19 completed, 4 terminated, 3 active not recruiting, 3 recruiting. 9 Phase 3, 5 Phase 4, 4 Phase 1, 3 Not applicable, 3 Phase 2.
Follow Breakthrough Pain: new trials by email Literature Review of Breakthrough Pain trials Research Report on Breakthrough Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Failing Epidural Analgesia During Labor No Intervention: Observational Cohort - Failed Epidural Analgesia, Post-partum Recovery | Recruiting | Nicolas Brogly | 500 | 2026-01-12 | 2026-09-18 | |
| Dexamethasone-Enhanced TAP Block in Lapchole Dexamethasone enhanced TAP Block, Marcaine- 0.25% - Laparoscopic Cholecystectomy | Phase 1 | Active not recruiting | Makassed General Hospital | 100 | 2025-08-19 | 2025-09-19 |
| Paediatric Breakthrough Pain Assessment Breakthrough Pain, Palliative Medicine | Not yet recruiting | University of Southampton | 210 | 2025-01-20 | 2025-01-24 | |
| Programmed Intermittent Epidural Bolus Compared With Continuous Infusion in Multiparous Women programmed intermittent Bolus epidural analgesia, continuous epidural infusion - Breakthrough Pain | Not applicable | Recruiting | Holy Family Hospital, Nazareth, Israel | 186 | 2024-09-25 | 2026-04-13 |
| PIEB Compared With CEI on Breakthrough Pain in Nulliparous Women programmed intermittent Bolus epidural analgesia, continuous epidural infusion - Breakthrough Pain | Not applicable | Recruiting | Holy Family Hospital, Nazareth, Israel | 240 | 2024-09-10 | 2026-04-13 |
| Proportional Dose of Sublingual Fentanyl Tablet Based on Daily Opioid Requirement Intravenous Infusion, Sublingual Tablet - Cancer Pain, Breakthrough Pain | Not applicable | Withdrawn | Seoul National University | 2022-12-01 | 2023-08-07 | |
| A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy Non-Narcotic ERAS Post-Operative Pain Management - Analgesia, Post-Operative Pain | Phase 4 | Unknown | University of Vermont | 25 | 2022-02-07 | 2022-10-14 |
| Efficacy of Injectable Fentanyl in Sublingual Route Versus Oral Morphine Syrup for Breakthrough Pain Fentanyl Citrate 50Mcg/Ml Inj_#1, Morphine - Pain, Breakthrough | Phase 1 / Phase 2 | Completed | Department of Medical Services Ministry of Public Health of Thailand | 20 | 2021-06-15 | 2022-08-31 |
| Development of Variable Volume Automated Mandatory Boluses for Patient-controlled Epidural Analgesia During Labour Epidural infusion pump, Ropivacaine, Fentanyl - Labor Pain, Breakthrough Pain | Phase 3 | Active not recruiting | KK Women's and Children's Hospital | 197 | 2020-08-11 | 2026-08-14 |
| Effectiveness and Tolerance of Fentanyl Citrate in Painful Pain Induced During Diagnostic or Therapeutic Examinations in Cancer Patients Fentanyl citrate, Placebo - Breakthrough Pain | Phase 2 | Withdrawn | UNICANCER | 2020-02-01 | 2020-04-22 | |
| Quality of Life Study Breakthrough Cancer Pain Treated in Medical Oncology Services (CAVIDIOM) No intervention - Breakthrough Pain | Completed | Angelini Farmacéutica | 118 | 2017-12-21 | 2020-03-02 | |
| Quality of Life Study Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent No intervention - Breakthrough Pain | Completed | Angelini Farmacéutica | 79 | 2016-07-08 | 2018-03-05 | |
| Quality of Life Study in Patients With Cancer Breakthrough Pain Treated in Palliative Care Units No intervention - Breakthrough Pain | Completed | Angelini Farmacéutica | 101 | 2016-06-27 | 2018-03-05 | |
| Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain Bupivacaine, Opioid - Pain, Intractable, Breakthrough Pain | Phase 4 | Completed | University Hospitals Cleveland Medical Center | 17 | 2016-05-01 | 2022-03-24 |
| Procedural Pain in Palliative Care: Prevalence, Intensity and Treatment Mobilization, Positioning, Personal Hygiene Care - Breakthrough Pain, Pain Due to Certain Specified Procedures | Completed | Antea Foundation | 1079 | 2015-06-01 | 2016-07-12 | |
| Analgesic Efficacy of Transmucosal Fentanyl for Breakthrough Pain Caused by Interventional Gastrostomy Fentanyl, Morphine Sulfate, Fentanyl placebo - Gastrostomy, Breakthrough Pain | Phase 4 | Completed | Central Hospital, Nancy, France | 20 | 2015-05-01 | 2019-05-13 |
| Comparison of Regimens MPIB, CIPCEA, PCEA epidural delivery system, Ropivacaine, Fentanyl - Breakthrough Pain | Phase 3 | Active not recruiting | KK Women's and Children's Hospital | 839 | 2015-01-28 | 2026-08-07 |
| An Observational, Non-Interventional Trial to Assess Patient Satisfaction and Safety of Subsys™ Spray. Breakthrough Pain | Terminated | International Clinical Research Institute | 4 | 2013-04-01 | 2014-09-04 | |
| Intranasal Transmucosal Fentanyl Pectin for Breakthrough Cancer Pain in Radiation-induced Oropharyngeal Mucositis Breakthrough Pain, Mucositis | Completed | Grupo de Investigación Clínica en Oncología Radioterapia | 33 | 2012-12-01 | 2015-03-17 | |
| The Cancer Pain and Unmet Needs Study Cancer | Terminated | University of Surrey | 162 | 2012-07-01 | 2023-05-31 |
Showing 20 of 33. Sign in to see all of them.
Cancer Pain (7) · Neoplasms (7) · Pain (6) · Chronic Pain (4) · Agnosia (3) · Head and Neck Neoplasms (2) · Acute Pain (1) · Anemia, Sickle Cell (1) · Burns (1) · Labor Pain (1) · Mucositis (1) · Pain, Intractable (1) · Pain, Postoperative (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1)
Neurologic Manifestations (33) · Pathological Conditions, Signs and Symptoms (33) · Signs and Symptoms (33) · Pain (27) · Neoplasms (3) · Nervous System Diseases (3) · Neurobehavioral Manifestations (3) · Perceptual Disorders (3) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Neoplasms by Site (2) · Anemia (1) · Anemia, Hemolytic (1) · Anemia, Hemolytic, Congenital (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Fentanyl (13) · Analgesics, Opioid (3) · Bupivacaine (3) · Morphine (3) · Ropivacaine (2) · Administration, Sublingual (1) · Gastrostomy (1) · Hydromorphone (1) · Infusions, Intravenous (1) · Methadone (1) · Passive Cutaneous Anaphylaxis (1) · Patient Positioning (1) · Ultracet (1) · Urinary Catheterization (1)
Cephalon (6) · Angelini Farmacéutica (3) · Holy Family Hospital, Nazareth, Israel (2) · KK Women's and Children's Hospital (2) · Kyowa Kirin Co., Ltd. (2) · AHS Cancer Control Alberta (1) · Alexza Pharmaceuticals, Inc. (1) · Antea Foundation (1) · Central Hospital, Nancy, France (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · Ethypharm (1) · Grupo de Investigación Clínica en Oncología Radioterapia (1) · International Clinical Research Institute (1) · Johnson & Johnson Taiwan Ltd (1) · Makassed General Hospital (1)
United States (9) · Spain (6) · France (2) · Germany (2) · Israel (2) · Italy (2) · Singapore (2) · United Kingdom (2) · Czechia (1) · Ireland (1) · Japan (1) · Lebanon (1) · Poland (1) · Puerto Rico (1) · Thailand (1)
Raed Salim, MD (2) · Albert Tuca, MD (1) · Alejandro De la Torre, MD (1) · Alison L Buchanan, BSc (1) · Ban L Sng, FANZCA (1) · Carlos Camps Herrero (1) · Christina Liossi, DPsych (1) · Dr. Thomas D. Bethke, PhD; MD (1) · Giuseppe Casale, Medicine (1) · Jee Youn Moon, MD, PhD (1) · John Messina, Pharm D (1) · Julian Howell (1) · Neil Hagen (1)
PMID 10353500, PMID 18258412, PMID 19508134, PMID 21208151, PMID 21215653, PMID 21957829, PMID 23380337, PMID 23855816, PMID 24385406, PMID 24508417, PMID 24839047, PMID 30202425, PMID 32229524, PMID 33289432, PMID 33533986, PMID 33933619, PMID 35137627, PMID 36600856, PMID 37083674, PMID 37170709, PMID 38671702, PMID 38751563, PMID 38782390, PMID 39709396
2008 (1), 2014 (1)