1870 completed, 299 recruiting, 292 terminated, 259 unknown. 3144 Phase 1, 899 Phase 2.
Follow Brain Diseases: new trials by email Literature Review of Brain Diseases trials Research Report on Brain Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies | Phase 1 / Phase 2 | Not yet recruiting | Qiang Zhang | 40 | 2027-10-01 | 2026-03-12 |
| Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau Neuronavigation-guided single-element focused ultrasound transducer, Lumason, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents - Alzheimer Disease, Early Onset | Phase 1 | Not yet recruiting | Columbia University | 6 | 2027-08-01 | 2026-05-13 |
| Fecal MicrobiotaTransplant for the Treatment of Parkinson's Disease Fecal Microbiota Transplant - Parkinson Disease | Phase 1 | Not yet recruiting | ProgenaBiome | 10 | 2027-07-01 | 2026-10-09 |
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-10-30 |
| Sustained Release Oral Formulation For Treatment Of Parkinsons Disease Formulation A, Formulation B, Formulation C - Healthy Volunteers | Phase 1 / Phase 2 | Not yet recruiting | University of Minnesota | 32 | 2027-04-01 | 2026-10-01 |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Prenatal Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis Clinical Trial Gene Transfer with an AAV9 Vector Expressing Human ß-galactosidase - GM1 Gangliosidoses, GM1 Gangliosidosis, Type I | Phase 1 | Not yet recruiting | Tippi Mackenzie | 5 | 2027-01-01 | 2026-08-31 |
| Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage Sirolimus (Rapamune®) - Post-hemorrhagic Hydrocephalus (PHH) | Phase 1 / Phase 2 | Not yet recruiting | Massachusetts General Hospital | 15 | 2027-01-01 | 2026-06-25 |
| Outside the Cage (OTC) Robotic Esophagectomy OTC MIE Esophagectomy - Esophageal Cancer | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 31 | 2027-01-01 | 2026-03-18 |
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| Relaxin Therapy for Atrial Fibrillation Relaxin, Placebo - Atrial Fibrillation (AF), Arrhythmia | Phase 1 / Phase 2 | Not yet recruiting | Deeptankar DeMazumder | 208 | 2027-01-01 | 2026-01-22 |
| Intra-Arterial Bevacizumab as an Adjunct to Middle Meningeal Artery Embolization for Chronic Subdural Hematoma Bevacizumab (intra-arterial) - Chronic Subdural Hematoma | Phase 1 | Not yet recruiting | Dheeraj Gandhi | 18 | 2027-01-01 | 2026-07-27 |
| IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells - High-grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 1 | Not yet recruiting | University of Florida | 24 | 2027-01-01 | 2026-10-30 |
| The Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ACI) in the Treatment of Acute Cerebral Infarction Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), Aspirin Tablet - Cerebral Infarction | Phase 1 | Suspended | Sclnow Biotechnology Co., Ltd. | 40 | 2026-12-31 | 2026-04-23 |
| Human Umbilical Cord Mesenchymal Stem Cell Therapy (19#iSCLife®-CI) for Cerebral Infarction Patients in Convalescent Period. Allogeneic umbilical cord mesenchymal stem cell, Aspirin Enteric-coated Tablets & Atorvastatin Calcium - Cerebral Infarction | Phase 1 / Phase 2 | Suspended | Sclnow Biotechnology Co., Ltd. | 40 | 2026-12-31 | 2026-04-23 |
| 4SCAR-T Therapy Targeting GD2, PSMA and CD276 for Treating Neuroblastoma GD2, PSMA and CD276 CAR-T cells - Neuroblastoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 100 | 2026-12-31 | 2026-10-30 |
| Immune Modulatory DC Vaccine Against Brain Tumor Immunomodulatory DC vaccine to target DIPG and GBM - Diffuse Intrinsic Pontine Glioma or Glioblastoma | Phase 1 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 10 | 2026-12-31 | 2026-10-30 |
| Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2) Tirofiban, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Not yet recruiting | Dr David Hasan, M.D. | 82 | 2026-12-05 | 2026-11-04 |
| Repurposing a Combination Antiretroviral Drug Therapy to Target Retrotransposons and Treat Early Alzheimer's Disease Emtricitabine and tenofovir disoproxil fumarate combination, Placebo - Alzheimer's Disease | Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 20 | 2026-12-01 | 2026-08-31 |
Showing 20 of 3144. Sign in to see all of them.
Brain Neoplasms (589) · Alzheimer Disease (558) · Parkinson Disease (435) · Glioblastoma (291) · Stroke (282) · Glioma (235) · Astrocytoma (205) · Central Nervous System Neoplasms (170) · Gliosarcoma (156) · Oligodendroglioma (149) · Epilepsy (144) · Ischemic Stroke (133) · Dementia (102) · Migraine Disorders (100) · Medulloblastoma (94)
Nervous System Diseases (3114) · Central Nervous System Diseases (3098) · Neurodegenerative Diseases (1120) · Mental Disorders (738) · Neoplasms by Site (698) · Neurocognitive Disorders (695) · Nervous System Neoplasms (685) · Neoplasms (657) · Dementia (588) · Cardiovascular Diseases (573) · Pathological Conditions, Signs and Symptoms (570) · Vascular Diseases (570) · Tauopathies (564) · Basal Ganglia Diseases (554)
Temozolomide (79) · Radiotherapy (42) · Radiosurgery (35) · Donepezil (33) · eslicarbazepine acetate (30) · opicapone (30) · Sodium Chloride (28) · Bevacizumab (26) · Saline Solution (23) · Carboplatin (22) · Transcranial Direct Current Stimulation (22) · carbidopa, levodopa drug combination (22) · Cyclophosphamide (21) · Magnetic Resonance Spectroscopy (21) · pembrolizumab (21)
National Cancer Institute (NCI) (85) · Bial - Portela C S.A. (75) · GlaxoSmithKline (41) · Pfizer (41) · Eli Lilly and Company (36) · National Institute of Neurological Disorders and Stroke (NINDS) (34) · Merck Sharp & Dohme LLC (33) · M.D. Anderson Cancer Center (29) · Wyeth is now a wholly owned subsidiary of Pfizer (29) · Duke University (26) · University of Florida (24) · Mayo Clinic (22) · AstraZeneca (21) · H. Lundbeck A/S (21) · University of California, San Francisco (20)
United States (1858) · China (199) · United Kingdom (187) · Canada (153) · Australia (130) · France (123) · Germany (112) · Netherlands (81) · Spain (76) · South Korea (69) · Japan (64) · Sweden (52) · Belgium (51) · Israel (42) · Italy (42)
Danna Jennings, MD (12)
PMID 37624739, PMID 33175411, PMID 40680102, PMID 24524452, PMID 29480210, PMID 30741694, PMID 31127735, PMID 32250312, PMID 36463457, PMID 36602886, PMID 37996817, PMID 38489195, PMID 38588457, PMID 40739200, PMID 10816186, PMID 17562928, PMID 19717023, PMID 20734360, PMID 22163120, PMID 23377664, PMID 23545055, PMID 23860343, PMID 24412048, PMID 25789616, PMID 26925577, PMID 27955995, PMID 28403842, PMID 29063518, PMID 29063814, PMID 29671202, PMID 29749279, PMID 29862060, PMID 30052328, PMID 30134967, PMID 30355322, PMID 30361858, PMID 30739747, PMID 31048098, PMID 31710340, PMID 33236783, PMID 33332761, PMID 33754315, PMID 34174279, PMID 34389161, PMID 34521461, PMID 35949912, PMID 36196048, PMID 36279795, PMID 37171121, PMID 38072889
2014 (17), 2023 (17), 2019 (15), 2018 (14), 2015 (13), 2016 (11), 2025 (11), U01CA081457 (10), 2017 (8), P30CA033572 (8), U01CA137443 (7), 2009 (6), U01CA097452 (5), UM1CA081457 (5), UM1CA097452 (5)