168 completed, 37 recruiting, 31 active not recruiting, 31 terminated. 147 Phase 1, 110 Phase 2, 23 Not applicable, 15 Phase 3, 9 Early Phase 1.
Follow Medulloblastoma: new trials by email Literature Review of Medulloblastoma trials Research Report on Medulloblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Neurocognitive Outcome in Two Standard Regimen for Treatment of Low-risk Medulloblastoma Bridging Chemotherapy, Induction Cycles A1-A3, Induction Cycles A4-5 - Medulloblastoma | Phase 3 | Not yet recruiting | Nationwide Children's Hospital | 96 | 2027-01-01 | 2026-10-20 |
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-11-30 | 2026-10-30 |
| my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults my.naviGATE Digital Tool - Sarcoma, Osteosarcoma | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 143 | 2026-11-20 | 2026-10-29 |
| Arsenic Trioxide Combined With Chemotherapy for Relapsed SHH-Activated and/or TP53-Mutant Medulloblastoma Arsenic Trioxide (ATO), ETOPOSIDE - Study, Cisplatin - Medulloblastoma | Phase 2 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 78 | 2026-10-01 | 2026-10-02 |
| Pharmacoscopy for Patients With Refractory Primary Brain Tumors Pharmacoscopy 1.0 - Brain (Nervous System) Cancers, Glioblastoma | Phase 2 | Recruiting | University of Zurich | 40 | 2026-09-11 | 2026-09-21 |
| Targeting MYC in High-Risk Medulloblastoma Tumor tissue collection - Medulloblastoma | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 35 | 2026-09-01 | 2026-07-10 |
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| Study of CDK8 Inhibitor RVU120 in Combination With Everolimus in Children With Recurrent or Progressive Group 3 or 4 Medulloblastoma RVU120, Everolimus (Afinitor) tablets - Medulloblastoma Recurrent, Medulloblastoma | Phase 1 | Not yet recruiting | Bożenna Dembowska Bagińska | 48 | 2026-09-01 | 2026-10-08 |
| Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease Liothyronine (L-T3), Bevacizumab, Irinotecan - Medulloblastoma, Medulloblastoma, Childhood | Phase 1 / Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 69 | 2026-08-21 | 2026-09-28 |
| Cognitive Rehabilitation for Survivors of Childhood Medulloblastoma Using Real Time Hemodynamic Neurofeedback rt fMRI Neurofeedback (DLPFC), rt fMRI Neurofeedback (PAC) - Medulloblastoma, Childhood, Survivorship | Not applicable | Recruiting | St. Jude Children's Research Hospital | 40 | 2026-07-26 | 2026-09-23 |
| AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors Pediatric Brain Tumors, Glioma | Not yet recruiting | Huashan Hospital | 1400 | 2026-07-15 | 2026-07-23 | |
| A Study of 177Lu-DTPA-Omburtamab in Children and Adolescents With Brain Cancer or Cancer That Has Spread to the Central Nervous System (CNS) 25 mCi 177Lu- DTPA-omburtamab - Recurrent Medulloblastoma, Refractory Medulloblastoma | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 24 | 2026-07-02 | 2026-10-08 |
| Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors Becotatug Vedotin - Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Nasopharyngeal Carcinoma | Phase 1 | Recruiting | Sun Yat-sen University | 51 | 2026-05-30 | 2026-05-13 |
| Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors Vertebral Body-Sparing Craniospinal Proton Irradiation - Pediatric Central Nervous System Tumors, Medulloblastoma | Not yet recruiting | Ruijin Hospital | 38 | 2026-04-30 | 2026-05-15 | |
| RNA-lipid Particle (RNA-LP) Vaccines for Recurrent/Progressive Medulloblastoma (MB) Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liposome vaccine administered intravenously (RNA loaded lipid particles, RNA-LPs) - Recurrent Medulloblastoma | Phase 1 | Active not recruiting | University of Florida | 24 | 2026-04-24 | 2026-09-29 |
| CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation Medulloblastoma | Recruiting | St. Jude Children's Research Hospital | 184 | 2026-04-20 | 2026-07-06 | |
| Digoxin Medulloblastoma Study Digoxin - Medulloblastoma, Medulloblastoma, Non-WNT/Non-SHH | Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 23 | 2026-01-15 | 2026-08-26 |
| Medulloblastoma Online Video-based Exercise Pilot Study Exercise - Medulloblastoma, Childhood | Not applicable | Recruiting | Aron Onerup | 15 | 2025-12-09 | 2025-12-16 |
| Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study Medulloblastoma Recurrent, Medulloblastoma, Childhood, Recurrent | Recruiting | Mohammad H. Abu Arja | 300 | 2025-09-30 | 2026-09-01 | |
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-07-14 |
Showing 20 of 314. Sign in to see all of them.
Astrocytoma (115) · Central Nervous System Neoplasms (112) · Ependymoma (112) · Glioma (106) · Brain Neoplasms (93) · Oligodendroglioma (88) · Neuroblastoma (84) · Familial ependymoma (74) · Glioblastoma (70) · Choroid Plexus Neoplasms (69) · Neuroectodermal Tumors, Primitive (66) · Rhabdoid Tumor (64) · Optic Nerve Glioma (56) · Pinealoma (51)
Neoplasms by Histologic Type (313) · Neoplasms, Glandular and Epithelial (313) · Neoplasms, Nerve Tissue (313) · Neuroectodermal Tumors (307) · Neoplasms, Neuroepithelial (305) · Neoplasms (296) · Neoplasms, Germ Cell and Embryonal (296) · Neuroectodermal Tumors, Primitive (248) · Neoplasms by Site (224) · Nervous System Diseases (209) · Glioma (208) · Nervous System Neoplasms (207) · Central Nervous System Diseases (170) · Brain Diseases (166) · Central Nervous System Neoplasms (92)
Cyclophosphamide (36) · Temozolomide (33) · Etoposide (26) · Filgrastim (26) · Carboplatin (25) · Cisplatin (23) · Vincristine (22) · Radiotherapy (20) · Magnetic Resonance Spectroscopy (18) · Thiotepa (14) · Irinotecan (13) · Granulocyte Colony-Stimulating Factor (12) · Lomustine (11) · Peripheral Blood Stem Cell Transplantation (11) · Melphalan (9)
National Cancer Institute (NCI) (53) · Children's Oncology Group (18) · Pediatric Brain Tumor Consortium (16) · St. Jude Children's Research Hospital (12) · Giselle Sholler (7) · Novartis Pharmaceuticals (7) · Memorial Sloan Kettering Cancer Center (6) · National Institutes of Health Clinical Center (CC) (6) · City of Hope Medical Center (5) · Duke University (5) · M.D. Anderson Cancer Center (5) · Sue O'Dorisio (5) · Wake Forest University Health Sciences (5) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (5) · Emory University (4)
United States (244) · Canada (42) · Australia (28) · Puerto Rico (24) · France (18) · China (15) · Germany (15) · Italy (15) · Switzerland (15) · United Kingdom (15) · Spain (14) · Netherlands (11) · New Zealand (7) · Denmark (5) · Sweden (5)
Giselle Sholler, MD (6) · Amar Gajjar (4) · Daniel Landi, MD (4) · Darell D. Bigner, MD, PhD (4) · Maryam Fouladi (4) · Maryam Fouladi, MD (4) · Elizabeth Fox, MD (3) · Giles W. Robinson, MD (3) · Kim Kramer, MD (3) · M. Sue O'Dorisio, MD, PhD (3) · Alok Kothari, M.D. (2) · Amar Gajjar, MD (2)
PMID 31401903, PMID 26169613, PMID 32719487, PMID 40073837, PMID 40721826, PMID 40967259, PMID 11410496, PMID 11835236, PMID 15814645, PMID 16234526, PMID 16408203, PMID 16532433, PMID 16533779, PMID 16549835, PMID 16914576, PMID 17019740, PMID 17610262, PMID 17634493, PMID 17941066, PMID 18048828, PMID 18281544, PMID 18281546, PMID 18391430, PMID 18447671, PMID 18470481, PMID 18623206, PMID 18989154, PMID 19065567, PMID 19075272, PMID 19430790, PMID 20044751, PMID 20049936, PMID 20460632, PMID 20847174, PMID 20943374, PMID 21115653, PMID 21850464, PMID 22480131, PMID 23554030, PMID 23956241, PMID 27020837, PMID 27467121, PMID 27914822, PMID 28153957, PMID 29181270, PMID 30118397, PMID 30332335, PMID 30392813, PMID 30730781, PMID 31774710
U10CA180886 (19), U01CA081457 (17), UM1CA081457 (10), U10CA098543 (9), U01CA097452 (8), P30CA033572 (4), R01CA167632 (3), 2023 (2), P30CA008748 (2), P30CA022453 (2), P30CA043703 (2), P30CA086862 (2), U10CA081851 (2), U10CA081920 (2), 2008 (1)