10 completed, 4 unknown, 3 recruiting, 2 not yet recruiting. 6 Phase 3, 4 Not applicable, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 6 |
| Not applicable | 4 | Not yet recruiting 2, Completed 1, Unknown 1 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
Follow Bacterial Meningitis: new trials by email Literature Review of Bacterial Meningitis trials Research Report on Bacterial Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Exploring the Combination of Intracalvariosseous and Intravenous Antibiotics for Moderate to Severe Bacterial Meningitis Intracalvariosseous injection vancomycin/tigecycline/polymyxin B, Intravenous injection vancomycin/tigecycline/polymyxin B, Conventional treatment - Blood-Brain Barrier, Bacterial Meningitis | Not applicable | Not yet recruiting | yilong Wang | 9 | 2026-09-21 | 2026-09-17 |
| Intracalvariosseous Plus Intravenous Antibiotics for Moderate-to-Severe Bacterial Meningitis Intracalvariosseous injection vancomycin/tigecycline/polymyxin B, Intravenous injection vancomycin/tigecycline/polymyxin B, Conventional treatment - Blood-Brain Barrier, Bacterial Meningitis | Not applicable | Not yet recruiting | yilong Wang | 86 | 2026-04-01 | 2026-03-27 |
| Acute Treatment and Long-term Assessment of Adult Infectious Meningitis Viral Meningitis, Bacterial Meningitis | Recruiting | Hospital Israelita Albert Einstein | 624 | 2026-03-30 | 2026-08-13 | |
| Augmented Renal Clearance in Neurocritical Care TBI (Traumatic Brain Injury), Status Epilepticus | Recruiting | University of Alberta | 512 | 2021-10-01 | 2026-02-18 | |
| Early Diagnosis of Native and Device-associated Meningitis D-lactate test, Standard diagnostic tests - Bacterial Meningitis, Fungal Meningitis | Not applicable | Unknown | Charite University, Berlin, Germany | 842 | 2021-06-01 | 2021-12-07 |
| Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid - Bacterial Meningitis, Augmented Renal Clearance | Unknown | Shandong University | 300 | 2020-10-01 | 2021-04-13 | |
| Confirmatory Study of BK1310 in Healthy Infants DPT-IPV-Hib, Hib vaccine, DPT-IPV - Tetanus, Diphtheria | Phase 3 | Completed | Tanabe Pharma Corporation | 267 | 2019-04-01 | 2026-01-06 |
| Neonatal Bacterial Meningitis Cohort neonatal bacterial meningitis risk score - Bacterial Meningitis, Neonatal Infection | Unknown | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 10000 | 2017-12-01 | 2018-04-17 | |
| Meningitis With Cerebral Vasculitis in Children Bacterial Meningitis | Completed | University Hospital, Montpellier | 17 | 2017-06-01 | 2018-07-26 | |
| Driving Reduced AIDS-associated Meningo-encephalitis Mortality DREAMM - AIDS-Related Opportunistic Infections, Meningo-encephalitis | Not applicable | Completed | St George's, University of London | 495 | 2016-04-23 | 2022-05-04 |
| Vitamin d Levels in Children With Bacterial Meningitis Bacterial Meningitis | Unknown | Gang Liu | 50 | 2015-05-01 | 2015-06-10 | |
| Central Nervous System Infections in Denmark Community-acquired CNS infections - Central Nervous System Infections, Bacterial Meningitis | Recruiting | Aalborg University Hospital | 1900 | 2015-01-01 | 2024-05-16 | |
| DTaP-IPV/Hib Vaccine Primary & Booster Vaccinations Versus Co-administration of DTaP-IPV and Hib Vaccine in Japanese Infants DTaP-IPV/Hib Combined vaccine, DTaP-IPV vaccine and Hib vaccine - Tetanus, Diphtheria | Phase 3 | Completed | Sanofi Pasteur, a Sanofi Company | 424 | 2014-10-01 | 2022-04-25 |
| Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics) - Neurological Disorders, Cerebral Malaria | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 352 | 2012-09-01 | 2016-01-18 |
| Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 75 Years of Age in India Meningococcal ACWY conjugate vaccine - Bacterial Meningitis | Phase 3 | Completed | Novartis | 180 | 2012-03-01 | 2018-10-09 |
| Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Infusion with paracetamol, Bolus without paracetamol - Bacterial Meningitis | Phase 4 | Completed | University of Helsinki | 375 | 2012-02-01 | 2019-09-24 |
| Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care: - Adenovirus, Anesthesia | Completed | Daniel Benjamin | 3520 | 2011-11-01 | 2023-09-06 | |
| Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 18 Years in Taiwan Meningococcal ACWY conjugate vaccine - Bacterial Meningitis | Phase 3 | Completed | Novartis | 341 | 2011-08-01 | 2014-09-22 |
| IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Mild induced hypothermia (32-34°C), local recommendations and guidelines - Bacterial Meningitis | Phase 4 | Terminated | Assistance Publique - Hôpitaux de Paris | 98 | 2009-03-01 | 2012-09-17 |
| Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Glycerol and paracetamol, Paracetamol, Placebo - Bacterial Meningitis | Phase 3 | Completed | Kamuzu University of Health Sciences | 466 | 2008-03-01 | 2012-07-10 |
Meningitis, Bacterial (20) · Meningitis (4) · Central Nervous System Infections (2) · Diphtheria (2) · Meningitis, Cryptococcal (2) · Meningitis, Fungal (2) · Meningitis, Viral (2) · Neurosyphilis (2) · Poliomyelitis (2) · Seizures (2) · Tetanus (2) · Whooping Cough (2) · AIDS-Related Complex (1) · AIDS-Related Opportunistic Infections (1) · Adenoviridae Infections (1)
Bacterial Infections (20) · Bacterial Infections and Mycoses (20) · Central Nervous System Bacterial Infections (20) · Central Nervous System Diseases (20) · Neuroinflammatory Diseases (20) · Infections (19) · Nervous System Diseases (19) · Central Nervous System Infections (18) · Meningitis (16) · Virus Diseases (7) · Brain Diseases (5) · Gram-Positive Bacterial Infections (5) · RNA Virus Infections (5) · Actinomycetales Infections (4) · Central Nervous System Fungal Infections (4)
Acetaminophen (2) · HibTITER protein, Haemophilus influenzae (2) · Alfentanil (1) · Amikacin (1) · Aminocaproic Acid (1) · Bosentan (1) · Cefepime (1) · Cidofovir (1) · Ciprofloxacin (1) · Clozapine (1) · Fosfomycin (1) · Glycerol (1) · Guidelines as Topic (1) · Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate (1) · Haloperidol (1)
Novartis (2) · yilong Wang (2) · Aalborg University Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Charite University, Berlin, Germany (1) · Daniel Benjamin (1) · Gang Liu (1) · Hospital Israelita Albert Einstein (1) · Institute of Tropical Medicine, Belgium (1) · Kamuzu University of Health Sciences (1) · Sanofi Pasteur, a Sanofi Company (1) · Shandong University (1) · St George's, University of London (1) · Tanabe Pharma Corporation (1) · University Hospital, Montpellier (1)
China (5) · Canada (2) · France (2) · Japan (2) · Malawi (2) · United States (2) · Angola (1) · Brazil (1) · Cameroon (1) · Democratic Republic of the Congo (1) · Denmark (1) · Germany (1) · India (1) · Israel (1) · Singapore (1)
Andrej Trampuz, PD Dr. med (1) · Angela Loyse, MD (1) · Anna M Gomes, MD (1) · Chi Hornik, PharmD (1) · Dr. A Amaresh (1) · Dr. Nitya Gogtay (1) · Dr. Sanjay Lalwani (1) · Dr. Sharad Agarkhedkar (1) · Elizabeth M Molyneux, FRCPCH (1) · Emmanuel Bottieau, MD (1) · Heikki O Peltola, MD, PhD (1) · Henrik Nielsen, Professor (1) · Henrique A Fonseca, PhD (1)
PMID 24105303, PMID 24614374, PMID 24949994, PMID 25075804, PMID 26039810, PMID 26926644, PMID 27522443, PMID 28137820, PMID 28290120, PMID 28779462, PMID 29084742, PMID 29271816, PMID 29435949, PMID 29677389, PMID 30790601, PMID 31317556, PMID 31548185, PMID 31814149, PMID 32246138, PMID 32307307, PMID 32324313, PMID 32497307, PMID 33029806, PMID 33903114, PMID 34302290, PMID 35288394, PMID 35370711, PMID 35491971, PMID 37802567, PMID 38582691, PMID 41247430