8 completed, 6 recruiting, 3 suspended, 3 unknown. 25 Phase 2, 5 Phase 1, 3 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Repeated Administration of Cannabis Varying in THC and CBD Cannabis - Cannabis | Phase 2 | Suspended | New York State Psychiatric Institute | 100 | 2026-10-01 | 2026-09-01 |
| A Study of Inhaled Cannabidiol in Healthy Occasional Cannabis Users Cannabis, placebo - Cannabis | Phase 1 / Phase 2 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 80 | 2026-09-01 | 2025-12-22 |
| Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration Cannabis, Nicotine, Pax Loose Leaf Vaporizer - THC, Cannabis | Phase 2 | Recruiting | University of California, San Francisco | 48 | 2025-07-01 | 2026-01-07 |
| Modulation of THC Effects by CBD: a Dose-ranging Study ∆9-tetrahydrocannabinol - Cannabis, THC | Phase 1 / Phase 2 | Recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 100 | 2024-06-27 | 2025-12-22 |
| Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy Aurora 1:1 Drops (Indica), Placebo - Opioid Use Disorder, Methadone | Phase 2 | Recruiting | BC Centre on Substance Use | 24 | 2024-05-23 | 2025-02-17 |
| Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV THC, CBD - HIV, Cannabis | Phase 2 | Recruiting | University of California, San Diego | 90 | 2023-09-01 | 2026-05-01 |
| Cannabis' Impact on Alcohol Consumption THC-dominant cannabis, CBD-dominant cannabis, Cannabis placebo - Alcohol Drinking, Cannabis Use | Phase 2 | Recruiting | Brown University | 350 | 2023-03-16 | 2026-10-05 |
| Dose-Ranging Trial of Inhaled Cannabis for Acute Migraine Treatment THC ~2.5%, THC ~5%, THC ~10% - Migraine, Cannabis | Phase 2 | Suspended | University of California, San Diego | 20 | 2023-02-15 | 2026-03-16 |
| ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids Nabiximols, Temozolomide, Nabiximols-matched placebo - Glioblastoma, Brain Tumor | Phase 2 | Active not recruiting | University of Birmingham | 122 | 2023-02-03 | 2026-10-16 |
| A Study of Ingested Cannabidiol in Healthy Occasional Cannabis Users cannabis 0 mg, placebo, Cannabis 20 mg,, Cannabis 50 mg - Cannabis | Phase 1 / Phase 2 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 70 | 2022-07-22 | 2024-04-22 |
| THC Memory & Reward Learning Pilot Marijuana, Hash, THC, or Grass, Placebo - Marijuana, THC | Phase 1 / Phase 2 | Unknown | Hartford Hospital | 20 | 2022-07-07 | 2025-03-17 |
| Impact of Repeatedly-Administered THC-cannabis on Experimental Pain and Abuse Liability in Humans Active Cannabis, Placebo Cannabis - Cannabis, Pain | Phase 2 | Suspended | New York State Psychiatric Institute | 16 | 2021-08-01 | 2026-09-24 |
| Repeated Cannabis Administration on Experimental Pain and Abuse Liability Active Cannabis, Placebo Cannabis - Cannabis, Pain | Phase 2 | Completed | New York State Psychiatric Institute | 10 | 2021-06-01 | 2025-08-08 |
| A Pilot Study on the Effect of Cannabis Oil in Untreatable Liver Cancer Patients Medical Cannabis - Hepatocellular Carcinoma, Cannabis | Phase 2 | Recruiting | University Medical Center Groningen | 20 | 2021-04-15 | 2024-07-24 |
| Methodology for Developing an Occlusal Appliance With CBD Active Carrier CBD occlusal appliance, Acrylic resin occlusal appliance - Temporomandibular Disorder, Myofascial Pain | Phase 2 / Phase 3 | Unknown | Medical University of Silesia | 40 | 2021-01-01 | 2021-03-01 |
| Efficacy of Inhaled Cannabis for Acute Migraine Treatment THC ~5%, CBD ~12%, THC ~5% and CBD ~12% - Migraine, Cannabis | Phase 2 | Completed | University of California, San Diego | 92 | 2020-11-20 | 2023-02-28 |
| Enhancing Medication-based Analgesia in Humans- STUDY 2 Within-subject test of blinded study medications - Pain, Cannabis | Phase 2 | Completed | Johns Hopkins University | 31 | 2020-02-01 | 2023-12-19 |
| Phase II Clinical Trial, Use of KL16-012 in Women With Fibromyalgia Refractary to Conventional Treatment. KL16-012, Placebo - Fibromyalgia, Cannabis | Phase 2 | Unknown | Knop Laboratorios | 44 | 2020-01-15 | 2020-01-27 |
| Cannabidiol Usage as an Adjunct Therapy for Crohn's Disease Cannabidiol, Placebo oral capsule - Crohn Disease, Inflammatory Bowel Diseases | Phase 2 / Phase 3 | Withdrawn | University of Illinois at Chicago | 2018-07-01 | 2020-03-25 | |
| Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain Cannabis - Cannabis, HIV Neuropathy | Phase 2 | Completed | University of California, San Diego | 5 | 2018-07-01 | 2024-06-18 |
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Marijuana Abuse (25) · Pain (5) · Agnosia (2) · Behavior, Addictive (2) · Hyperalgesia (2) · Migraine Disorders (2) · Neuralgia (2) · Temporomandibular Joint Disorders (2) · Alcohol Drinking (1) · Alcoholism (1) · Anorexia (1) · Brain Neoplasms (1) · Cachexia (1) · Carcinoma, Hepatocellular (1) · Crohn Disease (1)
Chemically-Induced Disorders (25) · Mental Disorders (25) · Substance-Related Disorders (25) · Nervous System Diseases (11) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (8) · Neurologic Manifestations (7) · Behavior (3) · Brain Diseases (3) · Central Nervous System Diseases (3) · Digestive System Diseases (3) · Muscular Diseases (3) · Musculoskeletal Diseases (3) · Neoplasms by Site (3) · Neuromuscular Diseases (3)
nabiximols (12) · Dronabinol (6) · Cannabidiol (5) · THC 5 (2) · salicylhydroxamic acid (2) · Cannabinoids (1) · Ethanol (1) · Medical Marijuana (1) · Nicotine (1) · Propranolol (1) · Sugars (1) · Temozolomide (1) · nabilone (1)
University of California, San Diego (5) · New York State Psychiatric Institute (4) · Centre hospitalier de l'Université de Montréal (CHUM) (3) · Johns Hopkins University (2) · Medical University of Silesia (2) · BC Centre on Substance Use (1) · Brown University (1) · Hartford Hospital (1) · Jens Rikardt Andersen (1) · Knop Laboratorios (1) · University Medical Center Groningen (1) · University of Birmingham (1) · University of California, San Francisco (1) · University of Illinois at Chicago (1)
United States (14) · Canada (3) · Poland (2) · Denmark (1) · Netherlands (1) · United Kingdom (1)
Claudia Campbell, PhD (2) · Didier Jutras-Aswad, MD,MS (2) · Nathaniel M Schuster, MD (2) · Brook L Henry, PhD (1) · Didier Jutras-Aswad, MD, MS (1) · Fiona Collinson, MBBS, BSc, MRCP, FRCR, PhD (1) · Gideon St Helen (1) · Godfrey Pearlson, M.D (1) · Jane Metrik, PhD (1) · Jens Rikardt Andersen, MD, MPA (1) · Kelly Dunn, PhD (1) · Kelly E Dunn, PhD (1) · M Eugenia Socias, MD, MSc. (1) · M W Nijkamp, MD PhD (1) · Magdalena Antonowicz, Adiunct (1)
PMID 12648025, PMID 16317825, PMID 17566383, PMID 18728826, PMID 19587829, PMID 19883531, PMID 19896326, PMID 20076976, PMID 22076835, PMID 23141881, PMID 26883879, PMID 27403414, PMID 40839659, PMID 41469488, PMID 41514385, PMID 42454450
R01AA029711 (1), R01DA038634 (1), R01DA040644 (1), R01DA056451 (1), R21DA050752 (1), U54DA037842 (1)