37 completed. 37 Phase 1, 16 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 37 | Completed 37 |
| Phase 2 | 16 | Completed 16 |
Follow Brain Damage, Chronic: new trials by email Literature Review of Brain Damage, Chronic trials Research Report on Brain Damage, Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities Sprint-Intensity Interval Training with Telecoaching - Cerebral Palsy | Phase 1 | Completed | University of Alabama at Birmingham | 42 | 2023-09-29 | 2026-04-02 |
| Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals MTR-601 - Muscle Spasticity, Hypertonia, Muscle | Phase 1 | Completed | Motric Bio | 89 | 2023-09-11 | 2026-06-05 |
| ADX-629 Therapy for Sjogren-Larsson Syndrome ADX-629 - Sjogren-Larsson Syndrome | Phase 1 / Phase 2 | Completed | University of Nebraska | 8 | 2023-01-02 | 2026-05-05 |
| Telehealth Virtual Reality Gaming on Cardiometabolic Health Among Youth With Cerebral Palsy Virtual Reality Exergaming - Cerebral Palsy | Phase 1 | Completed | University of Alabama at Birmingham | 32 | 2022-06-01 | 2026-10-08 |
| A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy UDI-001 - Cerebral Palsy, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 6 | 2021-06-02 | 2025-04-06 |
| Development of a Robotic Ankle Assist Device Robotic Ankle Assist Device (RAAD) - Cerebral Palsy | Phase 1 | Completed | BiOMOTUM, Inc. | 31 | 2020-11-01 | 2025-04-04 |
| A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy HB-adMSCs - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Hope Biosciences LLC | 24 | 2020-01-01 | 2026-01-15 |
| A Study of UCB and MSCs in Children With CP: ACCeNT-CP Infusion of allogeneic umbilical cord blood, Infusion of MSCs - Cerebral Palsy | Phase 1 / Phase 2 | Completed | Joanne Kurtzberg, MD | 91 | 2018-04-10 | 2021-08-19 |
| Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness. Analgesic administration, Placebo administration - Disorders of Consciousness, Severe Brain Injury | Phase 1 | Completed | University of Liege | 19 | 2018-02-21 | 2021-05-03 |
| Cerebrolysin and Neurodevelopment in Preterm Infants Cerebrolysin - Infant Development, Cerebral Palsy | Phase 1 | Completed | Mansoura University Children Hospital | 60 | 2016-06-01 | 2021-03-15 |
| Stem Cells in Umbilical Blood Infusion for CP Matched sibling donor cord blood cell infusion - Cerebral Palsy | Phase 1 | Completed | Murdoch Childrens Research Institute | 12 | 2016-03-01 | 2021-01-20 |
| Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome Intranasal auto-M2-BFs - Organic Brain Syndrome, Nonpsychotic, Neurocognitive Disorders | Phase 1 / Phase 2 | Completed | Russian Academy of Medical Sciences | 30 | 2016-03-01 | 2021-02-18 |
| Assessment of the Safety of Allogeneic Umbilical Cord Blood Infusions in Children With Cerebral Palsy sibling umbilical cord blood - Cerebral Palsy | Phase 1 | Completed | Joanne Kurtzberg, MD | 15 | 2015-11-01 | 2019-12-04 |
| Mechanism of Allogeneic UCB Therapy in Cerebral Palsy allogeneic cord blood transplantation - Cerebral Palsy, Child Development | Phase 1 / Phase 2 | Completed | Bundang CHA Hospital | 90 | 2015-07-29 | 2020-11-04 |
| The Baby CHAMP Study (Children With Hemiparesis Arm and Movement Project) Neurorehabilitation therapy with cast, Neurorehabilitation therapy with splint, Neurorehabilitation bimanual - Hemiparesis, Cerebral Palsy | Phase 1 / Phase 2 | Completed | Virginia Polytechnic Institute and State University | 58 | 2015-01-01 | 2022-03-11 |
| Shockwaves Therapy and Botulinum Toxin for the Treatment of Spasticity in Patients With Cerebral Palsy. A Cross Over RCT shock waves, Botulinum Toxin Type A - Spasticity, Cerebral Palsy | Phase 1 | Completed | Xavi Vidal Novellas | 70 | 2014-09-01 | 2017-03-13 |
| Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects [18F]T807 ([18F]MNI-777) - Alzheimer's Disease (AD), Parkinson's Disease (PD) | Phase 1 | Completed | Molecular NeuroImaging | 16 | 2014-02-01 | 2016-12-16 |
| Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC tDCS, sham tDCS - Vegetative State, Minimally Conscious State | Phase 1 | Completed | University of Liege | 17 | 2014-01-20 | 2019-01-09 |
| Erythropoietin Therapy for Children With Cerebral Palsy: Phase 1 Erythropoietin - Cerebral Palsy | Phase 1 | Completed | MinYoung Kim, M.D. | 11 | 2012-06-01 | 2014-04-08 |
| Therapeutic Riding and Neuromuscular Disease Therapeutic Riding/ Hippotherapy Intervention - Neuromuscular Disease | Phase 1 | Completed | University of Ioannina | 60 | 2012-06-01 | 2018-11-19 |
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Cerebral Palsy (32) · Muscle Spasticity (5) · Brain Injuries (4) · Stroke (4) · Spinal Cord Injuries (3) · Brain Injuries, Traumatic (2) · Chronic Traumatic Encephalopathy (2) · Consciousness Disorders (2) · Muscle Hypertonia (2) · Neuromuscular Diseases (2) · Paresis (2) · Persistent Vegetative State (2) · Alzheimer Disease (1) · Amyotrophic Lateral Sclerosis (1) · Asperger Syndrome (1)
Brain Diseases (37) · Central Nervous System Diseases (37) · Nervous System Diseases (37) · Pathological Conditions, Signs and Symptoms (17) · Neurologic Manifestations (13) · Signs and Symptoms (13) · Wounds and Injuries (11) · Trauma, Nervous System (10) · Craniocerebral Trauma (9) · Mental Disorders (9) · Cardiovascular Diseases (6) · Cerebrovascular Disorders (6) · Musculoskeletal Diseases (6) · Neurobehavioral Manifestations (6)
Stem Cell Transplantation (2) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · ADX-629 (1) · Baclofen (1) · Botulinum Toxins, Type A (1) · Ensure Plus (1) · Equine-Assisted Therapy (1) · Erythropoietin (1) · Exercise (1) · Exergaming (1) · Granulocyte Colony-Stimulating Factor (1) · Hyperbaric Oxygenation (1) · Music Therapy (1) · POLR1G protein, human (1) · Pancrelipase (1)
Joanne Kurtzberg, MD (2) · National Institutes of Health Clinical Center (CC) (2) · Royan Institute (2) · University of Alabama at Birmingham (2) · University of Liege (2) · Acorda Therapeutics (1) · BiOMOTUM, Inc. (1) · Bundang CHA Hospital (1) · Children's Treatment Network (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Hanyang University Seoul Hospital (1) · Holland Bloorview Kids Rehabilitation Hospital (1) · Hope Biosciences LLC (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Mansoura University Children Hospital (1)
United States (19) · Belgium (2) · Canada (2) · Iran (2) · South Korea (2) · Australia (1) · Egypt (1) · Greece (1) · Japan (1) · Russia (1) · Spain (1)
Diane L Damiano, Ph.D. (2) · Hamid Gourabi, PhD (2) · Joanne Kurtzberg, MD (2) · Nasser Aghdami, MD,PhD (2) · Alan Hand, MD (1) · Alexander A Ostanin, MD, PhD (1) · Ali Reza Zali, MD (1) · AliReza Zaali, MD (1) · Antonio Fiaschi, MD PhD (1) · Avraam Ploumis (1) · Byron Lai, PhD (1) · Charles S Cox, MD (1) · Danna Jennings, MD (1) · Dinah Reddihough, MBChB, MD (1) · E. George Wolf, M.D. (1)
PMID 23106988, PMID 24607242, PMID 25593079, PMID 28109298, PMID 28131322, PMID 28867665, PMID 32152173, PMID 35193825, PMID 35811372, PMID 35976192, PMID 37555886, PMID 38087394, PMID 38441939
R03HD107598 (1), R21HD054697 (1), R21HD109358 (1)