7 completed, 2 unknown, 2 withdrawn, 1 not yet recruiting. 7 Not applicable, 2 Early Phase 1, 2 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 4, Unknown 2, Withdrawn 1 |
| Early Phase 1 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 1, Withdrawn 1 |
| Phase 1 | 1 | Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow Valine: new trials by email Literature Review of Valine trials Research Report on Valine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients Metformin, Val, Cel and Met XR Low, Val, Cel and Met XR High - Type 2 Diabetes, High Blood Pressure | Phase 1 / Phase 2 | Withdrawn | ARKAY Therapeutics | 2026-12-10 | 2026-07-16 | |
| Sarcopenia in Chronic Kidney Disease (CKD) Patients Valine, EEA - Chronic Kidney Disease, Sarcopenia | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 20 | 2026-08-24 | 2026-08-11 |
| Oral Intradialytic Amino Acid Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis Valine, EEA - End Stage Renal Disease | Early Phase 1 | Completed | The University of Texas Health Science Center at San Antonio | 28 | 2024-10-18 | 2026-08-26 |
| Liquid Valine and Isoleucine in Maple Syrup Urine Disease Valine oral solution (50mg/ml) and isoleucine oral solution (25mg/ml) - Maple Syrup Urine Disease | Not applicable | Unknown | Meta Healthcare Ltd | 5 | 2024-10-01 | 2024-09-03 |
| Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity Cellulose (control), Glycine, Alanine - Atherosclerosis, Diet Modification | Not applicable | Unknown | Rambam Health Care Campus | 110 | 2017-07-01 | 2017-06-08 |
| Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults Essential Amino Acids (EAA), Placebo (Alanine) - Muscle Atrophy, Quality of Life | Phase 2 | Completed | University of Oregon | 80 | 2014-12-01 | 2024-07-23 |
| Dietary Intake and Circulating Levels of Branched Chain Amino Acids Diet high in amino acid levels, Diet low in amino acid levels - Dietary Intake of Branched Chain Amino Acids | Not applicable | Completed | Massachusetts General Hospital | 5 | 2014-04-01 | 2016-10-07 |
| Amino Acid Supplementation in Recovery From Traumatic Brain Injury Amino Acids, Placebo of inert compounds, Valine - Traumatic Brain Injury | Not applicable | Withdrawn | The University of Texas Medical Branch, Galveston | 2011-11-01 | 2015-02-11 | |
| The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients Branched Chained Amino Acids, Cellulose Placebo mix - Type 2 Diabetes, Healthy Individuals | Not applicable | Completed | Loma Linda University | 50 | 2010-10-01 | 2011-04-22 |
| Estrogen and Serotonin on Changing Brain Chemistry estrogen patch, Amino acids, Placebo Patch - Menopause | Not applicable | Completed | University of Colorado, Denver | 47 | 2010-03-04 | 2021-04-02 |
| Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation Essential amino acids, Alanine - Osteoarthritis | Not applicable | Completed | University of Oregon | 60 | 2008-06-01 | 2014-12-04 |
| Long Term Study of Valsartan and Amlodipine in Patients With Essential Hypertension (Extension to Study CVAA489A1301) Valsartan + Amlodipine besilate - Hypertension | Phase 3 | Completed | Novartis | 403 | 2007-02-01 | 2017-03-28 |
Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Hypertension (2) · Arthritis (1) · Atherosclerosis (1) · Brain Injuries, Traumatic (1) · Disease (1) · Fatigue (1) · Kidney Failure, Chronic (1) · Maple Syrup Urine Disease (1) · Memory Disorders (1) · Muscular Atrophy (1) · Obesity (1) · Osteoarthritis (1) · Renal Insufficiency, Chronic (1)
The University of Texas Health Science Center at San Antonio (2) · University of Oregon (2) · ARKAY Therapeutics (1) · Loma Linda University (1) · Massachusetts General Hospital (1) · Meta Healthcare Ltd (1) · Novartis (1) · Rambam Health Care Campus (1) · The University of Texas Medical Branch, Galveston (1) · University of Colorado, Denver (1)
United States (9) · Japan (1)
Subrata Debnath, PhD (2) · Anita MacDonald (1) · Cynthia Neill Epperson, M.D. (1) · Geoffrey Walford, M.D. (1) · Hans C Dreyer, PT, PhD (1) · Jerrold Petrofsky, Doctoral PhD (1) · Melinda Sheffield-Moore, Ph.D. (1) · Ravi Kumar, Ph.D. (1) · Tony Hayek, Prof (1)
PMID 12449285, PMID 17364057, PMID 22204954, PMID 24135139, PMID 24401239, PMID 24737557, PMID 26733251, PMID 26781817, PMID 26829246, PMID 30280129, PMID 31343947, PMID 32150289, PMID 32829751, PMID 36594428, PMID 38263952, PMID 39084052, PMID 40381110, PMID 6588248, PMID 6727655, PMID 707331, PMID 7151348, PMID 8007590, PMID 8154485
K01HD057332 (1), KL2TR002646 (1), P30AG044271 (1), P50MH099910 (1), R01AG046401 (1)