemic Optic Neuropathy | Not applicable | Completed | Medical University of Vienna | 1 | 2018-06-11 | 2021-09-01 |
| Biomechanics of Optic Neuropathy magnetic resonance image (MRI), Optical Coherence Tomography (OCT) - Optic Neuropathy | Terminated | University of Miami | 10 | 2016-09-01 | 2020-10-23 | |
| Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) QPI-1007 Injection - 1.5 mg, QPI-1007 Injection - 3.0 mg, Sham Injection Procedure - Non Arteritic Anterior Ischemic Optic Neuropathy | Phase 2 / Phase 3 | Terminated | Quark Pharmaceuticals | 732 | 2016-02-24 | 2020-07-20 |
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Optic Nerve Diseases (12) · Blindness (5) · Glaucoma (5) · Optic Atrophy, Hereditary, Leber (5) · Giant Cell Arteritis (4) · Optic Atrophy (4) · Optic Nerve Injuries (4) · Optic Neuritis (4) · Vision Disorders (4) · Eye Diseases (3) · Retinal Artery Occlusion (3) · Retinal Diseases (3) · Cone Dystrophy (2) · Cone-Rod Dystrophies (2)
Cardiovascular Diseases (46) · Cranial Nerve Diseases (46) · Nervous System Diseases (46) · Vascular Diseases (46) · Eye Diseases (43) · Optic Nerve Diseases (34) · Pathological Conditions, Signs and Symptoms (12) · Signs and Symptoms (9) · Autoimmune Diseases (8) · Autoimmune Diseases of the Nervous System (8) · Immune System Diseases (8) · Neurologic Manifestations (8) · Sensation Disorders (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Genetic Diseases, Inborn (7)
Tomography, Optical Coherence (3) · Magnetic Resonance Imaging (2) · Propofol (2) · 4-Aminopyridine (1) · Aspirin (1) · Bosentan (1) · Continuous Positive Airway Pressure (1) · Cottonseed Oil (1) · Cytidine Diphosphate Choline (1) · Desflurane (1) · Immunoglobulins, Intravenous (1) · Jupiter (1) · Neuroimaging (1) · Oxygen (1) · Phosphodiesterase 5 Inhibitors (1)
MD Stem Cells (2) · National Eye Institute (NEI) (2) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (2) · Quark Pharmaceuticals (2) · Regenera Pharma Ltd (2) · Rutgers, The State University of New Jersey (2) · Shahid Beheshti University of Medical Sciences (2) · ASST Fatebenefratelli Sacco (1) · Barboni (1) · Bayer (1) · Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (1) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dompé Farmaceutici S.p.A (1) · Eli Lilly and Company (1)
United States (19) · Canada (5) · France (4) · Italy (4) · Australia (3) · China (3) · Israel (3) · Turkey (Türkiye) (3) · Austria (2) · Germany (2) · Iran (2) · Spain (2) · United Kingdom (2) · Denmark (1) · India (1)
Geordie P. Grant, MD (2) · Jeffrey Weiss, MD (2) · Steven Levy, MD (2) · Alessandro Invernizzi, Prof. (1) · Amit Chopra, M.D. (1) · Byron R Lam, MD (1) · Edward Margolin (1) · Emmanuel Heron, MD (1) · Jay Buckey (1)
PMID 26199618, PMID 26604914, PMID 27857759, PMID 27904503, PMID 16249960, PMID 25358826, PMID 29270420, PMID 30050918, PMID 30194931, PMID 31119146, PMID 31620478, PMID 32039263, PMID 32231088, PMID 32568958, PMID 33546345, PMID 36309759, PMID 36700417, PMID 40576025, PMID 42155674
2014 (1), 2019 (1)