28 terminated. 28 Phase 2, 5 Phase 3, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 28 | Terminated 28 |
| Phase 3 | 5 | Terminated 5 |
| Phase 1 | 4 | Terminated 4 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of CRD-4730 in Participants With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) CRD-4730, Placebo - CPVT1, Heart Defects, Congenital | Phase 2 | Terminated | Cardurion Pharmaceuticals, Inc. | 7 | 2023-11-07 | 2026-05-27 |
| Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2). LQT-1213, Placebo, Dofetilide 250 μg Cap - Long QT Syndrome | Phase 1 / Phase 2 | Terminated | Thryv Therapeutics, Inc. | 42 | 2023-03-12 | 2025-07-24 |
| Specialized Pacing for Patients With Congenital Heart Disease Closed loop stimulation, Standard rate response - Congenital Heart Disease, Bradycardia Sinus | Phase 2 / Phase 3 | Terminated | University of California, Los Angeles | 4 | 2021-05-09 | 2023-01-20 |
| Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging Nebivolol, Diltiazem, Placebo - Myocardial Bridging | Phase 2 | Terminated | Stanford University | 5 | 2020-10-15 | 2025-02-25 |
| ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery Fibrinogen Concentrate Human, Prothrombin Complex Concentrate, Fresh Frozen Plasma - Bleeding, Cardiac Defect | Phase 2 | Terminated | IRCCS Policlinico S. Donato | 40 | 2020-02-27 | 2021-11-03 |
| Use of Oxandrolone to Promote Growth in Infants With HLHS Oxandrolone - Hypoplastic Left Heart, Congenital Heart Disease | Phase 1 / Phase 2 | Terminated | Carelon Research | 34 | 2019-12-20 | 2024-05-23 |
| Synaptic Plasticity and Cognitive Function in RASopathies Lovastatin, Lamotrigine - Impaired Synaptic Plasticity, Impaired Cognition | Phase 2 | Terminated | Technical University of Munich | 16 | 2019-03-22 | 2023-11-30 |
| Fenoldopam to Prevent Renal Dysfunction in Indomethacin Treated Preterm Infants Fenoldopam, 0.9%NS - Patent Ductus Arteriosus (PDA), Acute Kidney Injury (AKI) | Phase 2 / Phase 3 | Terminated | Medical College of Wisconsin | 1 | 2019-02-06 | 2022-09-16 |
| Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus Ibuprofen and acetaminophen, Ibuprofen and placebo - Patent Ductus Arteriosus, Preterm Infant | Phase 2 | Terminated | University of South Alabama | 1 | 2018-12-15 | 2026-04-30 |
| Colchicine in Postoperative Fontan Patients Colchicine - Single-ventricle, Heart Diseases | Phase 2 / Phase 3 | Terminated | University of Michigan | 11 | 2018-08-29 | 2022-05-09 |
| Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation Propranolol, DNA and RNA Analysis - Cerebral Cavernous Malformations | Phase 2 | Terminated | St. Joseph's Hospital and Medical Center, Phoenix | 4 | 2018-01-24 | 2024-04-19 |
| A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Vincristine, Sirolimus - Kaposiform Hemangioendothelioma (KHE), Kasabach-Merritt Syndrome | Phase 2 | Terminated | Boston Children's Hospital | 4 | 2017-06-14 | 2023-09-21 |
| Acute Effects of Inhaled Treprostinil in Fontan Patients Treprostinil, Placebo - Congenital Heart Disease | Phase 2 | Terminated | Children's Hospital Medical Center, Cincinnati | 15 | 2017-02-21 | 2020-07-29 |
| Erythropoietin to Prevent Unnecessary Transfusions In Patients With Cyanotic CHD - A Prospective Control Trial Epoetin Alfa and Iron, Iron - Cyanotic Congenital Heart Disease, Anemia | Phase 2 | Terminated | University of California, San Diego | 4 | 2016-11-01 | 2021-12-02 |
| The LIPMAT Study: Liposomal Prednisolone to Improve Hemodialysis Fistula Maturation PEG-liposomal prednisolone sodium phosphate, Placebo - Renal Dialysis, Hemodynamics | Phase 2 | Terminated | Leiden University Medical Center | 30 | 2015-11-01 | 2018-09-18 |
| Evaluation of Pazopanib on Bleeding in Subjects With Hereditary Haemorrhagic Telangiectasia Pazopanib, Placebo - Telangiectasia, Hereditary Hemorrhagic | Phase 2 | Terminated | GlaxoSmithKline | 7 | 2015-02-25 | 2017-07-06 |
| Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Bevacizumab, placebo - Hereditary Hemorrhagic Telangiectasia, Epistaxis | Phase 2 / Phase 3 | Terminated | Hospices Civils de Lyon | 80 | 2014-04-01 | 2015-11-20 |
| Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery Sodium Bicarbonate, Sodium Chloride - Acute Kidney Injury, Congenital Heart Disease | Phase 2 | Terminated | Northwell Health | 51 | 2013-09-01 | 2022-11-02 |
| Efficacy and Local Tolerability of Topically Applied Heparin on the Suitability of Newly Constructed Primary Arteriovenous Fistulas in Patients Planned for Haemodialysis Heparin 2,400 IU /ml Cutaneous Spray, Placebo Cutaneous Spray - Haemodialysis | Phase 2 | Terminated | Cyathus Exquirere Pharmaforschungsgmbh | 30 | 2011-07-01 | 2014-05-08 |
| Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Metyrosine, Placebo - Velo-cardio-facial Syndrome, Psychosis | Phase 2 | Terminated | Bausch Health Americas, Inc. | 2 | 2010-06-01 | 2019-11-22 |
Showing 20 of 28. Sign in to see all of them.
Heart Defects, Congenital (11) · Arteriovenous Fistula (3) · Ductus Arteriosus, Patent (3) · Acute Kidney Injury (2) · Heart Diseases (2) · Hemorrhage (2) · Noonan Syndrome (2) · Telangiectasia, Hereditary Hemorrhagic (2) · Afibrinogenemia (1) · Anemia (1) · Bronchopulmonary Dysplasia (1) · Cognition Disorders (1) · Cyanosis (1) · DiGeorge Syndrome (1) · Epistaxis (1)
Cardiovascular Diseases (28) · Congenital Abnormalities (28) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (28) · Heart Diseases (19) · Heart Defects, Congenital (10) · Pathological Conditions, Signs and Symptoms (10) · Pathologic Processes (8) · Hemic and Lymphatic Diseases (7) · Hematologic Diseases (6) · Vascular Diseases (6) · Vascular Malformations (6) · Female Urogenital Diseases and Pregnancy Complications (4) · Hemorrhagic Disorders (4) · Urogenital Diseases (4)
Natriuretic Peptide, Brain (2) · Acetaminophen (1) · Bevacizumab (1) · Capsules (1) · Colchicine (1) · DNA (1) · Diltiazem (1) · Epoetin Alfa (1) · Factor IX (1) · Fenoldopam (1) · Fibrinogen (1) · Heparin (1) · Ibuprofen (1) · Indomethacin (1) · Iron (1)
Boston Children's Hospital (2) · The Hospital for Sick Children (2) · Abbott Medical Devices (1) · Bausch Health Americas, Inc. (1) · Cardurion Pharmaceuticals, Inc. (1) · Carelon Research (1) · Children's Hospital Medical Center, Cincinnati (1) · Cyathus Exquirere Pharmaforschungsgmbh (1) · Dr. Lisa Miller (1) · GlaxoSmithKline (1) · Hospices Civils de Lyon (1) · IRCCS Policlinico S. Donato (1) · Insmed Incorporated (1) · John M Costello (1) · Leiden University Medical Center (1)
United States (18) · Canada (8) · France (2) · Germany (2) · Italy (2) · Austria (1) · Netherlands (1) · Switzerland (1) · United Kingdom (1)
Amuchou S Soraisham, MD, DM (1) · Ben Sivarajan, MD (1) · Brian McCrindle, MD (1) · David K Werho, MD (1) · Denise Adams, MD (1) · Fabien Eyal, MD (1) · Gruschen Veldtman, MBChB (1) · James Schneider, MD (1) · Jan Matousek, DO (1) · Jason Homsy, M.D., Ph.D. (1) · Jeffrey Segar, MD (1) · Jennifer Tremmel, MD, MS (1) · John M Costello, MD (1) · John M Costello, MD MPH (1)
PMID 24906491, PMID 26908949, PMID 27599328, PMID 36408876, PMID 37280688, PMID 39607014, PMID 39625244
2016 (1)