8 completed, 4 recruiting, 3 unknown, 2 not yet recruiting. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Completed 8, Recruiting 4, Unknown 3, Not yet recruiting 2, Withdrawn 2, Active not recruiting 1 |
Follow Cesarean Delivery: new trials by email Literature Review of Cesarean Delivery trials Research Report on Cesarean Delivery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP) buprenorphine, morphine - Cesarean Delivery | Phase 4 | Recruiting | Icahn School of Medicine at Mount Sinai | 180 | 2026-10-07 | 2026-10-16 |
| Suzetrigine for Opioid-Free Recovery After Cesarean Delivery Suzetrigine, Placebo - Cesarean Delivery, Cesarean Section | Phase 4 | Not yet recruiting | University of Texas at Austin | 90 | 2026-06-01 | 2026-04-16 |
| Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery Clonidine, Dexmedetomidine - Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids | Phase 4 | Recruiting | Columbia University | 150 | 2026-05-14 | 2026-10-29 |
| Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine Spinal Anesthesia with Bupivacaine and Fentanyl, Crystalloid Coload 1000 mL, Cesarean Delivery - Cesarean Delivery, Spinal Anesthesia for Cesarean Section | Phase 4 | Recruiting | Mansoura University | 200 | 2026-01-01 | 2026-01-14 |
| Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial Intrathecal morphine with bupivacaine, Hyperbaric Bupivicaine - Postoperative Pain, Cesarean Delivery | Phase 4 | Not yet recruiting | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 92 | 2025-10-15 | 2025-07-30 |
| Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies Acetaminophen, NSAID (Ketorolac/Ibuprofen) - Cesarean Delivery, Postpartum Comfort | Phase 4 | Active not recruiting | Thomas Jefferson University | 825 | 2025-08-26 | 2026-08-31 |
| COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block Bupivicaine intervention arm, Placebo arm - Complex Obstetric Surgery, Perioperative Pain Management | Phase 4 | Recruiting | University of Tennessee | 120 | 2025-07-15 | 2026-10-21 |
| Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery Intravenous line (IV) Methadone, Intrathecal Morphine - Cesarean Delivery | Phase 4 | Completed | Mayo Clinic | 30 | 2025-02-12 | 2026-10-21 |
| Different Doses of Dexmedetomidine Combined With Esketamine in Women Undergoing Cesarean Delivery Esketamine 0.2 mg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.1 µg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.15 µg/kg - Cesarean Delivery, Esketamine | Phase 4 | Completed | Peking University First Hospital | 120 | 2024-10-08 | 2024-12-30 |
| Epinephrine Infusion for Prophylaxis Against Maternal Hypotension During Cesarean Delivery Epinephrine 0.03, Epinephrin 0.02, Epinephrin 0.01 - Postspinal Hypotension, Cesarean Delivery | Phase 4 | Unknown | Kasr El Aini Hospital | 276 | 2022-03-21 | 2022-08-26 |
| Two Norepinephrine Rescue Bolus Doses for Management of Severe Post-spinal Hypotension During Elective Cesarean Delivery Norepinephrine 5 mcg, Norepinephrine 10 mcg - Postspinal Hypotension, Cesarean Delivery | Phase 4 | Completed | Kasr El Aini Hospital | 158 | 2022-03-11 | 2023-06-18 |
| Intravenous Dexmeditomidine for Prevention of Spinal Anesthesia Induced Shivering. Dexmedetomidine Hydrochloride, Normal Saline - Postoperative Shivering, Cesarean Delivery | Phase 4 | Unknown | Rehman Medical Institute - RMI | 80 | 2022-02-01 | 2022-05-11 |
| ED90 for Hyperbaric Bupivacaine in Super Obese Parturients Bupivacaine - Obesity, Morbid, Spinal Anesthesia | Phase 4 | Completed | Duke University | 45 | 2019-05-01 | 2026-04-17 |
| Effect of the Uterotonic Carbetocin on Acute Post Cesarean-Section Pain Carbetocin - Cesarean Delivery | Phase 4 | Unknown | Insel Gruppe AG, University Hospital Bern | 78 | 2019-02-01 | 2018-05-04 |
| Gabapentin in the Post-cesarean Pain Management of Buprenorphine Patient Gabapentin, Placebo - Cesarean Delivery, Pain Management | Phase 4 | Withdrawn | Vanderbilt University Medical Center | 2018-04-01 | 2019-02-18 | |
| Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression Ketamine, Placebo - Perinatal Depression, Ketamine | Phase 4 | Completed | Peking University First Hospital | 64 | 2017-11-23 | 2021-12-13 |
| Postoperative Cesarean Delivery Pain Relief; Diclofenac Versus Bupivacaine Bupivacaine, Diclofenac - Cesarean Delivery | Phase 4 | Completed | Department of Medical Services Ministry of Public Health of Thailand | 120 | 2017-01-01 | 2020-10-22 |
| Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Vaginal Misoprostol, Foley Balloon + Vaginal Misoprostol - Obesity, Labor Induction | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 236 | 2016-01-01 | 2019-08-26 |
| Serum and Tissue Cefazolin Concentrations in Normal Weight Patients Undergoing Cesarean Delivery. Cefazolin - Infection, Cesarean Delivery | Phase 4 | Withdrawn | West Virginia University | 2011-06-01 | 2013-06-18 | |
| Serum and Tissue Cefazolin Concentrations in Patients Undergoing Cesarean Delivery cefazolin - Cesarean Delivery, Wound Infection | Phase 4 | Completed | Michael Stitely | 23 | 2010-11-01 | 2013-08-21 |
Obesity (3) · Pain, Postoperative (3) · Agnosia (2) · Depression, Postpartum (1) · Infections (1) · Obesity, Morbid (1) · Wound Infection (1)
Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Neurologic Manifestations (4) · Body Weight (3) · Nutrition Disorders (3) · Nutritional and Metabolic Diseases (3) · Overnutrition (3) · Overweight (3) · Pain (3) · Pathologic Processes (3) · Postoperative Complications (3) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2) · Perceptual Disorders (2) · Depressive Disorder (1)
Bupivacaine (4) · Dexmedetomidine (3) · Cefazolin (2) · Morphine (2) · Saline Solution (2) · Acetaminophen (1) · Analgesics, Opioid (1) · Anesthesia, Spinal (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Buprenorphine (1) · Cesarean Section (1) · Clonidine (1) · Diclofenac (1) · Epinephrine (1) · Esketamine (1)
Kasr El Aini Hospital (2) · Peking University First Hospital (2) · Columbia University (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · Duke University (1) · Icahn School of Medicine at Mount Sinai (1) · Insel Gruppe AG, University Hospital Bern (1) · Mansoura University (1) · Mayo Clinic (1) · Michael Stitely (1) · Rehman Medical Institute - RMI (1) · The University of Texas Health Science Center, Houston (1) · Thomas Jefferson University (1) · Tribhuvan University Teaching Hospital, Institute Of Medicine. (1) · University of Tennessee (1)
United States (10) · Egypt (3) · China (2) · Pakistan (1) · Switzerland (1) · Thailand (1)
Michael L Stitely, MD (2) · William H Holls, MD (2) · Ashraf S Habib, MD (1) · Daniel Katz (1) · Daniel Surbek, Prof (1) · Dong-Xin Wang, M.D., PhD. (1) · Dong-Xin Wang, MD, PhD (1) · Emily E Sharpe, M.D. (1) · Holly B Ende, M.D, (1) · Lorie M. Harper, MD, MSCI (1) · Mohammad Shafiq, FCPS (1) · Ruth Landau, MD (1)
PMID 22093385, PMID 32299108, PMID 36570810, PMID 36858257, PMID 36996264, PMID 38264276, PMID 38438681