6 completed, 4 not yet recruiting, 2 active not recruiting, 2 withdrawn. 17 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 17 | Completed 6, Not yet recruiting 4, Active not recruiting 2, Withdrawn 2, Enrolling by invitation 1, Recruiting 1, Unknown 1 |
Follow Atrophy: new trials by email Literature Review of Atrophy trials Research Report on Atrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES) - Critical Illness, Sarcopenia | Early Phase 1 | Not yet recruiting | University of Maryland, Baltimore | 78 | 2027-03-01 | 2026-05-06 |
| Metformin and ACLR Muscle Recovery Metformin, Placebo - Atrophy, Inflammation | Early Phase 1 | Not yet recruiting | University of Utah | 40 | 2026-11-01 | 2026-07-13 |
| Sarcopenia in Chronic Kidney Disease (CKD) Patients Valine, EEA - Chronic Kidney Disease, Sarcopenia | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 20 | 2026-08-24 | 2026-08-11 |
| Clinical Safety Evaluation and Preliminary Efficacy Study of Subcutaneous Myografts Transplantation Autologous differentiated myocyte transplantation - Metabolic Disease, Amyotrophy | Early Phase 1 | Not yet recruiting | National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, China | 6 | 2026-07-01 | 2026-02-23 |
| Intertrochanteric Femur Fracture Patients Who Receive Metformin With a Placebo Placebo, Metformin - Intertrochanteric Femur Fracture, Muscle Atrophy | Early Phase 1 | Enrolling by invitation | University of Utah | 60 | 2025-09-04 | 2026-04-29 |
| Metformin and Muscle Recovery Metformin, Placebo - Muscle Atrophy or Weakness | Early Phase 1 | Recruiting | University of Utah | 50 | 2024-09-01 | 2025-12-05 |
| Impact of Orally Administered BPM31510 on Mitochondrial Energetics in Older Adults With Sarcopenia BPM31510, Placebo - Sarcopenia | Early Phase 1 | Withdrawn | AdventHealth Translational Research Institute | 2023-12-01 | 2023-07-24 | |
| Ankle Assistance and Resistance in Older Adults Ankle resistance and biofeedback - Sarcopenia | Early Phase 1 | Completed | Northern Arizona University | 9 | 2023-02-01 | 2025-10-01 |
| Bacterial Intestinal Gut Modification Around Cancer Surgery (BIG MACS) Diet Standard Diet, BIG MACS Diet - Dysbiosis, Sarcopenia | Early Phase 1 | Completed | University of Minnesota | 14 | 2023-01-03 | 2025-05-13 |
| Body Composition Changes After TIPS and Associated Clinical Outcomes Transjugular Intrahepatic Portosystemic Shunt (TIPS) creation - Cirrhosis, Liver, Sarcopenia | Early Phase 1 | Unknown | Oregon Health and Science University | 22 | 2022-05-01 | 2023-11-07 |
| Ruxolitinib for Cancer Cachexia Identify any dose-limiting toxicity (DLT) when ruxolitinib is administered to NSCLC cachexia patients. - Stage IV Non-small Cell Lung Cancer, Cachexia | Early Phase 1 | Active not recruiting | Tu Dan | 10 | 2022-02-23 | 2026-07-07 |
| Role of Metformin on Muscle Health of Older Adults Metformin (Bed Rest), Placebo (Bed Rest), Metformin (2 week run-in only) - Muscle Atrophy, Insulin Resistance | Early Phase 1 | Active not recruiting | University of Utah | 64 | 2019-08-01 | 2025-12-05 |
| Omega-3 Supplementation After Surgical Treatment of Obesity Omega-3, Mineral Oil - Obesity | Early Phase 1 | Completed | Instituto de Cardiologia do Rio Grande do Sul | 150 | 2019-04-10 | 2024-07-10 |
| Efficacy of Saline Injection Therapy in Atrophic Acne Scars saline injection therapy in post-acne atrophic scars - Atrophic, Scars | Early Phase 1 | Completed | Jinnah Postgraduate Medical Centre | 49 | 2019-01-01 | 2020-01-28 |
| The Effects of 17β-estradiol on Skeletal Muscle 17β-estradiol, Polycose - Muscle Atrophy | Early Phase 1 | Withdrawn | McMaster University | 2017-05-01 | 2018-08-16 | |
| Clinical Trial to Assess the Preventive Effects of Cetylpyridinium Chloride on Sarcopenia Cetylpyridinium Chloride (CPC), placebo - Sarcopenia | Early Phase 1 | Completed | Seoul National University Hospital | 100 | 2015-10-01 | 2021-10-08 |
| Preventive Effects of Cetylpyridinium Chloride on SarcopeniaStudy cetylpyridinium chloride, Placebo - Sarcopenia | Early Phase 1 | Completed | Seoul National University Hospital | 65 | 2014-11-13 | 2021-03-29 |
Sarcopenia (9) · Muscular Atrophy (6) · Acne Vulgaris (1) · Anorexia (1) · Asthenia (1) · Cachexia (1) · Carcinoma, Non-Small-Cell Lung (1) · Cicatrix (1) · Colonic Neoplasms (1) · Critical Illness (1) · Dysbiosis (1) · Fibrosis (1) · Frailty (1) · Inflammation (1)
Pathological Conditions, Anatomical (17) · Pathological Conditions, Signs and Symptoms (17) · Nervous System Diseases (16) · Neurologic Manifestations (16) · Neuromuscular Manifestations (16) · Signs and Symptoms (16) · Muscular Atrophy (9) · Pathologic Processes (6) · Nutritional and Metabolic Diseases (3) · Body Weight (2) · Digestive System Diseases (2) · Disease Attributes (2) · Neoplasms (2) · Neoplasms by Site (2)
Metformin (4) · Cetylpyridinium (2) · Bed Rest (1) · Biofeedback, Psychology (1) · Docosahexaenoic Acids (1) · Estradiol (1) · Facility Design and Construction (1) · Glucans (1) · Mineral Oil (1) · Portasystemic Shunt, Transjugular Intrahepatic (1) · Saline Solution (1) · Sodium Chloride (1) · Valine (1)
University of Utah (4) · Seoul National University Hospital (2) · AdventHealth Translational Research Institute (1) · Instituto de Cardiologia do Rio Grande do Sul (1) · Jinnah Postgraduate Medical Centre (1) · McMaster University (1) · National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, China (1) · Northern Arizona University (1) · Oregon Health and Science University (1) · The University of Texas Health Science Center at San Antonio (1) · Tu Dan (1) · University of Maryland, Baltimore (1) · University of Minnesota (1)
United States (11) · Brazil (1) · Canada (1) · China (1) · Pakistan (1) · South Korea (1)
Micah Drummond (3) · Cyrus Jahansouz (1) · Justin Haller, M.D. (1) · Paul Coen, PhD (1) · Pengbin YIn (1) · Rabia Ghafoor, FCPS (1) · Stuart Phillips, PhD (1) · Subrata Debnath, PhD (1) · Sun Gun Chung, MD, PhD (1) · Tu Dan, MD (1)
PMID 24737557, PMID 25588037, PMID 27688440, PMID 32150289, PMID 32829751, PMID 35405248, PMID 36594428, PMID 36947713, PMID 37486024, PMID 38263952, PMID 39084052, PMID 40381110, PMID 41805969, PMID 42289186, PMID 6588248, PMID 6727655, PMID 707331, PMID 7151348, PMID 8007590, PMID 8154485
P30AG044271 (1)