80 completed, 53 unknown, 35 recruiting, 20 terminated. 65 Not applicable, 25 Phase 2, 18 Phase 4, 12 Phase 3, 11 Phase 1.
Follow Pituitary Neoplasms: new trials by email Literature Review of Pituitary Neoplasms trials Research Report on Pituitary Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perimetry Based on Eye-movements in Patients With (Supra)Sellar Tumors SONDA - Pituitary Tumor, Visual Fields Hemianopsia | Not yet recruiting | University Medical Center Groningen | 30 | 2026-12-01 | 2026-07-23 | |
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| Temozolomide in Aggressive Pituitary Neuroendocrine Tumors: A Latin American Multicenter Retrospective Cohort (TMZ-LATAM) temozolamide, Temozolamide - Pituitary Neoplasms | Not yet recruiting | University of Sao Paulo General Hospital | 80 | 2026-08-01 | 2026-07-10 | |
| Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures Panitumumab-IRDye800 - Meningioma, Glioblastoma | Early Phase 1 | Recruiting | Eben Rosenthal | 30 | 2026-07-07 | 2026-10-16 |
| Direct Versus Video Laryngoscopy in Patients With Acromegaly Acromegaly, Nonfunctioning Pituitary Adenoma | Not yet recruiting | Muzaffer GENCER | 40 | 2026-07-01 | 2026-06-22 | |
| AI in Endoscopic Transsphenoidal Surgery Live intra-op AI analysis of endoscopic video feed, with output displayed on supplementary monitor - Pituitary Adenoma | Early Phase 1 | Not yet recruiting | University College, London | 30 | 2026-06-01 | 2026-05-05 |
| Standardized Patient Education in Pituitary Surgery Standardized Pituitary Training - Pituitary Adenoma | Not applicable | Not yet recruiting | Uludag University | 102 | 2026-06-01 | 2026-06-01 |
| FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease Fluoro-O-(2) fluoroethyl-L-tyrosine (FET) PET - Cushing Disease, Pituitary Adenoma | Early Phase 1 | Recruiting | Mayo Clinic | 50 | 2026-04-27 | 2026-10-30 |
| DDAVP for Pituitary Adenoma Desmopressin acetate - Cushing's Disease, Pituitary Adenoma | Not applicable | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 22 | 2026-03-09 | 2026-04-09 |
| Safety and Potency of a High Cabergoline Dosage in Microprolactinomas Cabergoline - Prolactinoma, Prolactin Excess | Phase 3 | Recruiting | University of Sao Paulo General Hospital | 70 | 2026-03-04 | 2026-03-13 |
| Clinical Trial of an Anti-Fog Drainage Device for Endoscopic Endonasal Sellar Region Tumor Surgery Anti-fog suction device-a 4 Fr multi-channel silicone catheter - Pituitary Adenoma, Craniopharyngioma | Not applicable | Recruiting | West China Hospital | 20 | 2026-03-01 | 2026-06-30 |
| Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas FET-PET/MRI - Pituitary Adenoma | Phase 1 | Recruiting | Mayo Clinic | 5 | 2026-01-08 | 2026-03-09 |
| How Estrogen Fluctuations Before Diagnosis Affect the Size Prolactin-secreting Tumors Standardized questionnaire - Prolactinoma, Macroprolactinoma | Completed | Hospices Civils de Lyon | 171 | 2026-01-06 | 2026-10-23 | |
| Prediction Model for Postoperative Headache After Transsphenoidal Pituitary Surgery Transsphenoidal Pituitary Surgery - Headache, Pituitary Adenoma | Active not recruiting | Beijing Tiantan Hospital | 500 | 2026-01-01 | 2026-03-03 | |
| Ultrasound in Predicting Difficult Intubation in Acromegaly Patients observational study - Acromegaly Due to Pituitary Adenoma, Difficult Intubation | Not yet recruiting | Başakşehir Çam & Sakura City Hospital | 34 | 2025-12-25 | 2025-12-29 | |
| Clinical Evaluation of [68Ga]Ga-NOTA-RF PET Imaging Targeting RFVT3 in Patients With Pituitary Tumors [68Ga]Ga-NOTA-RF - Pituitary Neoplasms | Early Phase 1 | Enrolling by invitation | Peking Union Medical College Hospital | 30 | 2025-11-17 | 2025-11-28 |
| Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region. Standard-of-care PET/CT, NeuroEXPLORER - Dementia, Movement Disorders | Not applicable | Enrolling by invitation | prof. dr. Koen Van Laere | 1600 | 2025-09-30 | 2026-05-19 |
| Metabolic Outcomes in Patients With Prolactinomas Under Dopamine Agonist Treatment Cabergoline (Dopamine Agonist) - Prolactinoma | Phase 4 | Recruiting | University Hospital, Basel, Switzerland | 60 | 2025-09-16 | 2025-09-23 |
| Effects of Pasireotide Lar Therapy on Bone Metabolism morphometric spine radiography - Acromegaly Due to Pituitary Adenoma, Acromegaly | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 120 | 2025-09-08 | 2025-09-18 | |
| NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant - CerebroSpinal Fluid (CSF) Leak | Not applicable | Recruiting | Maria Sklodowska-Curie National Research Institute of Oncology | 225 | 2025-08-15 | 2025-10-14 |
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Prolactinoma (28) · Acromegaly (26) · Pituitary Diseases (20) · Brain Neoplasms (18) · Meningioma (17) · Pituitary ACTH Hypersecretion (13) · Growth Hormone-Secreting Pituitary Adenoma (12) · Craniopharyngioma (9) · Glioma (8) · Glioblastoma (7) · Medulloblastoma (7) · Neoplasms (7) · Astrocytoma (6) · Neuroectodermal Tumors, Primitive (6)
Brain Diseases (215) · Central Nervous System Diseases (215) · Hypothalamic Diseases (215) · Neoplasms by Site (215) · Endocrine Gland Neoplasms (214) · Endocrine System Diseases (214) · Nervous System Diseases (214) · Neoplasms (208) · Pituitary Diseases (195) · Hypothalamic Neoplasms (192) · Nervous System Neoplasms (192) · Supratentorial Neoplasms (192) · Central Nervous System Neoplasms (187) · Brain Neoplasms (174) · Neoplasms by Histologic Type (70)
Cabergoline (13) · pasireotide (9) · Surgical Procedures, Operative (5) · Dexmedetomidine (3) · Hydrocortisone (3) · Propofol (3) · Proton Therapy (3) · Temozolomide (3) · Aminolevulinic Acid (2) · Desflurane (2) · Dexamethasone (2) · Diet, Ketogenic (2) · Dopamine Agonists (2) · Human Growth Hormone (2) · Octreotide (2)
Huashan Hospital (8) · Novartis Pharmaceuticals (8) · Federico II University (6) · Peking Union Medical College Hospital (6) · St. Joseph's Hospital and Medical Center, Phoenix (6) · Columbia University (5) · National Institute of Neurological Disorders and Stroke (NINDS) (5) · University Hospital, Basel, Switzerland (5) · Zhebao Wu (5) · Beijing Tiantan Hospital (4) · Hospices Civils de Lyon (4) · Mayo Clinic (4) · Cedars-Sinai Medical Center (3) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3)
United States (69) · China (33) · Italy (17) · France (16) · Turkey (Türkiye) (12) · Brazil (11) · Canada (10) · Germany (10) · Netherlands (9) · South Korea (9) · United Kingdom (8) · Belgium (7) · Switzerland (7) · Taiwan (6) · Argentina (5)
Andrew Little, MD (3) · Annamaria AL Colao, Prof. (3) · Bing Xing, MD (3) · Gilda Cennamo (3) · Prashant Chittiboina, M.D. (3) · Wei Lian, MD (3) · Yao Zhao, M.D. (3) · Andrew S Little, MD (2) · Anthony Heaney, MD (2) · Deborah P Merke, M.D. (2) · Harry T Whelan, MD (2) · Jung Hee Kim, M.D (2) · Sabrina Chiloiro (2)
PMID 19556464, PMID 22154461, PMID 25209242, PMID 27864853, PMID 29343557, PMID 29395172, PMID 31062234, PMID 35954244, PMID 10022400, PMID 10199767, PMID 10199774, PMID 10372687, PMID 10469005, PMID 10690849, PMID 10999798, PMID 11207626, PMID 11273062, PMID 11344175, PMID 11397887, PMID 11531927, PMID 11880025, PMID 11889170, PMID 12390688, PMID 12843148, PMID 12924350, PMID 12934784, PMID 14627787, PMID 14764779, PMID 15070920, PMID 15081648, PMID 15126541, PMID 15355453, PMID 15579750, PMID 15585563, PMID 15613435, PMID 15671089, PMID 15827109, PMID 15886238, PMID 15886256, PMID 15985481, PMID 16148287, PMID 16267335, PMID 16373932, PMID 16449332, PMID 16487447, PMID 16509142, PMID 16537687, PMID 16690338, PMID 16705142, PMID 17202453
2025 (2), 2004 (1), 2008 (1), 2009 (1), 2014 (1), 2018 (1), P30CA138292 (1), R01NS052274 (1), R01NS070600 (1), R21DK112093 (1), R56DK064720 (1), U01CA097452 (1)