7 completed, 7 recruiting, 3 not yet recruiting, 2 terminated. 4 Phase 3, 3 Phase 1, 2 Not applicable, 2 Phase 2, 1 Early Phase 1.
Follow Calciphylaxis: new trials by email Literature Review of Calciphylaxis trials Research Report on Calciphylaxis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Anti-Interleukin-6 (IL6) in Calciphylaxis Tocilizumab - Calciphylaxis | Phase 1 | Not yet recruiting | Boston Medical Center | 10 | 2027-09-01 | 2026-07-16 |
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| Study of EPN-701 for the Treatment of Calciphylaxis EPN-701 (Oral), Placebo (Normal Saline) - Calciphylaxis | Phase 2 | Not yet recruiting | Sagar U. Nigwekar, MD, MMSc | 60 | 2026-10-01 | 2026-09-14 |
| Calciphylaxis in Patients With Chronic Kidney Disease - A Study of the Danish Calciphylaxis Research Initiative (DanCaRI) Calciphylaxis, Calcific Uremic Arteriolopathy | Recruiting | Odense University Hospital | 860 | 2026-04-01 | 2026-04-06 | |
| SEAPORT 1: Study of INZ-701 in Adults With Hemodialysis-Dependent End-Stage Kidney Disease INZ-701 - Calciphylaxis | Phase 1 | Completed | Inozyme Pharma | 11 | 2024-02-12 | 2026-08-24 |
| Rheopheresis as Adjuvant Treatment of Calciphylaxis Rheopheresis procedure, Sham-apheresis - Metabolic Disorder, End Stage Renal Disease | Not applicable | Recruiting | University Hospital, Lille | 138 | 2023-03-07 | 2026-02-12 |
| Better Evidence and Translation for Calciphylaxis Vitamin K1, Magnesium citrate, Sodium Thiosulfate - Calciphylaxis | Phase 3 | Recruiting | University of Sydney | 350 | 2021-08-26 | 2025-08-13 |
| Phase 3 Study of SNF472 for Calciphylaxis Experimental: SNF472, Placebo Comparator: Placebo, Experimatenl SNF472 (Open-label) - Calciphylaxis, Calcific Uremic Arteriolopathy | Phase 3 | Completed | Sanifit Therapeutics S. A. | 71 | 2020-02-12 | 2024-02-20 |
| Human Amniotic-Derived Mesenchymal Stem Cell Therapy for Calciphylaxis Human amniotic-derived mesenchymal stem cells - Chronic Kidney Diseases, Calciphylaxis | Early Phase 1 | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 9 | 2018-09-17 | 2026-03-04 |
| Observational Follow-up to ST-001 Calciphylaxis Pain Treatment With Intravenous Sodium Thiosulfate Calciphylaxis | Terminated | Hope Pharmaceuticals | 5 | 2017-10-20 | 2018-11-20 | |
| A Phase 3 Clinical Trial of Intravenous Sodium Thiosulfate in Acute Calciphylaxis Patients Sodium Thiosulfate, Placebo-Normal Saline - Calciphylaxis | Phase 3 | Terminated | Hope Pharmaceuticals | 29 | 2017-05-24 | 2020-05-19 |
| The Early Administration of Sodium Thiosulfate Should Help to Reduce the Mortality of Dialysis Patients With Calciphylaxis, From a National Cohort Sodium Thiosulfate - Calciphylaxis, Renal Insufficiency, Chronic | Unknown | Centre Hospitalier St Esprit | 600 | 2017-05-01 | 2017-05-10 | |
| Partners Calciphylaxis Biobank Calciphylaxis, Calcific Uremic Arteriolopathy | Recruiting | Massachusetts General Hospital | 300 | 2017-01-01 | 2026-09-14 | |
| Calciphylaxis : Population, Risk Factors, Diagnostic Practice, Therapeutic and Outcome Calcific Uremic Arteriolopathy - Calciphylaxis | Completed | Nantes University Hospital | 80 | 2016-07-01 | 2026-06-24 | |
| Phase 2 Study With SNF472 in Calciphylaxis Patients SNF472 - Calciphylaxis, Calcific Uremic Arteriolopathy | Phase 2 | Completed | Sanifit Therapeutics S. A. | 14 | 2016-05-01 | 2019-08-28 |
| European Calciphylaxis Registry Network Calcific Uremic Arteriolopathy (CUA), Calciphylaxis | Unknown | RWTH Aachen University | 1000 | 2015-12-01 | 2016-10-14 | |
| Evaluation of Vitamin K Supplementation for Calcific Uremic Arteriolopathy Vitamin K, Placebo - Calciphylaxis, Calcific Uremic Arteriolopathy | Not applicable | Completed | Massachusetts General Hospital | 26 | 2015-03-01 | 2019-09-17 |
| Double-blind Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic Arteriolopathy Sodium thiosulfate, Placebo - Calciphylaxis, Calcific Uremic Arteriolopathy | Phase 3 | Withdrawn | American Regent, Inc. | 2015-01-30 | 2025-05-07 | |
| Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU) Hypertensive Ischemic Leg Ulcer, Calciphylaxis | Completed | University of Zurich | 120 | 2011-09-01 | 2021-06-18 | |
| Efficacy of Lanthanum Carbonate in Calciphylaxis lanthanum carbonate, Lanthanum for calciphylaxis - Calciphylaxis | Phase 1 | Completed | University of Wisconsin, Madison | 12 | 2011-02-01 | 2014-05-20 |
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Kidney Failure, Chronic (9) · Renal Insufficiency, Chronic (8) · Calcinosis (4) · Calcium Metabolism Disorders (4) · Metabolic Diseases (4) · Rare Diseases (4) · Pressure Ulcer (2) · Pyoderma Gangrenosum (2) · Renal Insufficiency (2) · Vasculitis (2) · Adenine phosphoribosyltransferase deficiency (1) · Atypical Hemolytic Uremic Syndrome (1) · Bartter Syndrome (1) · Bronchiolitis Obliterans Syndrome (1)
Nutritional and Metabolic Diseases (22) · Calcinosis (18) · Calcium Metabolism Disorders (18) · Metabolic Diseases (18) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Female Urogenital Diseases (13) · Female Urogenital Diseases and Pregnancy Complications (13) · Male Urogenital Diseases (13) · Urogenital Diseases (13) · Kidney Diseases (12) · Urologic Diseases (12) · Chronic Disease (11) · Disease Attributes (11) · Renal Insufficiency (9)
sodium thiosulfate (4) · Sodium Chloride (3) · Saline Solution (2) · Lanthanum (1) · Oxygen (1) · SNF472 (1) · Vitamin K (1) · Vitamin K 1 (1) · lanthanum carbonate (1) · magnesium citrate (1) · tocilizumab (1)
Hope Pharmaceuticals (2) · Massachusetts General Hospital (2) · Sanifit Therapeutics S. A. (2) · American Regent, Inc. (1) · Boston Medical Center (1) · Centre Hospitalier St Esprit (1) · Inozyme Pharma (1) · Jay C. Buckey Jr. (1) · Nantes University Hospital (1) · Odense University Hospital (1) · RWTH Aachen University (1) · Sagar U. Nigwekar, MD, MMSc (1) · The First Affiliated Hospital with Nanjing Medical University (1) · U.S. Wound Registry (1) · UK Kidney Association (1)
United States (12) · United Kingdom (4) · France (3) · Germany (2) · Australia (1) · Belgium (1) · Canada (1) · China (1) · Denmark (1) · New Zealand (1) · Poland (1) · Spain (1) · Switzerland (1)
Craig Sherman, MD (2) · Alex Gold, MD (1) · Alexandra Scholze, Dr.med, PhD (1) · Arnaud Lionet, MD (1) · Caroline E Fife, MD (1) · Jay Buckey (1) · Jiayin Liu, Professor (1) · Lianju Qin (1) · Linda Mundy, MD, PhD (1) · Meg Jardine (1) · Micah Chan, MD MPH (1) · Ningning Wang, Professor (1)
PMID 39186385, PMID 32101140, PMID 35142858, PMID 35412950, PMID 36712824, PMID 39234636, PMID 39252867, PMID 40097288, PMID 40518559, PMID 41472909